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Breast Cancer Research
Published in: Breast Cancer Research 1/2000

01-03-2000 | Meeting abstract

Factors modulating integrin Beta I expression on the breast cancer cell lines MCF-7 and MDA-MB-231

Authors: CJ Pogson, CMW Chan, L-A Martin, GPH Gui, M Dowsett

Published in: Breast Cancer Research | Special Issue 1/2000

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Excerpt

The metastatic cascade describes a sequence of cellular events that forms the pathological basis of tumour progression. The integrins are cell adhesion molecules that play a leading role in this complex process. The objective of this study is to improve our understanding of the role of integrins in breast cancer metastasis by investigating how growth factors (Epidermal Growth Factor (EGF) and Insulin-like Growth Factor 1 (IGF-1)), oestradiol (E2) and tamoxifen affect integrin β I expression. The breast cancer cell lines MCF-7 and MDA-MB-231 were used and integrin expression measured by Western Blotting. …
Metadata
Title
Factors modulating integrin Beta I expression on the breast cancer cell lines MCF-7 and MDA-MB-231
Authors
CJ Pogson
CMW Chan
L-A Martin
GPH Gui
M Dowsett
Publication date
01-03-2000
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue Special Issue 1/2000
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr157

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