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Published in: BMC Women's Health 1/2018

Open Access 01-12-2018 | Research article

Facing HIV infection and unintended pregnancy: Rakai, Uganda, 2001–2013

Authors: Stephanie Ann Grilo, Xiaoyu Song, Tom Lutalo, Margo Mullinax, Sanyukta Mathur, John Santelli

Published in: BMC Women's Health | Issue 1/2018

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Abstract

Background

Unintended pregnancy is a persistent and global issue with consequences for the health and well-being of mothers and babies. The aim of this paper is to examine unintended pregnancy over time in the context of substantial human immunodeficiency virus (HIV) prevalence and increasing access to anti-retro viral therapy (ART).

Method

Data are from the Rakai Community Cohort Study (RCCS) – a cohort of communities with 10,000–12,000 adults, ages 15–49, in Rakai District, Uganda. We examined prevalence of current pregnancies over time, intended pregnancy, and unintended pregnancies (unwanted, mistimed, ambivalent). We then examined risk factors for the different categories of unintended pregnancy among women who were currently pregnant. The full sample included 32,205 observations over 13 years.

Results

The prevalence of mistimed pregnancy and unwanted pregnancy both decreased significantly over time (p < .001). The prevalence of current pregnancies and intended pregnancy showed no significant changes over the thirteen year period. The same overall pattern was found when only examining HIV positive women in the sample; however, the trends were not significant. Out of the 2820 current pregnancies reported, 54.4% were intended, 29.8% were mistimed, 13.2% were unwanted, and 2.5% were ambivalent. After controlling for other predictors, HIV status had no independent effect on mistimed pregnancy but had a significant effect on unwanted pregnancy (RRR = 2.44, 95% CI = 1.65–3.61, p < .001] and ambivalent pregnancy [RRR = 2.07; CI: 1.03 to 4.18, p = 0.041]. In 2004, after the introduction of ART, there was a decreased risk in unintended pregnancy [RR = 0.75; CI: 0.66 to 0.84, p < .001]. Women with a secondary education or higher also had a decreased risk in unintended pregnancy [RR = 0.70; CI: 0.70 to 0.92, p = 0.002].

