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Open Access 01-12-2021 | Research article

Factors associated with bone health status of Malaysian pre-adolescent children in the PREBONE-Kids Study

Authors: Chung Yuan Chang, Kanimolli Arasu, Soon Yee Wong, Shu Hwa Ong, Wai Yew Yang, Megan Hueh Zan Chong, Meenal Mavinkurve, Erwin Jiayuan Khoo, Karuthan Chinna, Connie Marie Weaver, Winnie Siew Swee Chee

Published in: BMC Pediatrics | Issue 1/2021

Abstract

Background

Modifiable lifestyle factors and body composition can affect the attainment of peak bone mass during childhood. This study performed a cross-sectional analysis of the determinants of bone health among pre-adolescent (N = 243) Malaysian children with habitually low calcium intakes and vitamin D status in Kuala Lumpur (PREBONE-Kids Study).

Methods

Body composition, bone mineral density (BMD), and bone mineral content (BMC) at the lumbar spine (LS) and total body (TB) were assessed using dual-energy X-ray absorptiometry (DXA). Calcium intake was assessed using 1-week diet history, MET (metabolic equivalent of task) score using cPAQ physical activity questionnaire, and serum 25(OH) vitamin D using LC-MS/MS.

Results

The mean calcium intake was 349 ± 180 mg/day and mean serum 25(OH)D level was 43.9 ± 14.5 nmol/L. In boys, lean mass (LM) was a significant predictor of LSBMC (β = 0.539, p < 0.001), LSBMD (β = 0.607, p < 0.001), TBBMC (β = 0.675, p < 0.001) and TBBMD (β = 0.481, p < 0.01). Height was a significant predictor of LSBMC (β = 0.346, p < 0.001) and TBBMC (β = 0.282, p < 0.001) while fat mass (FM) (β = 0.261, p = 0.034) and physical activity measured as MET scores (β = 0.163, p = 0.026) were significant predictors of TBBMD in boys. Among girls, LM was also a significant predictor of LSBMC (β = 0.620, p < 0.001), LSBMD (β = 0.700, p < 0.001), TBBMC (β = 0.542, p < 0.001) and TBBMD (β = 0.747, p < 0.001). Calcium intake was a significant predictor of LSBMC (β = 0.102, p = 0.034), TBBMC (β = 0.122, p < 0.001) and TBBMD (β = 0.196, p = 0.002) in girls.

Conclusions

LM was the major determinant of BMC and BMD among pre-adolescent Malaysian children alongside other modifiable lifestyle factors such as physical activity and calcium intake.

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Title: Factors associated with bone health status of Malaysian pre-adolescent children in the PREBONE-Kids Study
Authors: Chung Yuan Chang
Kanimolli Arasu
Soon Yee Wong
Shu Hwa Ong
Wai Yew Yang
Megan Hueh Zan Chong
Meenal Mavinkurve
Erwin Jiayuan Khoo
Karuthan Chinna
Connie Marie Weaver
Winnie Siew Swee Chee
Publication date: 01-12-2021
Publisher: BioMed Central
Published in: BMC Pediatrics / Issue 1/2021
Electronic ISSN: 1471-2431
DOI: https://doi.org/10.1186/s12887-021-02842-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Factors associated with bone health status of Malaysian pre-adolescent children in the PREBONE-Kids Study

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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