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Health and Quality of Life Outcomes
Published in: Health and Quality of Life Outcomes 1/2018

Open Access 01-12-2018 | Short report

Factors influencing health-related quality of life in patients with Type 1 diabetes

Authors: A. J. N. Raymakers, P. Gillespie, M. C. O’Hara, M. D. Griffin, S. F. Dinneen

Published in: Health and Quality of Life Outcomes | Issue 1/2018

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Abstract

Aims

Generic, preference-based measures of health-related quality of life (HRQoL) are a common input to the economic evaluation of new health technologies. As such, it is important to explore what characteristics of patients with Type 1 diabetes might impact scores on such measures.

Methods

This study utilizes baseline data from a cluster-randomized trial that recruited patients with Type 1 diabetes at six centers across Ireland. Health-related quality of life was assessed using the three-level EuroQol EQ-5D (EQ-5D) measure. Patients’ responses to individual dimensions of the EQ-5D were explored. To see which patient factors influenced EQ-5D scores, multivariate regression analysis was conducted with EQ-5D scores as the outcome variable.

Results

Data was available for 437 Type 1 diabetes patients. The median age of these patients was 40 (IQR: 31-49) years and 53.8% were female. Overall, patients reported a high HRQoL based on EQ-5D scores (0.87 (SD: 0.19). Fifty-four percent of patients reported a perfect HRQoL. For those that reported problems, the most common dimension was the anxiety/depression dimension of the EQ-5D (29.6%). In the multivariate regression analysis, self-reported mental illness (− 0.22 (95% CI: -0.34, − 0.10)) and being unemployed (− 0.07 (95% CI: -0.13, − 0.02)) were negatively associated with EQ-5D scores (p < 0.05). The influence of self-reported mental illness was persistent in sensitivity analyses.

Conclusions

The study results indicate that patients with Type 1 diabetes report a high HRQoL based on responses to the EQ-5D. However, there are a substantial number of Type 1 diabetes patients that report problems in the anxiety/depression dimension, which may provide avenues to improve patients’ HRQoL.

Trial registration

Current Controlled Trials ISRCTN79759174.
Appendix
Available only for authorised users
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Metadata
Title
Factors influencing health-related quality of life in patients with Type 1 diabetes
Authors
A. J. N. Raymakers
P. Gillespie
M. C. O’Hara
M. D. Griffin
S. F. Dinneen
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Health and Quality of Life Outcomes / Issue 1/2018
Electronic ISSN: 1477-7525
DOI
https://doi.org/10.1186/s12955-018-0848-4

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