Discussion

HIV was an important predictor of unwanted pregnancy. Unintended pregnancy decreased in the sample over time which may be due to an increase in ART availability and rising levels of education.
Literature
1.
go back to reference Singh S, Sedgh G, Hussain R. Unintended pregnancy: worldwide levels, trends, and outcomes. Stud Fam Plan. 2010;41(4):241–50.CrossRef Singh S, Sedgh G, Hussain R. Unintended pregnancy: worldwide levels, trends, and outcomes. Stud Fam Plan. 2010;41(4):241–50.CrossRef
2.
go back to reference Brown SS, Eisenberg, L. (Eds.). The best intentions: unintended pregnancy and the well-being of children and families: National Academies Press; 1995. Brown SS, Eisenberg, L. (Eds.). The best intentions: unintended pregnancy and the well-being of children and families: National Academies Press; 1995.
3.
go back to reference Sedgh G, Singh S, Hussain R. Intended and unintended pregnancies worldwide in 2012 and recent trends. Stud Fam Plan. 2014;45(3):301–14.CrossRef Sedgh G, Singh S, Hussain R. Intended and unintended pregnancies worldwide in 2012 and recent trends. Stud Fam Plan. 2014;45(3):301–14.CrossRef
5.
go back to reference Gipson JD, Koenig MA, Hindin MJ. The effects of unintended pregnancy on infant, child, and parental health: a review of the literature. Stud Fam Plan. 2008;39(1):18–38.CrossRef Gipson JD, Koenig MA, Hindin MJ. The effects of unintended pregnancy on infant, child, and parental health: a review of the literature. Stud Fam Plan. 2008;39(1):18–38.CrossRef
7.
go back to reference Santelli J, Rochat R, Hatfield-Timajchy K, Gilbert BC, Curtis K, Cabral R, et al. The measurement and meaning of unintended pregnancy. Perspect Sex Reprod Health. 2003;35(2):94–101.CrossRefPubMed Santelli J, Rochat R, Hatfield-Timajchy K, Gilbert BC, Curtis K, Cabral R, et al. The measurement and meaning of unintended pregnancy. Perspect Sex Reprod Health. 2003;35(2):94–101.CrossRefPubMed
8.
go back to reference Prada E, Atuyambe LM, Blades NM, Bukenya JN, Orach CG, Bankole A. Incidence of induced abortion in Uganda, 2013: new estimates since 2003. PLoS One. 2016;11(11):e0165812.CrossRefPubMedPubMedCentral Prada E, Atuyambe LM, Blades NM, Bukenya JN, Orach CG, Bankole A. Incidence of induced abortion in Uganda, 2013: new estimates since 2003. PLoS One. 2016;11(11):e0165812.CrossRefPubMedPubMedCentral
9.
go back to reference Nakayiwa S, Abang B, Packel L, Lifshay J, Purcell DW, King R, et al. Desire for children and pregnancy risk behavior among HIV-infected men and women in Uganda. AIDS Behav. 2006;10(1):95–104.CrossRef Nakayiwa S, Abang B, Packel L, Lifshay J, Purcell DW, King R, et al. Desire for children and pregnancy risk behavior among HIV-infected men and women in Uganda. AIDS Behav. 2006;10(1):95–104.CrossRef
10.
go back to reference Kaida A, Lima VD, Andia I, Kabakyenga J, Mbabazi P, Emenyonu N, et al. The WHOMEN’s Scale (Women’s HAART Optimism Monitoring and EvaluatioN Scale v. 1) and the association with fertility intentions and sexual behaviours among HIV-positive women in Uganda. AIDS and Behavior. 2009;13(1):72–81. Kaida A, Lima VD, Andia I, Kabakyenga J, Mbabazi P, Emenyonu N, et al. The WHOMEN’s Scale (Women’s HAART Optimism Monitoring and EvaluatioN Scale v. 1) and the association with fertility intentions and sexual behaviours among HIV-positive women in Uganda. AIDS and Behavior. 2009;13(1):72–81.
11.
go back to reference Kanniappan SJM.J, Jeyapaul MJ, & Kalyanwala S. Desire for motherhood: exploring HIV-positive women's desires, intentions and decision-making in attaining motherhood. AIDS care. 2008;20(6):625–630. Kanniappan SJM.J, Jeyapaul MJ, & Kalyanwala S. Desire for motherhood: exploring HIV-positive women's desires, intentions and decision-making in attaining motherhood. AIDS care. 2008;20(6):625–630.
12.
go back to reference Maier M, Andia I, Emenyonu N, Guzman D, Kaida A, Pepper L, et al. Antiretroviral therapy is associated with increased fertility desire, but not pregnancy or live birth, among HIV+ women in an early HIV treatment program in rural Uganda. AIDS Behav. 2009;13(1):28–37.CrossRefPubMed Maier M, Andia I, Emenyonu N, Guzman D, Kaida A, Pepper L, et al. Antiretroviral therapy is associated with increased fertility desire, but not pregnancy or live birth, among HIV+ women in an early HIV treatment program in rural Uganda. AIDS Behav. 2009;13(1):28–37.CrossRefPubMed
13.
go back to reference King R, Khana K, Nakayiwa S, Katuntu D, Homsy J, Lindkvist P, et al. 'Pregnancy comes accidentally-like it did with me': reproductive decisions among women on ART and their partners in rural Uganda. BMC Public Health. 2011;11(1):1.CrossRef King R, Khana K, Nakayiwa S, Katuntu D, Homsy J, Lindkvist P, et al. 'Pregnancy comes accidentally-like it did with me': reproductive decisions among women on ART and their partners in rural Uganda. BMC Public Health. 2011;11(1):1.CrossRef
14.
go back to reference Mathur, S. (2014, November). Shifting Desires for Children within the Context of HIV/AIDS in Rakai, Uganda from 2001-2011. In 142nd APHA Annual Meeting and Exposition (November 15–November 19, 2014). APHA. Mathur, S. (2014, November). Shifting Desires for Children within the Context of HIV/AIDS in Rakai, Uganda from 2001-2011. In 142nd APHA Annual Meeting and Exposition (November 15–November 19, 2014). APHA.
15.
go back to reference Sewankambo NK, Wawer MJ, Gray RH, Serwadda D, Li C, Stallings RY, et al. Demographic impact of HIV infection in rural Rakai district, Uganda: results of a population-based cohort study. AIDS. 1994;8(12):1707–14.CrossRefPubMed Sewankambo NK, Wawer MJ, Gray RH, Serwadda D, Li C, Stallings RY, et al. Demographic impact of HIV infection in rural Rakai district, Uganda: results of a population-based cohort study. AIDS. 1994;8(12):1707–14.CrossRefPubMed
