Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Irish Journal of Medical Science (1971 -)
Published in: Irish Journal of Medical Science (1971 -) 3/2011

01-09-2011 | Original Article

Fetomaternal transfusion after amniocentesis and cordocentesis

Authors: J. Sikovanyecz, E. Horváth, N. Pásztor, A. Keresztúri, J. Szabó, A. Pál

Published in: Irish Journal of Medical Science (1971 -) | Issue 3/2011

Login to get access

Abstract

Objective

To compare the extent of fetomaternal transfusion after amniocentesis and cordocentesis.

Setting

Three-hundred and forty-five amniocentesis and 268 cordocentesis were performed for genetic indications. The extent of fetomaternal transfusion was calculated on the basis of the maternal serum alpha-fetoprotein level changes.

Results

The mean fetomaternal transfusion was 6.3 and 62 μL in the amniocentesis and cordocentesis groups, respectively. Transplacental needle passage and longer procedural time were risk factors for fetomaternal transfusion. The frequency of transplacental passage was higher and the procedural time was longer in the cordocentesis group. The fetal loss rate was 1.17% after amniocentesis and 1.2% after cordocentesis, respectively.

Conclusions

Cordocentesis causes more injury to the extrafetal compartment, which results in a higher level of fetomaternal transfusion. However, though a nearly ten times higher fetomaternal transfusion was observed after cordocentesis, there was no essential difference in pregnancy outcome between the two groups.
Literature
1.
Blackwell SC, Abundis MG, Nehra PC (2002) Five-year experience with midtrimester amniocentesis performed by a single group of obstetricians-gynecologists at a community hospital. Am J Obstet Gynecol 186:1130–1132PubMedCrossRef
2.
Papantoniou NE, Daskalakis GJ, Tziotis JG, Kitmirides SJ, Mesogitis SA, Antsaklis AJ (2001) Risk factors predisposing to fetal loss following a second trimester amniocentesis. Br J Obstet Gynaecol 108:1053–1056CrossRef
3.
Horger EO 3rd, Finch H, Vincent VA (2001) A single physician’s experience with four thousand six hundred genetic amniocenteses. Am J Obstet Gynecol 185(2):279–288PubMedCrossRef
4.
Tongson T, Wanapirak C, Sirivatanapa P, Piyamongkol W, Sirichotiyakul S, Yampochai A (1998) Amniocentesis-related fetal loss: a cohort study. Obstet Gynecol 92:64–67CrossRef
5.
Sikovanyecz J, Horváth E, Sallay É, Gellén J, Pál A, Szabó J (2001) Fetomaternal transfusion and pregnancy outcome after cordocentesis. Fetal Diagn Ther 16:83–89PubMedCrossRef
6.
Weiner CP, Okamura K (1996) Diagnostic fetal blood sampling-technique related losses. Fetal Diagn Ther 11(3):169–175PubMedCrossRef
7.
Petrikovsky B, Schneider EP, Klein VR, Wyse LJ (1997) Cordocentesis using the combined technique; needle guide-assisted and free-hand. Fetal Diagn Ther 12(4):252–254PubMedCrossRef
8.
Tongsong T, Wanapirak C, Kunavikatikul C, Sirirchotiyakul S, Piyamongkol W, Chanprapaph P (2001) Fetal loss rate associated with cordocentesis at midgestation. Am J Obstet Gynecol 184(4):719–723PubMedCrossRef
9.
Tongsong T, Wanapirak C, Kunavikatikul C, Sirirchotiyakul S, Piyamongkol W, Chanprapaph P (2000) Cordocentesis at 16–24 weeks of gestation: experience of 1320 cases. Prenat Diagn 20(3):224–228PubMedCrossRef
10.
Bernaschek G, Yildiz A, Kolonkaya A, Stuempflen I, Deutinger J (1995) Complications of cordocentesis in high-risk pregnancies: effect on fetal loss or preterm delivery. Prenat Diagn 15:995–1000PubMedCrossRef
11.
Tabor A, Bang J, Nørgaard-Pedersen B (1987) Feto-maternal haemorrhage associated with genetic amniocentesis: results of a randomized trial. Br J Obstet Gynaecol 94:528–534PubMedCrossRef
12.
Buscaglia M, Ghisoini L, Levi-Setti PE (1996) Alpha-fetoprotein elevation in maternal serum after percutaneous umbilical blood sampling (PUBS). Prenat Diagn 16:375–376PubMedCrossRef
