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Open Access 01-12-2021 | Fertility | Case report

Severe hemoperitoneum resulting from restart of letrozole after oocyte retrieval procedure: a case report

Authors: Haipeng Huang, Yasushi Takai, Kouki Samejima, Yosuke Gomi, Tatsuya Narita, Shunichiro Ichinose, Yukiko Itaya, Yosihisa Ono, Sigetaka Matsunaga, Masahiro Saitoh, Hiroyuki Seki

Published in: Journal of Medical Case Reports | Issue 1/2021

Abstract

Background

In the field of oncofertility, patients with breast cancer are often administered letrozole as an adjuvant drug before and after oocyte retrieval to prevent an increase in circulating estradiol.

Case presentation

We report a case of abdominal hemorrhage due to an ovarian rupture in a 29-year-old Japanese patient who restarted letrozole 2 days after an oocyte retrieval procedure in which 14 mature oocytes were retrieved. The patient had sought embryo cryopreservation as a fertility preservation option before undergoing treatment for recurrent breast cancer. A day after restarting letrozole treatment, the patient unexpectedly developed severe abdominal pain. Laparoscopic hemostasis was performed to manage the ovarian swelling and hemorrhage.

Conclusions

The ovaries can be restimulated by restart letrozole after an oocyte retrieval procedure. Therefore, reproductive-medicine practitioners should understand the potential complications of letrozole administration in such cases and take steps to ensure that they are minimized.

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Title: Severe hemoperitoneum resulting from restart of letrozole after oocyte retrieval procedure: a case report
Authors: Haipeng Huang
Yasushi Takai
Kouki Samejima
Yosuke Gomi
Tatsuya Narita
Shunichiro Ichinose
Yukiko Itaya
Yosihisa Ono
Sigetaka Matsunaga
Masahiro Saitoh
Hiroyuki Seki
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Fertility
Breast Cancer
Ovarian Hyperstimulation Syndrome
Breast Cancer
Letrozole
Estradiol
Published in: Journal of Medical Case Reports / Issue 1/2021
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/s13256-021-02938-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Severe hemoperitoneum resulting from restart of letrozole after oocyte retrieval procedure: a case report

Abstract

Background

Case presentation

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Case presentation

Conclusions

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