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Published in: Clinical and Translational Oncology 8/2020

01-08-2020 | Fentanyl | Review Article

Breakthrough cancer pain: review and calls to action to improve its management

Authors: C. Camps Herrero, N. Batista, N. Díaz Fernández, Y. Escobar Álvarez, A. Gonzalo Gómez, D. Isla Casado, A. Salud, J. Terrasa Pons, V. Guillem Porta

Published in: Clinical and Translational Oncology | Issue 8/2020

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Abstract

In this paper, we review the current state of breakthrough cancer pain (BTcP) management. BTcP is a heterogeneous condition and a global problem for cancer patients. It is often managed suboptimally, which results in a negative outcome for patients, healthcare providers, and healthcare systems. Several barriers to the appropriate management of BTcP have been identified. These include, among others, an incomplete definition of BTcP, poor training of healthcare providers and patients alike, a lack of a multidisciplinary approach and the absence of specific protocols and tools. We provide some actions to help physicians and patients improve their approach to BTcP, including specific training, the design of easy-to-use tools for BTcP identification and assessment (such as checklists and pocket-sized cards), individualized treatment, and the use of multidisciplinary teams.
Literature
1.
go back to reference Edwards BK, Brown ML, Wingo PA, Howe HL, Ward E, Ries LAG, et al. Annual report to the nation on the status of cancer, 1975–2002, featuring population-based trends in cancer treatment. J Natl Cancer Inst. 2005;97(19):1407–27.PubMed Edwards BK, Brown ML, Wingo PA, Howe HL, Ward E, Ries LAG, et al. Annual report to the nation on the status of cancer, 1975–2002, featuring population-based trends in cancer treatment. J Natl Cancer Inst. 2005;97(19):1407–27.PubMed
2.
go back to reference Margarit C, Juliá J, López R, Anton A, Escobar Y, Casas A, et al. Breakthrough cancer pain-still a challenge. J Pain Res. 2012;5:559–66.PubMedPubMedCentral Margarit C, Juliá J, López R, Anton A, Escobar Y, Casas A, et al. Breakthrough cancer pain-still a challenge. J Pain Res. 2012;5:559–66.PubMedPubMedCentral
3.
go back to reference González-Escalada JR, Camba A, Casas A, Gascón P, Herruzo I, Núñez-Olarte JM, et al. Código de buena práctica para el control del dolor oncológico. Revista de la Sociedad Española del Dolor. 2011;18(2):98–117. González-Escalada JR, Camba A, Casas A, Gascón P, Herruzo I, Núñez-Olarte JM, et al. Código de buena práctica para el control del dolor oncológico. Revista de la Sociedad Española del Dolor. 2011;18(2):98–117.
5.
6.
go back to reference Fallon M, Giusti R, Aielli F, Hoskin P, Rolke R, Sharma M, et al. Management of cancer pain in adult patients: ESMO Clinical Practice Guidelines. Ann Oncol. 2018;29(Supplement_4):iv166–iv191.PubMed Fallon M, Giusti R, Aielli F, Hoskin P, Rolke R, Sharma M, et al. Management of cancer pain in adult patients: ESMO Clinical Practice Guidelines. Ann Oncol. 2018;29(Supplement_4):iv166–iv191.PubMed
7.
go back to reference Mercadante S. Treating breakthrough pain in oncology. Expert Rev Anticancer Ther. 2018;18(5):445–9.PubMed Mercadante S. Treating breakthrough pain in oncology. Expert Rev Anticancer Ther. 2018;18(5):445–9.PubMed
8.
go back to reference Vellucci R, Mediati RD, Gasperoni S, Mammucari M, Marinangeli F, Romualdi P. Assessment and treatment of breakthrough cancer pain: from theory to clinical practice. J Pain Res. 2017;10:2147–55.PubMedPubMedCentral Vellucci R, Mediati RD, Gasperoni S, Mammucari M, Marinangeli F, Romualdi P. Assessment and treatment of breakthrough cancer pain: from theory to clinical practice. J Pain Res. 2017;10:2147–55.PubMedPubMedCentral
9.
