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01-12-2020 | Original Contribution

Familial aggregation analysis of cognitive performance in early-onset bipolar disorder

Authors: Jordi Soler, Sara Lera-Miguel, Luisa Lázaro, Rosa Calvo, Panagiotis Ferentinos, Lourdes Fañanás, Mar Fatjó-Vilas

Published in: European Child & Adolescent Psychiatry | Issue 12/2020

Abstract

We analysed the familial aggregation (familiality) of cognitive dimensions and explored their role as liability markers for early-onset bipolar disorder (EOBD). The sample comprised 99 subjects from 26 families, each with an offspring diagnosed with EOBD. Four cognitive dimensions were assessed: reasoning skills; attention and working memory; memory; and executive functions. Their familiality was investigated in the total sample and in a subset of healthy relatives. The intra-family resemblance score (IRS), a family-based index of the similarity of cognitive performance among family members, was calculated. Familiality was detected for the attention and working memory (AW) dimension in the total sample (ICC = 0.37, p = 0.0004) and in the subsample of healthy relatives (ICC = 0.37, p = 0.016). The IRS reflected that there are families with similar AW mean scores (either high or low) and families with heterogeneous scores. Families with the most common background for the AW dimension (IRS > 0) were selected and dichotomized in two groups according to the mean family AW score. This allowed differentiating families whose members had similar high scores than those with similar low scores: both patients (t = − 4.82, p = 0.0005) and relatives (t = − 5.04, p < 0.0001) of the two groups differed in their AW scores. AW dimension showed familial aggregation, suggesting its putative role as a familial vulnerability marker for EOBD. The IRS estimation allowed the identification of families with homogeneous scores for this dimension. This represents a first step towards the investigation of the underlying mechanisms of AW dimension and the identification of etiological subgroups.

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Title: Familial aggregation analysis of cognitive performance in early-onset bipolar disorder
Authors: Jordi Soler
Sara Lera-Miguel
Luisa Lázaro
Rosa Calvo
Panagiotis Ferentinos
Lourdes Fañanás
Mar Fatjó-Vilas
Publication date: 01-12-2020
Publisher: Springer Berlin Heidelberg
Published in: European Child & Adolescent Psychiatry / Issue 12/2020
Print ISSN: 1018-8827
Electronic ISSN: 1435-165X
DOI: https://doi.org/10.1007/s00787-020-01486-8

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Familial aggregation analysis of cognitive performance in early-onset bipolar disorder

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