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01-12-2011 | Healthcare Policy and Outcomes

Features Associated with Successful Recruitment of Diverse Patients onto Cancer Clinical Trials: Report from the American College of Surgeons Oncology Group

Authors: Kathleen M. Diehl, MD, FACS, Erin M. Green, Armin Weinberg, PhD, Wayne A. Frederick, MD, FACS, Dennis R. Holmes, MD, FACS, Bettye Green, Arden Morris, MD, FACS, Henry M. Kuerer, MD, PhD, FACS, Robert A. Beltran, MD, MBA, Jane Mendez, MD, FACS, Venus Gines, David M. Ota, MD, FACS, Heidi Nelson, MD, FACS, Lisa A. Newman, MD, MPH, FACS

Published in: Annals of Surgical Oncology | Issue 13/2011

Abstract

Background

The clinical trials mechanism of standardized treatment and follow-up for cancer patients with similar stages and patterns of disease is the most powerful approach available for evaluating the efficacy of novel therapies, and clinical trial participation should protect against delivery of care variations associated with racial/ethnic identity and/or socioeconomic status. Unfortunately, disparities in clinical trial accrual persist, with African Americans (AA) and Hispanic/Latino Americans (HA) underrepresented in most studies.

Study Design

We evaluated the accrual patterns for 10 clinical trials conducted by the American College of Surgeons Oncology Group (ACOSOG) 1999–2009, and analyzed results by race/ethnicity as well as by study design.

Results

Eight of 10 protocols were successful in recruiting AA and/or HA participants; three of four randomized trials were successful. Features that were present among all of the successfully recruiting protocols were: (1) studies designed to recruit patients with regional or advanced-stage disease (2 of 2 protocols); and (2) studies that involved some investigational systemic therapy (3 of 3 protocols).

Discussion

AA and HA cancer patients can be successfully accrued onto randomized clinical trials, but study design affects recruitment patterns. Increased socioeconomic disadvantages observed within minority-ethnicity communities results in barriers to screening and more advanced cancer stage distribution. Improving cancer early detection is critical in the effort to eliminate outcome disparities but existing differences in disease burden results in diminished eligibility for early-stage cancer clinical trials among minority-ethnicity patients.

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Title: Features Associated with Successful Recruitment of Diverse Patients onto Cancer Clinical Trials: Report from the American College of Surgeons Oncology Group
Authors: Kathleen M. Diehl, MD, FACS
Erin M. Green
Armin Weinberg, PhD
Wayne A. Frederick, MD, FACS
Dennis R. Holmes, MD, FACS
Bettye Green
Arden Morris, MD, FACS
Henry M. Kuerer, MD, PhD, FACS
Robert A. Beltran, MD, MBA
Jane Mendez, MD, FACS
Venus Gines
David M. Ota, MD, FACS
Heidi Nelson, MD, FACS
Lisa A. Newman, MD, MPH, FACS
Publication date: 01-12-2011
Publisher: Springer-Verlag
Published in: Annals of Surgical Oncology / Issue 13/2011
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-011-1818-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Features Associated with Successful Recruitment of Diverse Patients onto Cancer Clinical Trials: Report from the American College of Surgeons Oncology Group

Abstract

Background

Study Design

Results

Discussion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Study Design

Results

Discussion

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