go back to reference Mercadante S. Breakthrough pain in cancer patients: prevalence, mechanisms and treatment options. Curr Opin Anaesthesiol. 2015;28(5):559–64.PubMed Mercadante S. Breakthrough pain in cancer patients: prevalence, mechanisms and treatment options. Curr Opin Anaesthesiol. 2015;28(5):559–64.PubMed
10.
go back to reference Sabato AF. Idiopathic breakthrough pain: a new hypothesis. Clin Drug Investig. 2010;30(Suppl 2):27–9.PubMed Sabato AF. Idiopathic breakthrough pain: a new hypothesis. Clin Drug Investig. 2010;30(Suppl 2):27–9.PubMed
11.
go back to reference Fortner BV, Demarco G, Irving G, Ashley J, Keppler G, Chavez J, et al. Description and predictors of direct and indirect costs of pain reported by cancer patients. J Pain Symptom Manage. 2003;25(1):9–18.PubMed Fortner BV, Demarco G, Irving G, Ashley J, Keppler G, Chavez J, et al. Description and predictors of direct and indirect costs of pain reported by cancer patients. J Pain Symptom Manage. 2003;25(1):9–18.PubMed
12.
go back to reference Petzke F, Radbruch L, Zech D, Loick G, Grond S. Temporal presentation of chronic cancer pain: transitory pains on admission to a multidisciplinary pain clinic. J Pain Symptom Manage. 1999;17(6):391–401.PubMed Petzke F, Radbruch L, Zech D, Loick G, Grond S. Temporal presentation of chronic cancer pain: transitory pains on admission to a multidisciplinary pain clinic. J Pain Symptom Manage. 1999;17(6):391–401.PubMed
13.
go back to reference Portenoy RK, Payne D, Jacobsen P. Breakthrough pain: characteristics and impact in patients with cancer pain. Pain. 1999;81(1–2):129–34.PubMed Portenoy RK, Payne D, Jacobsen P. Breakthrough pain: characteristics and impact in patients with cancer pain. Pain. 1999;81(1–2):129–34.PubMed
14.
go back to reference Swanwick M, Haworth M, Lennard RF. The prevalence of episodic pain in cancer: a survey of hospice patients on admission. Palliat Med. 2001;15(1):9–18.PubMed Swanwick M, Haworth M, Lennard RF. The prevalence of episodic pain in cancer: a survey of hospice patients on admission. Palliat Med. 2001;15(1):9–18.PubMed
15.
go back to reference Deandrea S, Corli O, Consonni D, Villani W, Greco MT, Apolone G. Prevalence of breakthrough cancer pain: a systematic review and a pooled analysis of published literature. J Pain Symptom Manage. 2014;47(1):57–76.PubMed Deandrea S, Corli O, Consonni D, Villani W, Greco MT, Apolone G. Prevalence of breakthrough cancer pain: a systematic review and a pooled analysis of published literature. J Pain Symptom Manage. 2014;47(1):57–76.PubMed
16.
go back to reference Working Group Nientemale DEI, Vellucci R, Fanelli G, Pannuti R, Peruselli C, Adamo S, et al. What to do, and What not to do, When diagnosing and dreating breakthrough cancer pain (BTcP): expert opinion. Drugs. 2016;76(3):315–30.PubMedCentral Working Group Nientemale DEI, Vellucci R, Fanelli G, Pannuti R, Peruselli C, Adamo S, et al. What to do, and What not to do, When diagnosing and dreating breakthrough cancer pain (BTcP): expert opinion. Drugs. 2016;76(3):315–30.PubMedCentral
17.