16.
go back to reference Kagulire SC, et al. Field evaluation of five rapid diagnostic tests for screening of HIV-1 infections in rural Rakai, Uganda. Int J STD AIDS. 2011;22(6):308–9.CrossRefPubMedPubMedCentral Kagulire SC, et al. Field evaluation of five rapid diagnostic tests for screening of HIV-1 infections in rural Rakai, Uganda. Int J STD AIDS. 2011;22(6):308–9.CrossRefPubMedPubMedCentral
18.
go back to reference Makumbi FE, Nakigozi G, Reynolds SJ, Ndyanabo A, Lutalo T, Serwada D, Gray R. Associations between HIV antiretroviral therapy and the prevalence and incidence of pregnancy in Rakai, Uganda. AIDS research and treatment. 2011;2011 Makumbi FE, Nakigozi G, Reynolds SJ, Ndyanabo A, Lutalo T, Serwada D, Gray R. Associations between HIV antiretroviral therapy and the prevalence and incidence of pregnancy in Rakai, Uganda. AIDS research and treatment. 2011;2011
19.
go back to reference Santelli JS, Edelstein ZR, Mathur S, Wei Y, Zhang W, Orr MG, et al. Behavioral, biological, and demographic risk and protective factors for new HIV infections among youth, Rakai, Uganda. J Acquir Immune Defic Syndr. 2013;(1999):63(3). 393 Santelli JS, Edelstein ZR, Mathur S, Wei Y, Zhang W, Orr MG, et al. Behavioral, biological, and demographic risk and protective factors for new HIV infections among youth, Rakai, Uganda. J Acquir Immune Defic Syndr. 2013;(1999):63(3). 393
20.
go back to reference Lutalo T, Kigozi G, Kimera E, Serwadda D, Wawer MJ, Zabin LS, Gray RH. A randomized community trial of enhanced family planning outreach in Rakai, Uganda. Stud Fam Plan. 2010;41(1):55–60.CrossRef Lutalo T, Kigozi G, Kimera E, Serwadda D, Wawer MJ, Zabin LS, Gray RH. A randomized community trial of enhanced family planning outreach in Rakai, Uganda. Stud Fam Plan. 2010;41(1):55–60.CrossRef
21.
go back to reference Gray RH, Wawer MJ, Serwadda D, et al. Population-based study of fertility in women with HIV-1 infection in Uganda. Lancet. 1998;351(9096):98–103.CrossRefPubMed Gray RH, Wawer MJ, Serwadda D, et al. Population-based study of fertility in women with HIV-1 infection in Uganda. Lancet. 1998;351(9096):98–103.CrossRefPubMed
22.
go back to reference Nguyen RHN, Gange SJ, Wabwire-Mangen F, et al. Reduced fertility among HIV-infected women associated with viral load in Rakai district, Uganda. Int J STD AIDS. Dec 2006;17(12):842–6.CrossRefPubMed Nguyen RHN, Gange SJ, Wabwire-Mangen F, et al. Reduced fertility among HIV-infected women associated with viral load in Rakai district, Uganda. Int J STD AIDS. Dec 2006;17(12):842–6.CrossRefPubMed
23.
go back to reference Cooper D, Harries J, Myer L, Orner P, Bracken H. “Life is still going on”: reproductive intentions among HIV-positive women and men in South Africa. Soc Sci Med. 2007;65(2):274–83.CrossRefPubMed Cooper D, Harries J, Myer L, Orner P, Bracken H. “Life is still going on”: reproductive intentions among HIV-positive women and men in South Africa. Soc Sci Med. 2007;65(2):274–83.CrossRefPubMed
24.
go back to reference Kasamba I, Baisley K, Mayanja BN, Maher D, Grosskurth H. The impact of antiretroviral treatment on mortality trends of HIV-positive adults in rural Uganda: a longitudinal population-based study, 1999–2009. Tropical Med Int Health. 2012;17(8):e66-e73.CrossRef Kasamba I, Baisley K, Mayanja BN, Maher D, Grosskurth H. The impact of antiretroviral treatment on mortality trends of HIV-positive adults in rural Uganda: a longitudinal population-based study, 1999–2009. Tropical Med Int Health. 2012;17(8):e66-e73.CrossRef
26.
go back to reference Deininger K. Does cost of schooling affect enrollment by the poor? Universal primary education in Uganda. Econ Educ Rev. 2003;22(3):291–305.CrossRef Deininger K. Does cost of schooling affect enrollment by the poor? Universal primary education in Uganda. Econ Educ Rev. 2003;22(3):291–305.CrossRef
27.
go back to reference Santelli JS, Mathur S, Song X, Huang TJ, Wei Y, Lutalo T, et al. Rising school enrollment and declining HIV and pregnancy risk among adolescents in Rakai District, Uganda, 1994–2013. Global Social Welfare. 2015;2(2):87–103.CrossRefPubMedPubMedCentral Santelli JS, Mathur S, Song X, Huang TJ, Wei Y, Lutalo T, et al. Rising school enrollment and declining HIV and pregnancy risk among adolescents in Rakai District, Uganda, 1994–2013. Global Social Welfare. 2015;2(2):87–103.CrossRefPubMedPubMedCentral
28.
go back to reference Lloyd CB. Growing up global: the changing transitions to adulthood in developing countries. National: Academic Press; 2005. Lloyd CB. Growing up global: the changing transitions to adulthood in developing countries. National: Academic Press; 2005.
29.
go back to reference Grimes DA, Benson J, Singh S, Romero M, Ganatra B, Okonofua FE, Shah IH. Unsafe abortion: the preventable pandemic. Lancet. 2006;368(9550):1908–19.CrossRefPubMed Grimes DA, Benson J, Singh S, Romero M, Ganatra B, Okonofua FE, Shah IH. Unsafe abortion: the preventable pandemic. Lancet. 2006;368(9550):1908–19.CrossRefPubMed
Metadata
Title
Facing HIV infection and unintended pregnancy: Rakai, Uganda, 2001–2013
Authors
Stephanie Ann Grilo
Xiaoyu Song
Tom Lutalo
Margo Mullinax
Sanyukta Mathur
John Santelli
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Women's Health / Issue 1/2018
Electronic ISSN: 1472-6874
DOI
https://doi.org/10.1186/s12905-018-0535-y

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