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Published in: Techniques in Coloproctology 10/2023

08-05-2023 | Fecal Incontinence | Original Article

Mucosal vs. cutaneous advancement flaps for the treatment of chronic anal fissures: a randomized clinical trial

Authors: M. S. Najafi, A. Kazemeini, S. M. Meshkati Yazd, M. Dashtkuhi, S. M. Ahmadi Tafti, B. Behboudi, M. S. Fazeli, A. Keshvari, M. R. Keramati

Published in: Techniques in Coloproctology | Issue 10/2023

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Abstract

Purpose

The aim of this study was to compare two surgical treatment methods for chronic anal fissures (CAF), mucosal advancement flap anoplasty (MAFA) and cutaneous advancement flap anoplasty (CAFA).

Methods

A randomized, blinded clinical trial was conducted on patients with CAF refractory to medical treatment referred to a tertiary-level hospital between January 2021 and December 2022. The patients were assigned to two groups by block randomization and were compared in terms of outcome, pain reduction, and complications.

Results

There were 30 patients (male to female ratio 2:3, median age 42 years [range 25–59 years]). Both techniques reduced anal pain significantly (p = 0.001); however, there were no significant differences between MAFA and CAFA groups in recurrence, duration of healing, postoperative pain, and postoperative bleeding. No patient suffered from fecal incontinence (Wexner score = 0) or flap necrosis postoperatively. Only two patients in the MAFA group (1 and 3 months after surgery) and one patient in the CAFA group (2 months after surgery) had recurrence (total recurrence rate = 10%, healing rate = 90%). All of the patients were satisfied with their surgical results.

Conclusion

Mucosal and cutaneous anal advancement flap techniques are effective and comparable surgical procedures for the treatment of chronic anal fissures with minimal complications, fast healing process, and minimal postoperative pain and complications.