go back to reference Yang P, Cheville AL, Wampfler JA, Garces YI, Jatoi A, Clark MM, et al. Quality of life and symptom burden among long-term lung cancer survivors. J Thorac Oncol. 2012;7(1):64–70.PubMedPubMedCentral Yang P, Cheville AL, Wampfler JA, Garces YI, Jatoi A, Clark MM, et al. Quality of life and symptom burden among long-term lung cancer survivors. J Thorac Oncol. 2012;7(1):64–70.PubMedPubMedCentral
18.
go back to reference American Pain Foundation n. Breakthrough cancer pain: mending the break in the continuum of care. J Pain Palliat Care Pharmacother. 2011;25(3):252–64. American Pain Foundation n. Breakthrough cancer pain: mending the break in the continuum of care. J Pain Palliat Care Pharmacother. 2011;25(3):252–64.
19.
go back to reference Davies A, Buchanan A, Zeppetella G, Porta-Sales J, Likar R, Weismayr W, et al. Breakthrough cancer pain: an observational study of 1000 European oncology patients. J Pain Symptom Manage. 2013;46(5):619–28.PubMed Davies A, Buchanan A, Zeppetella G, Porta-Sales J, Likar R, Weismayr W, et al. Breakthrough cancer pain: an observational study of 1000 European oncology patients. J Pain Symptom Manage. 2013;46(5):619–28.PubMed
20.
go back to reference Mantyh PW. Cancer pain and its impact on diagnosis, survival and quality of life. Nat Rev Neurosci. 2006;7(10):797–809.PubMed Mantyh PW. Cancer pain and its impact on diagnosis, survival and quality of life. Nat Rev Neurosci. 2006;7(10):797–809.PubMed
21.
go back to reference Perez-Hernandez C, Jimenez-Lopez AJ, Sanz-Yague A, Mar-Medina J, Larranaga I, Soler-Lopez B. Observational study evaluating the economic impact of breakthrough pain in cancer patients in clinical practice in Spain: the IMDI study. Pain Ther. 2018;7(2):227–40.PubMedPubMedCentral Perez-Hernandez C, Jimenez-Lopez AJ, Sanz-Yague A, Mar-Medina J, Larranaga I, Soler-Lopez B. Observational study evaluating the economic impact of breakthrough pain in cancer patients in clinical practice in Spain: the IMDI study. Pain Ther. 2018;7(2):227–40.PubMedPubMedCentral
22.
go back to reference Ruggeri M, Turriziani A, Oradei M. Cost-effectiveness analysis of transnasal fentanyl citrate for the treatment of breakthrough cancer pain. Expert Rev Pharmacoecon Outcomes Res. 2014;14(3):459–64.PubMed Ruggeri M, Turriziani A, Oradei M. Cost-effectiveness analysis of transnasal fentanyl citrate for the treatment of breakthrough cancer pain. Expert Rev Pharmacoecon Outcomes Res. 2014;14(3):459–64.PubMed
23.
go back to reference Fortner BV, Okon TA, Portenoy RK. A survey of pain-related hospitalizations, emergency department visits, and physician office visits reported by cancer patients with and without history of breakthrough pain. J Pain. 2002;3(1):38–44.PubMed Fortner BV, Okon TA, Portenoy RK. A survey of pain-related hospitalizations, emergency department visits, and physician office visits reported by cancer patients with and without history of breakthrough pain. J Pain. 2002;3(1):38–44.PubMed
24.
go back to reference Fortner BV, Okon TA, Ashley J, Kepler G, Chavez J, Tauer K, et al. The zero acceptance of pain (ZAP) quality improvement project: evaluation of pain severity, pain interference, global quality of life, and pain-related costs. J Pain Symptom Manage. 2003;25(4):334–43.PubMed Fortner BV, Okon TA, Ashley J, Kepler G, Chavez J, Tauer K, et al. The zero acceptance of pain (ZAP) quality improvement project: evaluation of pain severity, pain interference, global quality of life, and pain-related costs. J Pain Symptom Manage. 2003;25(4):334–43.PubMed
25.
