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01-10-2014 | Case study

FET-PET-based reirradiation and chloroquine in patients with recurrent glioblastoma

First tolerability and feasibility results

Authors: Angelika Bilger, Martin-Immanuel Bittner, Anca-L. Grosu, Nicole Wiedenmann, Philipp T. Meyer, Elke Firat, Gabriele Niedermann, Wolfgang A. Weber, Dr. Dušan Milanović

Published in: Strahlentherapie und Onkologie | Issue 10/2014

Abstract

Background

Treatment of recurrent glioblastoma (rGBM) remains an unsolved clinical problem. Reirradiation (re-RT) can be used to treat some patients with rGBM, but as a monotherapy it has only limited efficacy. Chloroquine (CQ) is an anti-malaria and immunomodulatory drug that may inhibit autophagy and increase the radiosensitivity of GBM.

Patients and methods

Between January 2012 and August 2013, we treated five patients with histologically confirmed rGBM with re-RT and 250 mg CQ daily.

Results

Treatment was very well tolerated; no CQ-related toxicity was observed. At the first follow-up 2 months after finishing re-RT, two patients achieved partial response (PR), one patient stable disease (SD), and one patient progressive disease (PD). One patient with reirradiated surgical cavity did not show any sign of PD.

Conclusion

In this case series, we observed encouraging responses to CQ and re-RT. We plan to conduct a CQ dose escalation study combined with re-RT.

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Title: FET-PET-based reirradiation and chloroquine in patients with recurrent glioblastoma
First tolerability and feasibility results
Authors: Angelika Bilger
Martin-Immanuel Bittner
Anca-L. Grosu
Nicole Wiedenmann
Philipp T. Meyer
Elke Firat
Gabriele Niedermann
Wolfgang A. Weber
Dr. Dušan Milanović
Publication date: 01-10-2014
Publisher: Springer Berlin Heidelberg
Published in: Strahlentherapie und Onkologie / Issue 10/2014
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-014-0693-2

At a glance: The STEP trials

Springer Medicine

FET-PET-based reirradiation and chloroquine in patients with recurrent glioblastoma

First tolerability and feasibility results

Abstract

Background

Patients and methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Patients and methods

Results

Conclusion

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