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01-05-2016 | Original Article

Fibrin-related markers for diagnosing acute-, subclinical-, and pre-venous thromboembolism in patients with major orthopedic surgery

Authors: Toshio Yamaguchi, Hideo Wada, Shinichi Miyazaki, Masahiro Hasegawa, Hiroki Wakabayashi, Kunihiro Asanuma, Naoki Fujimoto, Takeshi Matsumoto, Kohshi Ohishi, Akane Sakaguchi, Norikazu Yamada, Masaaki Ito, Yoshiki Yamashita, Naoyuki Katayama, Akihiro Sudo

Published in: International Journal of Hematology | Issue 5/2016

Abstract

Venous thromboembolism (VTE) is a common complication in patients who have undergone major orthopedic surgery, but there are few predictors of VTE after major orthopedic surgery treated with an anticoagulant. We measured levels of fibrin-related markers (FRMs), such as d-dimer, soluble fibrin (SF), and fibrinogen and fibrin degradation products (FDPs) in 66 patients with acute-phase VTE, and 367 patients undergoing major orthopedic surgery. Plasma FDP, d-dimer, and SF levels were significantly higher in patients with acute VTE, but only FDP and d-dimer levels were significantly higher in subclinical VTE. Adequate cut-off levels of d-dimer were 2.2 μg/ml for diagnosing acute VTE and 1.5 μg/ml for diagnosing subclinical VTE. d-dimer of less than 1.9 or 0.7 μg/ml ruled out acute VTE or subclinical VTE. d-dimer of more than 1.3 μg/ml preoperatively showed a moderate risk for postoperative VTE. Measurement of FRMs is useful for evaluating the risk of subclinical or postoperative VTE in patients with major orthopedic surgery. In particular, FDP is the most valuable marker for diagnosing acute VTE, whereas d-dimer is the most valuable for diagnosing subclinical VTE or predicting VTE.

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Title: Fibrin-related markers for diagnosing acute-, subclinical-, and pre-venous thromboembolism in patients with major orthopedic surgery
Authors: Toshio Yamaguchi
Hideo Wada
Shinichi Miyazaki
Masahiro Hasegawa
Hiroki Wakabayashi
Kunihiro Asanuma
Naoki Fujimoto
Takeshi Matsumoto
Kohshi Ohishi
Akane Sakaguchi
Norikazu Yamada
Masaaki Ito
Yoshiki Yamashita
Naoyuki Katayama
Akihiro Sudo
Publication date: 01-05-2016
Publisher: Springer Japan
Published in: International Journal of Hematology / Issue 5/2016
Print ISSN: 0925-5710
Electronic ISSN: 1865-3774
DOI: https://doi.org/10.1007/s12185-016-1954-x

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