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Molecular Imaging and Biology

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01-04-2011 | Research Article

Feasibility of Assessing [¹⁸F]FDG Lung Metabolism with Late Dynamic PET Imaging

Authors: Eric Laffon, Henri de Clermont, Jean-Marc Vernejoux, Jacques Jougon, Roger Marthan

Published in: Molecular Imaging and Biology | Issue 2/2011

Abstract

Purpose

The aim of this work was to non-invasively establish the feasibility of assessing 2-deoxy-2-[¹⁸F]fluoro-D-glucose (¹⁸F-FDG) lung metabolism with the use of a late dynamic positron emission tomograpy (PET) acquisition, i.e., beyond 2 h after injection.

Procedures

The present method has been probed in 11 patients without any respiratory disease, under fasting conditions, by assessing mean values of ¹⁸F-FDG lung metabolism. A kinetic model analysis has been implemented on a simple calculation sheet. An arbitrary (population based) input function has been used in each individual, which was obtained from literature data.

Results

In the healthy lung, no ¹⁸F-FDG release was found, and the mean values (±SD) of the ¹⁸F-FDG uptake rate constant and of the fraction of the free tracer in blood and interstitial volume were: K = 0.0016 min⁻¹ (±0.0005), and F = 0.18 (±0.10), respectively. These results were in very close agreement with literature data that were obtained by both three-compartment model analysis and Patlak graphical analysis (gold standards), and that used an invasive blood sampling. Furthermore, K and the standard uptake value index have been compared.

Conclusion

We conclude that assessing lung metabolism of ¹⁸F-FDG in humans with the use of late dynamic PET imaging is feasible. The arbitrary input function of this non-invasive feasibility study could be replaced in further experiments by an input function obtained by arterial sampling. It is suggested that this method may prove useful to quantify ¹⁸F-FDG lung metabolism under pathological conditions.

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Title: Feasibility of Assessing [18F]FDG Lung Metabolism with Late Dynamic PET Imaging
Authors: Eric Laffon
Henri de Clermont
Jean-Marc Vernejoux
Jacques Jougon
Roger Marthan
Publication date: 01-04-2011
Publisher: Springer-Verlag
Published in: Molecular Imaging and Biology / Issue 2/2011
Print ISSN: 1536-1632
Electronic ISSN: 1860-2002
DOI: https://doi.org/10.1007/s11307-010-0345-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Feasibility of Assessing [¹⁸F]FDG Lung Metabolism with Late Dynamic PET Imaging

Abstract

Purpose

Procedures

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Procedures

Results

Conclusion

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