go back to reference Mularski RA, White-Chu F, Overbay D, Miller L, Asch SM, Ganzini L. Measuring pain as the 5th vital sign does not improve quality of pain management. J Gen Intern Med. 2006;21(6):607–12.PubMedPubMedCentral Mularski RA, White-Chu F, Overbay D, Miller L, Asch SM, Ganzini L. Measuring pain as the 5th vital sign does not improve quality of pain management. J Gen Intern Med. 2006;21(6):607–12.PubMedPubMedCentral
26.
go back to reference Camps Herrero C, Reina Zoilo JJ, Monge Martín D, Caballero Martínez F, Guillem Porta V, Aranda Aguilar E, et al. Active study: undetected prevalence and clinical inertia in the treatment of breakthrough cancer pain (BTcP). Clin Transl Oncol. 2019;21(3):380–90.PubMed Camps Herrero C, Reina Zoilo JJ, Monge Martín D, Caballero Martínez F, Guillem Porta V, Aranda Aguilar E, et al. Active study: undetected prevalence and clinical inertia in the treatment of breakthrough cancer pain (BTcP). Clin Transl Oncol. 2019;21(3):380–90.PubMed
27.
go back to reference Escobar Álvarez Y, Biete i Solà A, Camba Rodríguez M, Gálvez Mateos R, Mañas Rueda A, Rodríguez Sánchez CA, et al. Diagnóstico y tratamiento del dolor irruptivo oncológico: recomendaciones de consenso. Revista de la Sociedad Española del Dolor. 2013;20(2):61–8. Escobar Álvarez Y, Biete i Solà A, Camba Rodríguez M, Gálvez Mateos R, Mañas Rueda A, Rodríguez Sánchez CA, et al. Diagnóstico y tratamiento del dolor irruptivo oncológico: recomendaciones de consenso. Revista de la Sociedad Española del Dolor. 2013;20(2):61–8.
28.
go back to reference García-Mata J, Álamo C, de Castro J, Contreras J, Gálvez R, Jara C, et al. A survey of perceptions, attitudes, knowledge and practices of medical oncologists about cancer pain management in Spain. Clin Transl Oncol. 2018;20(8):1061–71.PubMed García-Mata J, Álamo C, de Castro J, Contreras J, Gálvez R, Jara C, et al. A survey of perceptions, attitudes, knowledge and practices of medical oncologists about cancer pain management in Spain. Clin Transl Oncol. 2018;20(8):1061–71.PubMed
29.
go back to reference Association for Palliative Medicine of Great B 2009 The management of cancer-related breakthrough pain: recommendations of a task group of the Science Committee of the Association for Palliative Medicine of Great Britain and Ireland Eur J Pain. 13 4 331 338 Association for Palliative Medicine of Great B 2009 The management of cancer-related breakthrough pain: recommendations of a task group of the Science Committee of the Association for Palliative Medicine of Great Britain and Ireland Eur J Pain. 13 4 331 338
30.
go back to reference Mercadante S, Portenoy RK. Breakthrough cancer pain: twenty-five years of study. Pain. 2016;157(12):2657–63.PubMed Mercadante S, Portenoy RK. Breakthrough cancer pain: twenty-five years of study. Pain. 2016;157(12):2657–63.PubMed
31.
go back to reference Løhre ET, Klepstad P, Bennett MI, Brunelli C, Caraceni A, Fainsinger RL, et al. From "breakthrough" to "episodic" cancer pain? A European association for palliative care research network expert delphi survey toward a common terminology and classification of transient cancer pain exacerbations. J Pain Symptom Manage. 2016;51(6):1013–9.PubMed Løhre ET, Klepstad P, Bennett MI, Brunelli C, Caraceni A, Fainsinger RL, et al. From "breakthrough" to "episodic" cancer pain? A European association for palliative care research network expert delphi survey toward a common terminology and classification of transient cancer pain exacerbations. J Pain Symptom Manage. 2016;51(6):1013–9.PubMed
32.
