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Pediatric Rheumatology
Published in: Pediatric Rheumatology 1/2012

Open Access 01-12-2012 | Case Report

Fatal myocarditis in a child with systemic onset juvenile idiopathic arthritis during treatment with an interleukin 1 receptor antagonist

Authors: Andrew S Zeft, Shaji C Menon, Dylan Miller

Published in: Pediatric Rheumatology | Issue 1/2012

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Abstract

Background

The pathologic diagnosis of isolated myocarditis without pericardial involvement is uncommonly encountered in systemic onset Juvenile Idiopathic Arthritis (soJIA).

Case

An eleven year-old boy with soJIA died suddenly while being treated with the interleukin 1 (IL-1) receptor inhibitor, anakinra. His autopsy revealed an enlarged heart and microscopic findings were consistent with myocarditis, but not pericarditis. Viral PCR testing performed on his myocardial tissue was negative.

Conclusion

This case illustrates myocarditis as a fatal complication of soJIA, potentially enabled by anakinra.
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Metadata
Title
Fatal myocarditis in a child with systemic onset juvenile idiopathic arthritis during treatment with an interleukin 1 receptor antagonist
Authors
Andrew S Zeft
Shaji C Menon
Dylan Miller
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Pediatric Rheumatology / Issue 1/2012
Electronic ISSN: 1546-0096
DOI
https://doi.org/10.1186/1546-0096-10-8

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