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01-11-2008 | Hepatobiliary and Pancreatic Tumors

Extrapancreatic Malignancies in Patients with Intraductal Papillary Mucinous Neoplasm of the Pancreas: Prevalence, Associated Factors, and Comparison with Patients with Other Pancreatic Cystic Neoplasms

Authors: Won Jae Yoon, MD, Ji Kon Ryu, MD, Jun Kyu Lee, MD, Sang Myung Woo, MD, Sang Hyub Lee, MD, Joo Kyung Park, MD, Yong-Tae Kim, MD, Yong Bum Yoon, MD

Published in: Annals of Surgical Oncology | Issue 11/2008

Abstract

Background

Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is reported to have a high prevalence of extrapancreatic malignancy (EPM). The aims of this study were to evaluate the prevalence and associated factors of EPMs in IPMN patients and to compare these data with those of non-IPMN pancreatic cystic neoplasm (PCN) patients.

Methods

The study included 385 PCN patients (210 IPMNs and 175 non-IPMNs) diagnosed from 1993 to 2007. PCN types, presence of EPMs, chronological relation of EPMs to PCN diagnosis, and their clinicopathological parameters were analyzed.

Results

The prevalence of EPM was 33.8% for IPMNs and 12.0% for non-IPMN PCNs (P < 0.001). In the majority of patients with EPMs, PCNs were detected while undergoing workup for the EPMs. For IPMNs, age was associated with EPMs [odds ratio (OR) 1.05, P = 0.013]; malignant IPMN showed a borderline inverse association with EPMs (OR 0.50, P = 0.071). Multivariate analysis of entire PCN cohort demonstrated that age at PCN diagnosis (OR 1.05, P < 0.001) was positively associated with EPM; IPMN showed a borderline positive association with EPM (OR 1.88, P = 0.052). Malignant PCN (OR 0.40, P = 0.009) was inversely associated with EPM.

Conclusion

The EPM prevalence of IPMN patients was 33.8%. Advanced age at IPMN diagnosis was the only factor significantly associated with EPMs in our IPMN cohort. In our PCN cohort, advanced age at PCN diagnosis was associated with malignant PCN and IPMN showed a borderline positive association with EPM.

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Title: Extrapancreatic Malignancies in Patients with Intraductal Papillary Mucinous Neoplasm of the Pancreas: Prevalence, Associated Factors, and Comparison with Patients with Other Pancreatic Cystic Neoplasms
Authors: Won Jae Yoon, MD
Ji Kon Ryu, MD
Jun Kyu Lee, MD
Sang Myung Woo, MD
Sang Hyub Lee, MD
Joo Kyung Park, MD
Yong-Tae Kim, MD
Yong Bum Yoon, MD
Publication date: 01-11-2008
Publisher: Springer-Verlag
Published in: Annals of Surgical Oncology / Issue 11/2008
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-008-0143-4

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Extrapancreatic Malignancies in Patients with Intraductal Papillary Mucinous Neoplasm of the Pancreas: Prevalence, Associated Factors, and Comparison with Patients with Other Pancreatic Cystic Neoplasms

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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