go back to reference Jara C, Del Barco S, Gravalos C, Hoyos S, Hernandez B, Munoz M, et al. SEOM clinical guideline for treatment of cancer pain (2017). Clin Transl Oncol. 2018;20(1):97–107.PubMed Jara C, Del Barco S, Gravalos C, Hoyos S, Hernandez B, Munoz M, et al. SEOM clinical guideline for treatment of cancer pain (2017). Clin Transl Oncol. 2018;20(1):97–107.PubMed
33.
go back to reference Kwon JH. Overcoming barriers in cancer pain management. J Clin Oncol. 2014;32(16):1727–33.PubMed Kwon JH. Overcoming barriers in cancer pain management. J Clin Oncol. 2014;32(16):1727–33.PubMed
34.
go back to reference Breivik H, Cherny N, Collett B, de Conno F, Filbet M, Foubert AJ, et al. Cancer-related pain: a pan-European survey of prevalence, treatment, and patient attitudes. Ann Oncol. 2009;20(8):1420–33.PubMed Breivik H, Cherny N, Collett B, de Conno F, Filbet M, Foubert AJ, et al. Cancer-related pain: a pan-European survey of prevalence, treatment, and patient attitudes. Ann Oncol. 2009;20(8):1420–33.PubMed
35.
go back to reference Carulla Torrent J, Jara Sánchez C, Sanz Ortiz J, Batista López N, Camps Herrero C, Cassinello Espinosa J, et al. Oncologists' perceptions of cancer pain management in Spain: the real and the ideal. Eur J Pain. 2007;11(3):352–9.PubMed Carulla Torrent J, Jara Sánchez C, Sanz Ortiz J, Batista López N, Camps Herrero C, Cassinello Espinosa J, et al. Oncologists' perceptions of cancer pain management in Spain: the real and the ideal. Eur J Pain. 2007;11(3):352–9.PubMed
36.
go back to reference Kwon JH, Oh SY, Chisholm G, Lee J-A, Lee JJ, Park KW, et al. Predictors of high score patient-reported barriers to controlling cancer pain: a preliminary report. Support Care Cancer. 2013;21(4):1175–83.PubMed Kwon JH, Oh SY, Chisholm G, Lee J-A, Lee JJ, Park KW, et al. Predictors of high score patient-reported barriers to controlling cancer pain: a preliminary report. Support Care Cancer. 2013;21(4):1175–83.PubMed
37.
go back to reference Fallon M, Giusti R, Aielli F, Hoskin P, Rolke R, Sharma M, et al. Management of cancer pain in adult patients: ESMO Clinical Practice Guidelines†. Ann Oncol. 2018;29(Supplement_4):iv166–iv191.PubMed Fallon M, Giusti R, Aielli F, Hoskin P, Rolke R, Sharma M, et al. Management of cancer pain in adult patients: ESMO Clinical Practice Guidelines†. Ann Oncol. 2018;29(Supplement_4):iv166–iv191.PubMed
38.
go back to reference Vellucci R. Breakthrough cancer pain. Eur J Oncol. 2015;20(suppl 1):11–2. Vellucci R. Breakthrough cancer pain. Eur J Oncol. 2015;20(suppl 1):11–2.
39.
go back to reference Boceta J, De la Torre A, Samper D, Farto M, Sánchez-de la Rosa R. Consensus and controversies in the definition, assessment, treatment and monitoring of BTcP: results of a Delphi study. Clin Transl Oncol. 2016;18(11):1088–97.PubMedPubMedCentral Boceta J, De la Torre A, Samper D, Farto M, Sánchez-de la Rosa R. Consensus and controversies in the definition, assessment, treatment and monitoring of BTcP: results of a Delphi study. Clin Transl Oncol. 2016;18(11):1088–97.PubMedPubMedCentral
40.