Clinical trial ID

IRCT20120129008861N4 (www.​irct.​ir).
Literature
1.
go back to reference Gardner IH, Siddharthan RV, Tsikitis VL (2020) Benign anorectal disease: hemorrhoids, fissures, and fistulas. Ann Gastroenterol 33(1):9–18PubMed Gardner IH, Siddharthan RV, Tsikitis VL (2020) Benign anorectal disease: hemorrhoids, fissures, and fistulas. Ann Gastroenterol 33(1):9–18PubMed
3.
go back to reference Nelson RL, Abcarian H, Davis FG, Persky V (1995) Prevalence of benign anorectal disease in a randomly selected population. Dis Colon Rectum 38(4):341–344CrossRefPubMed Nelson RL, Abcarian H, Davis FG, Persky V (1995) Prevalence of benign anorectal disease in a randomly selected population. Dis Colon Rectum 38(4):341–344CrossRefPubMed
4.
go back to reference Madalinski MH (2011) Identifying the best therapy for chronic anal fissure. World J Gastroint Pharmacol Ther 2(2):9–16CrossRef Madalinski MH (2011) Identifying the best therapy for chronic anal fissure. World J Gastroint Pharmacol Ther 2(2):9–16CrossRef
5.
go back to reference Gosselink MP, Darby M, Zimmerman D, Gruss H, Schouten WR (2005) Treatment of chronic anal fissure by application of L-arginine gel: a phase II study in 15 patients. Dis Col Rectum 48(4):832–837CrossRef Gosselink MP, Darby M, Zimmerman D, Gruss H, Schouten WR (2005) Treatment of chronic anal fissure by application of L-arginine gel: a phase II study in 15 patients. Dis Col Rectum 48(4):832–837CrossRef
6.
go back to reference Kua KB, Kocher HM, Kelkar A, Patel AG (2001) Effect of topical glyceryl trinitrate on anodermal blood flow in patients with chronic anal fissures. ANZ J Surg 71(9):548–550CrossRefPubMed Kua KB, Kocher HM, Kelkar A, Patel AG (2001) Effect of topical glyceryl trinitrate on anodermal blood flow in patients with chronic anal fissures. ANZ J Surg 71(9):548–550CrossRefPubMed
7.
go back to reference Nelson RL (2014) Anal fissure (chronic). BMJ Clin Evid 2014;2014:0407. Nelson RL (2014) Anal fissure (chronic). BMJ Clin Evid 2014;2014:0407.
8.
go back to reference Shub HA, Salvati EP, Rubin RJ (1978) Conservative treatment of anal fissure: an unselected, retrospective and continuous study. Dis Colon Rectum 21(8):582–583CrossRefPubMed Shub HA, Salvati EP, Rubin RJ (1978) Conservative treatment of anal fissure: an unselected, retrospective and continuous study. Dis Colon Rectum 21(8):582–583CrossRefPubMed
10.
go back to reference Beaty JS, Shashidharan M (2016) Anal fissure. Clin Colon Rectal Surg 29(01):030–037CrossRef Beaty JS, Shashidharan M (2016) Anal fissure. Clin Colon Rectal Surg 29(01):030–037CrossRef
12.
go back to reference Perry WB, Dykes SL, Buie WD et al (2010) Practice parameters for the management of anal fissures. Dis Col Rect 53(8):1110–1115CrossRef Perry WB, Dykes SL, Buie WD et al (2010) Practice parameters for the management of anal fissures. Dis Col Rect 53(8):1110–1115CrossRef
13.
14.
go back to reference Richard C, Gregoire R, Plewes E et al (2000) Internal sphincterotomy is superior to topical nitroglycerin in the treatment of chronic anal fissure: results of a randomized, controlled trial by the Canadian Colorectal Surgical Trials Group. Dis Colon Rectum 43(8):1048–1055CrossRefPubMed Richard C, Gregoire R, Plewes E et al (2000) Internal sphincterotomy is superior to topical nitroglycerin in the treatment of chronic anal fissure: results of a randomized, controlled trial by the Canadian Colorectal Surgical Trials Group. Dis Colon Rectum 43(8):1048–1055CrossRefPubMed
15.
go back to reference Patti R, Famà F, Barrera T, Migliore G, Di Vita G (2010) Fissurectomy and anal advancement flap for anterior chronic anal fissure without hypertonia of the internal anal sphincter in females. Colorectal Dis 12(11):1127–1130CrossRefPubMed Patti R, Famà F, Barrera T, Migliore G, Di Vita G (2010) Fissurectomy and anal advancement flap for anterior chronic anal fissure without hypertonia of the internal anal sphincter in females. Colorectal Dis 12(11):1127–1130CrossRefPubMed
16.
go back to reference Patti R, Famà F, Tornambè A, Asaro G, Di Vita G (2010) Fissurectomy combined with anoplasty and injection of botulinum toxin in treatment of anterior chronic anal fissure with hypertonia of internal anal sphincter: a pilot study. Tech Coloproctol 14(1):31–36CrossRefPubMed Patti R, Famà F, Tornambè A, Asaro G, Di Vita G (2010) Fissurectomy combined with anoplasty and injection of botulinum toxin in treatment of anterior chronic anal fissure with hypertonia of internal anal sphincter: a pilot study. Tech Coloproctol 14(1):31–36CrossRefPubMed
17.
go back to reference Nyam D, Wilson R, Stewart K, Farouk R, Bartolo DC (1995) Island advancement flaps in the management of anal fissures. Br J Surg 82(3):326–328CrossRefPubMed Nyam D, Wilson R, Stewart K, Farouk R, Bartolo DC (1995) Island advancement flaps in the management of anal fissures. Br J Surg 82(3):326–328CrossRefPubMed
18.
