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Journal of Assisted Reproduction and Genetics

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01-04-2020 | Fertility | Fertility Preservation

Oncologic oocyte cryopreservation: national comparison of fertility preservation between women with and without cancer

Authors: Jennifer F. Kawwass, Lisa M. Shandley, Sheree L. Boulet, Heather S. Hipp

Published in: Journal of Assisted Reproduction and Genetics | Issue 4/2020

Abstract

Purpose

The majority of data regarding oocyte cryopreservation (OC) outcomes focuses on healthy women. We compare trends, cycle characteristics, and outcomes between women freezing oocytes for fertility preservation due to cancer versus elective and other medical or fertility-related diagnoses.

Methods

Retrospective cohort using national surveillance data includes all autologous OC cycles between 2012 and 2016. Cycles were divided into 4 distinct groups: cancer, elective, infertility, and medically indicated. We calculated trends and compared cycle and outcome characteristics between the 4 groups. We used multivariable log-binomial models to estimate associations between indication and gonadotropin dose, hyperstimulation, and cancelation and used Poisson regression models to estimate associations between indication and oocyte yield and maturity.

Results

The study included 29,631 autologous OC cycles. Annual total (2925 to 8828) and cancer-related (177 to 504) cycles increased over the study period; the proportions remained constant. Compared to elective, cancer-related cycles were more likely to be performed among women < 35 years old, with higher BMI, living in the South, using an antagonist protocol. Compared to elective OC cycles, gonadotropin dose (aRR 0.89, 95%CI 0.80–0.99), cancelation (aRR 0.90, 95%CI 0.70–1.14), and hyperstimulation (aRR 1.46, 95%CI 0.77–2.29) were not different for cancer-related cycles. Oocyte yield and percent maturity were comparable in both groups.

Conclusion

The number of OC cycles among women with cancer has increased; however, the percentage OC cycles for cancer have remained stable. While patient demographic characteristics were different among those undergoing OC for cancer indication, cycle outcomes were comparable to elective OC. The outcomes of the subsequent oocyte thaw, fertilization, and embryo transfer cycles remain unknown.

Available only for authorised users

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Title: Oncologic oocyte cryopreservation: national comparison of fertility preservation between women with and without cancer
Authors: Jennifer F. Kawwass
Lisa M. Shandley
Sheree L. Boulet
Heather S. Hipp
Publication date: 01-04-2020
Publisher: Springer US
Keywords: Fertility
Infertility
Infertility
Published in: Journal of Assisted Reproduction and Genetics / Issue 4/2020
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-020-01715-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Oncologic oocyte cryopreservation: national comparison of fertility preservation between women with and without cancer

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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