go back to reference Webber K, Davies AN, Zeppetella G, Cowie MR. Development and validation of the breakthrough pain assessment tool (BAT) in cancer patients. J Pain Symptom Manage. 2014;48(4):619–31.PubMed Webber K, Davies AN, Zeppetella G, Cowie MR. Development and validation of the breakthrough pain assessment tool (BAT) in cancer patients. J Pain Symptom Manage. 2014;48(4):619–31.PubMed
41.
go back to reference Webber K, Davies AN, Cowie MR. Accuracy of a diagnostic algorithm to diagnose breakthrough cancer pain as compared with clinical assessment. J Pain Symptom Manage. 2015;50(4):495–500.PubMed Webber K, Davies AN, Cowie MR. Accuracy of a diagnostic algorithm to diagnose breakthrough cancer pain as compared with clinical assessment. J Pain Symptom Manage. 2015;50(4):495–500.PubMed
42.
go back to reference Fallon M, Walker J, Colvin L, Rodriguez A, Murray G, Sharpe M, et al. Pain management in cancer center inpatients: a cluster randomized trial to evaluate a systematic integrated approach-the edinburgh pain assessment and management tool. J Clin Oncol. 2018;36(13):1284–90.PubMedPubMedCentral Fallon M, Walker J, Colvin L, Rodriguez A, Murray G, Sharpe M, et al. Pain management in cancer center inpatients: a cluster randomized trial to evaluate a systematic integrated approach-the edinburgh pain assessment and management tool. J Clin Oncol. 2018;36(13):1284–90.PubMedPubMedCentral
43.
go back to reference Jacobsen PB, Snyder CF. Improving pain assessment and management in routine oncology practice: the role of implementation research. J Clin Oncol. 2018;36(13):1272–4.PubMed Jacobsen PB, Snyder CF. Improving pain assessment and management in routine oncology practice: the role of implementation research. J Clin Oncol. 2018;36(13):1272–4.PubMed
44.
go back to reference Porta-Sales J, Garzón Rodríguez C, Julià Torras J, Casals MM. Dolor irruptivo en cáncer. Med Clin (Barc). 2010;135(6):280–5.PubMed Porta-Sales J, Garzón Rodríguez C, Julià Torras J, Casals MM. Dolor irruptivo en cáncer. Med Clin (Barc). 2010;135(6):280–5.PubMed
45.
go back to reference Vissers DCJ, Lenre M, Tolley K, Jakobsson J, Sendersky V, Jansen JP. An economic evaluation of short-acting opioids for treatment of breakthrough pain in patients with cancer. Value Health. 2011;14(2):274–81.PubMed Vissers DCJ, Lenre M, Tolley K, Jakobsson J, Sendersky V, Jansen JP. An economic evaluation of short-acting opioids for treatment of breakthrough pain in patients with cancer. Value Health. 2011;14(2):274–81.PubMed
46.
go back to reference Caraceni A, Davies A, Poulain P, Cortes-Funes H, Panchal SJ, Fanelli G. Guidelines for the management of breakthrough pain in patients with cancer. J Natl Compr Canc Netw. 2013;11(Suppl 1):S29–36.PubMed Caraceni A, Davies A, Poulain P, Cortes-Funes H, Panchal SJ, Fanelli G. Guidelines for the management of breakthrough pain in patients with cancer. J Natl Compr Canc Netw. 2013;11(Suppl 1):S29–36.PubMed
47.
go back to reference Porta-Sales J, Pérez C, Escobar Y, Martínez V. Diagnosis and management of breakthrough cancer pain: Have all the questions been resolved? A Delphi-based consensus assessment (DOIRON). Clin Transl Oncol. 2016;18(9):945–54.PubMed Porta-Sales J, Pérez C, Escobar Y, Martínez V. Diagnosis and management of breakthrough cancer pain: Have all the questions been resolved? A Delphi-based consensus assessment (DOIRON). Clin Transl Oncol. 2016;18(9):945–54.PubMed
48.
go back to reference Álamo C, Zaragozá-Arnáez C, Noriega-Matanza C, M-Torres L. Fentanilo: una molécula y múltiples formulaciones galénicas de trascendencia clínica en el tratamiento del dolor irruptivo oncológico. Revista de la Sociedad Española del Dolor. 2017;24:188–200. Álamo C, Zaragozá-Arnáez C, Noriega-Matanza C, M-Torres L. Fentanilo: una molécula y múltiples formulaciones galénicas de trascendencia clínica en el tratamiento del dolor irruptivo oncológico. Revista de la Sociedad Española del Dolor. 2017;24:188–200.
