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Indian Journal of Pediatrics
Published in: Indian Journal of Pediatrics 3/2019

01-03-2019 | Scientific Letter

Fatal Agranulocytosis and Fournier’s Gangrene due to the Use of Metamizole

Authors: Nagehan Aslan, Dincer Yildizdas, Ozden Ozgur Horoz, Onder Ozden

Published in: Indian Journal of Pediatrics | Issue 3/2019

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Excerpt

To the Editor: Metamizole Na (Novalgin®) is commonly used as an antipyretic, analgesic, and spasmolytic agent. There are reports of agranulocytosis in the literature even after the intake of a single dose of metamizole [1]. The aim of our case presentation is to draw attention to this severe side-effect of metamizole. …
Literature
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Blake FG, Winternitz MC, Geiger AJ, Leonard JC, Opper L. Yale case studies: agranulocyticanjina. Yale J Biol Med. 1935;7:465–71.PubMedCentralPubMed
2.
Salama A, Schtz B, Kiefel V, et al. Immune-mediated agranulocytosis related to drugs and their metabolites: mode of sensitization and heterogeneity of antibodies. Br J Haematol. 1989;72:127–32.CrossRefPubMed
3.
Stammschulte T, Ludwig WD, Muhlbauer B, et al. Metamizole (dipyrone)-associated agranulocytosis. An analysis of German spontaneous reports 1990-2012. Eur J Clin Pharmacol. 2015;71:1129–38.CrossRefPubMed
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Safioleas MC, Stamatakos MC, Diab AI, Safioleas PM. The use of oxygen in Fournier’s gangrene. Saudi Med J. 2006;27:1748–50.PubMed
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Winkler A, Kiets S, Bahlmann H, et al. GM-CSF as successful salvage therapy of metamizole (dypirone) induced agranulocytosis with Fournier’s gangrene and severe septic shock in an adolescent. Clin Case Rep. 2016;4:816–9.CrossRefPubMedCentralPubMed
Metadata
Title
Fatal Agranulocytosis and Fournier’s Gangrene due to the Use of Metamizole
Authors
Nagehan Aslan
Dincer Yildizdas
Ozden Ozgur Horoz
Onder Ozden
Publication date
01-03-2019
Publisher
Springer India
Published in
Indian Journal of Pediatrics / Issue 3/2019
Print ISSN: 0019-5456
Electronic ISSN: 0973-7693
DOI
https://doi.org/10.1007/s12098-018-2799-5

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