Skip to main content
Top
Published in: Indian Journal of Surgery 1/2013

01-06-2013 | Case Report

Familial Occurrence of Nonsyndromic Wilms Tumor—A Report in Two Siblings

Authors: Zeenath Begum, Shameem Sharieff, Abdul H. Attar

Published in: Indian Journal of Surgery | Special Issue 1/2013

Login to get access

Abstract

Nephroblastoma, (otherwise known as nephroblastoma) a second most common malignant neoplasm in childhood has been reported in twins, siblings & successive generations. We report two cases of Wilms tumor in female and male siblings first noticed in each at 14 months of age. No congenital anomalies were observed in these patients. Both patients were treated with surgery & histopathology of both the specimens showed a well differentiated Wilms tumor with favourable histology. On follow up both the patients are alive and in complete remission, 4 years after the diagnosis in female & 6 months after the diagnosis in the male sibling.
Literature
1.
go back to reference Birch JM, Breslow NE (1995) Epidemiologic features of Wilms tumor. Hematol Oncol Clin North Am 9(6):1157–1178PubMed Birch JM, Breslow NE (1995) Epidemiologic features of Wilms tumor. Hematol Oncol Clin North Am 9(6):1157–1178PubMed
2.
go back to reference Miller RW, Fraumeni JF, Manning MD (1964) Association of Wilms tumor with aniridia, hemihypertrophy and other congenital malformations. N Eng J Med 270:922–927CrossRef Miller RW, Fraumeni JF, Manning MD (1964) Association of Wilms tumor with aniridia, hemihypertrophy and other congenital malformations. N Eng J Med 270:922–927CrossRef
3.
go back to reference Rapley EA, Barfoot R, Bonaïti-Pellié C, Chompret A, Foulkes W, Perusinghe N et al (1998) Evidence for susceptibility genes to familial Wilms tumour in addition to FWT1 and FWT2. Br J Cancer 83:177–183 Rapley EA, Barfoot R, Bonaïti-Pellié C, Chompret A, Foulkes W, Perusinghe N et al (1998) Evidence for susceptibility genes to familial Wilms tumour in addition to FWT1 and FWT2. Br J Cancer 83:177–183
4.
go back to reference Juberg RC, St Martin EC, Hundley JR (1975) Familial occurrence of Wilms’ tumor: nephroblastoma in one of monozygous twins and in another sibling. Am J Hum Genet 27:155–164PubMedCentralPubMed Juberg RC, St Martin EC, Hundley JR (1975) Familial occurrence of Wilms’ tumor: nephroblastoma in one of monozygous twins and in another sibling. Am J Hum Genet 27:155–164PubMedCentralPubMed
5.
Metadata
Title
Familial Occurrence of Nonsyndromic Wilms Tumor—A Report in Two Siblings
Authors
Zeenath Begum
Shameem Sharieff
Abdul H. Attar
Publication date
01-06-2013
Publisher
Springer India
Published in
Indian Journal of Surgery / Issue Special Issue 1/2013
Print ISSN: 0972-2068
Electronic ISSN: 0973-9793
DOI
https://doi.org/10.1007/s12262-011-0357-8

Other articles of this Special Issue 1/2013

Indian Journal of Surgery 1/2013 Go to the issue