49.
go back to reference Rauck R, North J, Gever LN, Tagarro I, Finn AL. Fentanyl buccal soluble film (FBSF) for breakthrough pain in patients with cancer: a randomized, double-blind, placebo-controlled study. Ann Oncol. 2010;21(6):1308–14.PubMed Rauck R, North J, Gever LN, Tagarro I, Finn AL. Fentanyl buccal soluble film (FBSF) for breakthrough pain in patients with cancer: a randomized, double-blind, placebo-controlled study. Ann Oncol. 2010;21(6):1308–14.PubMed
50.
go back to reference Buchanan A, Davies A, Geerling J. Breakthrough cancer pain: the role of the nurse. Int J Palliat Nurs. 2014;20(3):126–9.PubMed Buchanan A, Davies A, Geerling J. Breakthrough cancer pain: the role of the nurse. Int J Palliat Nurs. 2014;20(3):126–9.PubMed
51.
go back to reference Vallerand AH, Musto S, Polomano RC. Nursing's role in cancer pain management. Curr Pain Headache Rep. 2011;15(4):250–62.PubMed Vallerand AH, Musto S, Polomano RC. Nursing's role in cancer pain management. Curr Pain Headache Rep. 2011;15(4):250–62.PubMed
52.
go back to reference Wengstrom Y, Geerling J, Rustoen T. European Oncology Nursing Society breakthrough cancer pain guidelines. Eur J Oncol Nurs. 2014;18(2):127–31.PubMed Wengstrom Y, Geerling J, Rustoen T. European Oncology Nursing Society breakthrough cancer pain guidelines. Eur J Oncol Nurs. 2014;18(2):127–31.PubMed
53.
go back to reference Mercadante S, Adile C, Torta R, Varetto A, Fulfaro F, Giarratano A, et al. Meaningful cut-off pain intensity for breakthrough pain changes in advanced cancer patients. Curr Med Res Opin. 2013;29(1):93–7.PubMed Mercadante S, Adile C, Torta R, Varetto A, Fulfaro F, Giarratano A, et al. Meaningful cut-off pain intensity for breakthrough pain changes in advanced cancer patients. Curr Med Res Opin. 2013;29(1):93–7.PubMed
54.
go back to reference Mercadante S, Cuomo A. Breakthrough cancer pain: ten commandments. Value Health. 2016;19(5):531–6.PubMed Mercadante S, Cuomo A. Breakthrough cancer pain: ten commandments. Value Health. 2016;19(5):531–6.PubMed
56.
go back to reference López López R, Camps Herrero C, Khosravi-Shahi P, Guillem Porta V, Carrato Mena A, Garcia-Foncillas J, et al. Oncologist's knowledge and implementation of guidelines for breakthrough cancer pain in Spain: CONOCE study. Clin Transl Oncol. 2018;20(5):613–8.PubMed López López R, Camps Herrero C, Khosravi-Shahi P, Guillem Porta V, Carrato Mena A, Garcia-Foncillas J, et al. Oncologist's knowledge and implementation of guidelines for breakthrough cancer pain in Spain: CONOCE study. Clin Transl Oncol. 2018;20(5):613–8.PubMed
57.
go back to reference O'Hagan P, Mercadante S. Breakthrough cancer pain: the importance of the right treatment at the right time. Eur J Pain. 2018;22(7):1362–74.PubMed O'Hagan P, Mercadante S. Breakthrough cancer pain: the importance of the right treatment at the right time. Eur J Pain. 2018;22(7):1362–74.PubMed
58.
