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European Journal of Pediatrics
Published in: European Journal of Pediatrics 4/2006

01-04-2006 | Short Report

Fatal varicella infection in a girl with systemic lupus erythematosus after oral acyclovir prophylaxis

Authors: Izumi Hirose, Hideaki Ymamaguchi, Daijyo Inaguma, Kenzo Ono, Satoko Shimada, Jun-ichi Kawada, Kimiyasu Shiraki, Hiroshi Kimura

Published in: European Journal of Pediatrics | Issue 4/2006

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Excerpt

A fatal varicella infection in a 13-year-old girl with systemic lupus erythematosus (SLE) after oral acyclovir prophylaxis is reported. The patient was receiving oral prednisolone and azathioprine as a maintenance therapy. On July 5, 2003, the patient’s older sister developed varicella. Since the patient had a negative history for varicella and varicella-zoster virus (VZV) vaccination, she received prophylactic oral acyclovir (1000 mg q.i.d., or 4000 mg/day total) for 7 days. The prophylaxis was initiated 7 days after the initial exposure. …
Literature
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American Academy of Pediatrics (2003) Varicella-zoster infections In: Pickering LK (ed) Red Book: 2003 Report of the committee on infectious diseases. American Academy of Pediatrics, Elk Grove Village, pp 672–686
2.
Asano Y, Yoshikawa T, Suga S, Kobayashi I, Nakashima T, Yazaki T, Ozaki T, Yamada A, Imanishi J (1993) Postexposure prophylaxis of varicella in family contact by oral acyclovir. Pediatrics 92:219–222PubMed
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Gershon AA, LaRussa P (2004) Varicella-zoster virus infections In: Katz SL, Gershon AA, Hotez PJ (eds) Krugman’s infectious diseases of children. Mosby, Philadelphia pp 785–816
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Goldstein SL, Somers MJ, Lande MB, Brewer ED, Jabs KL (2000) Acyclovir prophylaxis of varicella in children with renal disease receiving steroids. Pediatr Nephrol 14:305–308PubMedCrossRef
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Ishida Y, Tauchi H, Higaki A, Yokota-Outou Y, Kida K (1996) Postexposure prophylaxis of varicella in children with leukemia by oral acyclovir. Pediatrics 97:150–151PubMed
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Kimura H, Kido S, Ozaki T, Tanaka N, Ito Y, Williams RK, Morishima T (2000) Comparison of quantitations of viral load in varicella and zoster. J Clin Microbiol 38:2447–2449PubMed
Metadata
Title
Fatal varicella infection in a girl with systemic lupus erythematosus after oral acyclovir prophylaxis
Authors
Izumi Hirose
Hideaki Ymamaguchi
Daijyo Inaguma
Kenzo Ono
Satoko Shimada
Jun-ichi Kawada
Kimiyasu Shiraki
Hiroshi Kimura
Publication date
01-04-2006
Publisher
Springer-Verlag
Published in
European Journal of Pediatrics / Issue 4/2006
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-005-0066-z

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