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Open Access 01-09-2015 | Original Article

Extrastriate projections in human optic radiation revealed by fMRI-informed tractography

Authors: Ivan Alvarez, D. Samuel Schwarzkopf, Chris A. Clark

Published in: Brain Structure and Function | Issue 5/2015

Abstract

The human optic radiation (OR) is the main pathway for conveying visual input to occipital cortex, but it is unclear whether it projects beyond primary visual cortex (V1). In this study, we used functional MRI mapping to delineate early visual areas in 30 healthy volunteers and determined the termination area of the OR as reconstructed with diffusion tractography. Direct thalamo-cortical projections to areas V2 and V3 were found in all hemispheres tested, with a distinct anatomical arrangement of superior–inferior fiber placement for dorsal and ventral projections, respectively, and a medio-lateral nesting arrangement for projections to V1, V2 and V3. Finally, segment-specific microstructure was examined, revealing sub-fascicular information. This is to date the first in vivo demonstration of direct extrastriate projections of the OR in humans.

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Title: Extrastriate projections in human optic radiation revealed by fMRI-informed tractography
Authors: Ivan Alvarez
D. Samuel Schwarzkopf
Chris A. Clark
Publication date: 01-09-2015
Publisher: Springer Berlin Heidelberg
Published in: Brain Structure and Function / Issue 5/2015
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-014-0799-4

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Extrastriate projections in human optic radiation revealed by fMRI-informed tractography

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