go back to reference Caraceni A, Martini C, Zecca E, Portenoy RK, Ashby MA, Hawson G, et al. Breakthrough pain characteristics and syndromes in patients with cancer pain. An international survey. Palliat Med. 2004;18(3):177–83.PubMed Caraceni A, Martini C, Zecca E, Portenoy RK, Ashby MA, Hawson G, et al. Breakthrough pain characteristics and syndromes in patients with cancer pain. An international survey. Palliat Med. 2004;18(3):177–83.PubMed
60.
go back to reference Davies AN, Elsner F, Filbet MJ, Porta-Sales J, Ripamonti C, Santini D, et al. Breakthrough cancer pain (BTcP) management: a review of international and national guidelines. BMJ Support Palliat Care. 2018;8(3):241–9.PubMed Davies AN, Elsner F, Filbet MJ, Porta-Sales J, Ripamonti C, Santini D, et al. Breakthrough cancer pain (BTcP) management: a review of international and national guidelines. BMJ Support Palliat Care. 2018;8(3):241–9.PubMed
61.
go back to reference Camps C, Rubio ED, Lopez R, Carrato A, Gascon P, Margarita F, et al. The quality oncology practice initiative program: experience in Spain. J Clin Oncol. 2017;35(8_suppl):214. Camps C, Rubio ED, Lopez R, Carrato A, Gascon P, Margarita F, et al. The quality oncology practice initiative program: experience in Spain. J Clin Oncol. 2017;35(8_suppl):214.
62.
go back to reference Dubois MY, Follett KA. Pain medicine: The case for an independent medical specialty and training programs. Acad Med. 2014;89(6):863–8.PubMed Dubois MY, Follett KA. Pain medicine: The case for an independent medical specialty and training programs. Acad Med. 2014;89(6):863–8.PubMed
63.
go back to reference Sabia M, Weaver M, Gessman R, Kalariya J. Update on the importance of medical education in the changing field of pain medicine. J Anesthesia Patient Care. 2017;2:1–5. Sabia M, Weaver M, Gessman R, Kalariya J. Update on the importance of medical education in the changing field of pain medicine. J Anesthesia Patient Care. 2017;2:1–5.
64.
go back to reference Kuip EJ, Zandvliet ML, Koolen SL, Mathijssen RH, van der Rijt CC. A review of factors explaining variability in fentanyl pharmacokinetics; focus on implications for cancer patients. Br J Clin Pharmacol. 2017;83(2):294–313.PubMed Kuip EJ, Zandvliet ML, Koolen SL, Mathijssen RH, van der Rijt CC. A review of factors explaining variability in fentanyl pharmacokinetics; focus on implications for cancer patients. Br J Clin Pharmacol. 2017;83(2):294–313.PubMed
65.
go back to reference Daeninck P, Gagnon B, Gallagher R, Henderson JD, Shir Y, Zimmermann C, et al. Canadian recommendations for the management of breakthrough cancer pain. Curr Oncol. 2016;23(2):96–108.PubMedPubMedCentral Daeninck P, Gagnon B, Gallagher R, Henderson JD, Shir Y, Zimmermann C, et al. Canadian recommendations for the management of breakthrough cancer pain. Curr Oncol. 2016;23(2):96–108.PubMedPubMedCentral
Metadata
Title
Breakthrough cancer pain: review and calls to action to improve its management
Authors
C. Camps Herrero
N. Batista
N. Díaz Fernández
Y. Escobar Álvarez
A. Gonzalo Gómez
D. Isla Casado
A. Salud
J. Terrasa Pons
V. Guillem Porta
Publication date
01-08-2020
Publisher
Springer International Publishing
Keyword
Fentanyl
Published in
Clinical and Translational Oncology / Issue 8/2020
Print ISSN: 1699-048X
Electronic ISSN: 1699-3055
DOI
https://doi.org/10.1007/s12094-019-02268-8

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