go back to reference Singh M, Sharma A, Gardiner A, Duthie GS (2005) Early results of a rotational flap to treat chronic anal fissures. Int J Colorectal Dis 20(4):339–342CrossRefPubMed Singh M, Sharma A, Gardiner A, Duthie GS (2005) Early results of a rotational flap to treat chronic anal fissures. Int J Colorectal Dis 20(4):339–342CrossRefPubMed
19.
go back to reference Chambers W, Sajal R, Dixon A (2010) V-Y advancement flap as first-line treatment for all chronic anal fissures. Int J Colorectal Dis 25(5):645–648CrossRefPubMed Chambers W, Sajal R, Dixon A (2010) V-Y advancement flap as first-line treatment for all chronic anal fissures. Int J Colorectal Dis 25(5):645–648CrossRefPubMed
20.
go back to reference Jorge JM, Wexner SD (1993) Etiology and management of fecal incontinence. Dis Colon Rectum 36(1):77–97CrossRefPubMed Jorge JM, Wexner SD (1993) Etiology and management of fecal incontinence. Dis Colon Rectum 36(1):77–97CrossRefPubMed
22.
go back to reference Ouaïssi M, Giger U, Sielezneff I et al (2011) Mucosal advancement flap anoplasty for chronic anal fissure resistant to conservative therapy. World J Surg 35(4):900–904CrossRefPubMed Ouaïssi M, Giger U, Sielezneff I et al (2011) Mucosal advancement flap anoplasty for chronic anal fissure resistant to conservative therapy. World J Surg 35(4):900–904CrossRefPubMed
23.
go back to reference Hancke E, Suchan K, Voelke K (2021) Anocutaneous advancement flap provides a quicker cure than fissurectomy in surgical treatment for chronic anal fissure a retrospective, observational study. Langenbecks Arch Surg 406(8):2861–2867CrossRefPubMedPubMedCentral Hancke E, Suchan K, Voelke K (2021) Anocutaneous advancement flap provides a quicker cure than fissurectomy in surgical treatment for chronic anal fissure a retrospective, observational study. Langenbecks Arch Surg 406(8):2861–2867CrossRefPubMedPubMedCentral
24.
go back to reference World Medical Association Declaration of Helsinki (2013) Ethical principles for medical research involving human subjects. JAMA 310(20):2191–2194CrossRef World Medical Association Declaration of Helsinki (2013) Ethical principles for medical research involving human subjects. JAMA 310(20):2191–2194CrossRef
25.
go back to reference Giordano P, Gravante G, Grondona P, Ruggiero B, Porrett T, Lunniss PJ (2009) Simple cutaneous advancement flap anoplasty for resistant chronic anal fissure: a prospective study. World J Surg 33(5):1058–1063CrossRefPubMed Giordano P, Gravante G, Grondona P, Ruggiero B, Porrett T, Lunniss PJ (2009) Simple cutaneous advancement flap anoplasty for resistant chronic anal fissure: a prospective study. World J Surg 33(5):1058–1063CrossRefPubMed
26.
go back to reference Patti R, Guercio G, Territo V, Aiello P, Angelo GL, Di Vita G (2012) Advancement flap in the management of chronic anal fissure: a prospective study. Updates Surg 64(2):101–106CrossRefPubMed Patti R, Guercio G, Territo V, Aiello P, Angelo GL, Di Vita G (2012) Advancement flap in the management of chronic anal fissure: a prospective study. Updates Surg 64(2):101–106CrossRefPubMed
27.
go back to reference Hancke E (2020) Sphinkterschonende operative therapie der chronischen analfissur durch primäre plastische deckung. Coloproctology 42(6):469–477CrossRef Hancke E (2020) Sphinkterschonende operative therapie der chronischen analfissur durch primäre plastische deckung. Coloproctology 42(6):469–477CrossRef
28.
go back to reference Magdy A, El Nakeeb A, Fouda EY, Youssef M, Farid M (2012) Comparative study of conventional lateral internal sphincterotomy, V-Y anoplasty, and tailored lateral internal sphincterotomy with V-Y anoplasty in the treatment of chronic anal fissure. J Gastrointest Surg 16(10):1955–1962CrossRefPubMed Magdy A, El Nakeeb A, Fouda EY, Youssef M, Farid M (2012) Comparative study of conventional lateral internal sphincterotomy, V-Y anoplasty, and tailored lateral internal sphincterotomy with V-Y anoplasty in the treatment of chronic anal fissure. J Gastrointest Surg 16(10):1955–1962CrossRefPubMed
29.
go back to reference Theodoropoulos GE, Spiropoulos V, Bramis K, Plastiras A, Zografos G (2015) Dermal flap advancement combined with conservative sphincterotomy in the treatment of chronic anal fissure. Am Surg 81(2):133–142CrossRefPubMed Theodoropoulos GE, Spiropoulos V, Bramis K, Plastiras A, Zografos G (2015) Dermal flap advancement combined with conservative sphincterotomy in the treatment of chronic anal fissure. Am Surg 81(2):133–142CrossRefPubMed
Metadata
Title
Mucosal vs. cutaneous advancement flaps for the treatment of chronic anal fissures: a randomized clinical trial
Authors
M. S. Najafi
A. Kazemeini
S. M. Meshkati Yazd
M. Dashtkuhi
S. M. Ahmadi Tafti
B. Behboudi
M. S. Fazeli
A. Keshvari
M. R. Keramati
Publication date
08-05-2023
Publisher
Springer International Publishing
Published in
Techniques in Coloproctology / Issue 10/2023
Print ISSN: 1123-6337
Electronic ISSN: 1128-045X
DOI
https://doi.org/10.1007/s10151-023-02810-5

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