13.
Van Selm M, Kanhai HHH, Van Loon AJ (1995) Detection of fetomaternal haemorrhage associated with cordocentesis using serum α-fetoprotein and the Kleihauer technique. Prenat Diagn 15:313–316PubMedCrossRef
14.
Kohlenberg CF, Ellwood DA (1994) Fetomaternal haemorrhage treated with intravascular transfusion: a late complication of amniocentesis? Br J Obstet Gynaecol 101:912–913PubMedCrossRef
15.
Dierker LJ (1985) Elevated maternal α-fetoprotein levels with subsequent fetal exsanguination. Am J Obstet Gynecol 152:82–83PubMed
16.
Blakemore KJ, Baumgarten A, Schoenfeld-Dimaio M, Hobbis JC, Mason EA, Mahoney MJ (1986) Rise in maternal serum α-fetoprotein concentration after chorionic villus sampling and the possibility of immunization. Am J Obstet Gynecol 155:988–993PubMed
17.
Gellén J, Kovács Z, Szontágh FE, Boda D (1965) Surgical termination of pregnancy as a cause of rhesus sensitization. Br Med J 2:1471–1472PubMedCrossRef
18.
Zipursky A, Israels LG (1967) The pathogenesis and prevention of Rh immunization. Can Med Assoc J 97:1245–1257PubMed
19.
Lele AS, Carmody PJ, Hurd ME, O’Leary JA (1982) Fetomaternal bleeding following diagnostic amniocentesis. Obstet Gynecol 60:60–64PubMed
20.
Holzgreve W, Miny P, Basaran S, Fuhrmann W, Beller FK (1987) Safety of placental biopsy in the second and third trimesters. N Engl J Med 37:1159
21.
Macdonald DJ, Kelly AM (1978) The rapid quantitation of serum alpha-fetoprotein by two-site microenzyme immunoassay. Clin Chim Acta 87:367–372PubMedCrossRef
22.
Nicolaides KH, Cicero S, Liao AW (2000) One-stop clinic for assessment of risk of chromosomal defects at 12 weeks of gestation. Prenat Neonat Med 5:145–154
23.
Kolibianakis E, Osmanagaoglu K, De Catte L et al (2003) Prenatal genetic testing by amniocentesis appears to result in lower risk of fetal loss than chorionic villus sampling in singleton pregnancies achieved by intracytoplasmic sperm injection. Fertil Steril 79:374–378PubMedCrossRef
24.
Muller F, Thibaud D, Poloce F et al (2002) Risk of amniocentesis in women screened positive for Down syndrome with second trimester maternal serum markers. Prenat Diagn 22:1036–1039PubMedCrossRef
25.
Boyd PA (1992) Why might maternal serum AFP be higher in pregnancies in which the fetus is normally formed? Br J Obstet Gynaecol 99:93–95PubMedCrossRef
26.
Papp Z (1990) Obstetric genetics. Akadémiai Kiadó, Budapest, pp 181–189
27.
Hytten F (1985) Blood volume changes in normal pregnancy. Clin Haematol 14:426–428
28.
Gruslin-Giroux A, Shields LE, Widness JA, Brace RA (1997) Fetal plasma iron and restoration of red blood cell mass after hemorrhage of the ovine fetus. Am J Obstet Gynecol 177:1172–1177PubMedCrossRef
Metadata
Title
Fetomaternal transfusion after amniocentesis and cordocentesis
Authors
J. Sikovanyecz
E. Horváth
N. Pásztor
A. Keresztúri
J. Szabó
A. Pál
Publication date
01-09-2011
Publisher
Springer-Verlag
Published in
Irish Journal of Medical Science (1971 -) / Issue 3/2011
Print ISSN: 0021-1265
Electronic ISSN: 1863-4362
DOI
https://doi.org/10.1007/s11845-010-0663-3

Other articles of this Issue 3/2011

Irish Journal of Medical Science (1971 -) 3/2011 Go to the issue

Brief Report

Skin puckering an uncommon sign of underlying humeral neck fracture: a case report

Original Article

An anaesthetic pre-operative assessment clinic reduces pre-operative inpatient stay in patients requiring major vascular surgery

Original Article

Hesperidin promotes cyclobutane pyrimidine dimer repair in UVB-exposed mice epidermis

Case Report

Unusual presentation of gastrointestinal stromal tumor with early cerebral involvement

Original Article

Preoperative tests: an Irish perspective

Original Article

Coronary angiography in noncompaction with and without neuromuscular disorders
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine
Image Credits