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01-07-2010 | Case Report

Far-distant metastases along the CSF pathway of glioblastoma multiforme during continuous low-dose chemotherapy with temozolomide and celecoxib

Authors: Marcel Seiz, Ingo Nölte, Ioannis Pechlivanis, Christian F. Freyschlag, Kirsten Schmieder, Peter Vajkoczy, Jochen Tuettenberg

Published in: Neurosurgical Review | Issue 3/2010

Abstract

Glioblastoma multiforme is the most common and most malignant primary brain tumour. Prognosis after diagnosis remains poor despite recent advances in adjuvant therapy. Treatment of choice is gross surgical resection and combined radio-chemotherapy with temozolomide as chemotherapeutic agent. Experimental continuous low-dose chemotherapy with temozolomide in combination with a cyclooxygenase-2 inhibitor has shown encouraging effects on progression-free survival and overall survival in patients, but leads to a high proportion of distant recurrences. Here, we describe extreme far-distant metastases along the neural axis of glioblastoma multiforme in four patients receiving metronomic antiangiogenic chemotherapy and review the literature to discuss possible mechanisms.

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Title: Far-distant metastases along the CSF pathway of glioblastoma multiforme during continuous low-dose chemotherapy with temozolomide and celecoxib
Authors: Marcel Seiz
Ingo Nölte
Ioannis Pechlivanis
Christian F. Freyschlag
Kirsten Schmieder
Peter Vajkoczy
Jochen Tuettenberg
Publication date: 01-07-2010
Publisher: Springer-Verlag
Published in: Neurosurgical Review / Issue 3/2010
Print ISSN: 0344-5607
Electronic ISSN: 1437-2320
DOI: https://doi.org/10.1007/s10143-010-0253-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Far-distant metastases along the CSF pathway of glioblastoma multiforme during continuous low-dose chemotherapy with temozolomide and celecoxib

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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