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Child's Nervous System
Published in: Child's Nervous System 1/2014

01-01-2014 | Review Paper

Familial syndromes associated with intracranial tumours: a review

Authors: Adrianna M. Ranger, Yatri K. Patel, Navjot Chaudhary, Ram V. Anantha

Published in: Child's Nervous System | Issue 1/2014

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Abstract

Background

Most cancers of the central nervous system (CNS) occur sporadically in the absence of any known underlying familial disorder or multi-systemic syndrome. Several syndromes are associated with CNS malignancies, however, and their recognition has significant implications for patient management and prognosis. Patients with syndrome-associated CNS malignancies often have multiple tumours (either confined to one region or distributed throughout the body), with similar or different histology.

Objective

This review examines syndromes that are strongly associated with CNS cancers: the phakomatosis syndromes, familial syndromes such as Li–Fraumeni and familial polyposis syndromes and dyschondroplasia.
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Metadata
Title
Familial syndromes associated with intracranial tumours: a review
Authors
Adrianna M. Ranger
Yatri K. Patel
Navjot Chaudhary
Ram V. Anantha
Publication date
01-01-2014
Publisher
Springer Berlin Heidelberg
Published in
Child's Nervous System / Issue 1/2014
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-013-2309-z

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