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Published in: Head and Neck Pathology 2/2014

01-06-2014 | Case Report

Extramedullary Plasmacytoma of the Trachea

Authors: Renu Sukumaran, Rekha A. Nair, Priya Mary Jacob, Sumod Mathew Koshy, Arun Peter Mathew

Published in: Head and Neck Pathology | Issue 2/2014

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Abstract

Extramedullary plasmacytomas are plasma cell tumors that occur outside the bone marrow. They constitute around 4 % of all plasma cell neoplasms. The most common site of extramedullary plasmacytoma is the upper aerodigestive tract—nasal cavity, paranasal sinuses and oronasopharynx. We are presenting a case of extramedullary plasmacytoma of the trachea. Trachea is an extremely rare site of plasmacytoma. When extraosseous plasmacytoma occur in uncommon sites, the distinction from B cell lymphomas showing extensive plasmacytic differentiation can be difficult and diagnostically challenging.
Literature
1.
go back to reference Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW, editors. WHO classification of tumors of haematopoetic and lymphoid tissues. IARC: Lyon, France; 2008. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW, editors. WHO classification of tumors of haematopoetic and lymphoid tissues. IARC: Lyon, France; 2008.
2.
go back to reference Bachar G, Goldstein D, Brown D, Tsang R, Lockwood G, Perez-Ordonez B, Irish J. Solitary extramedullary plasmacytoma of the head and neck-long term outcome analysis of 68 cases. Head Neck. 2008;30:1012–9.PubMedCrossRef Bachar G, Goldstein D, Brown D, Tsang R, Lockwood G, Perez-Ordonez B, Irish J. Solitary extramedullary plasmacytoma of the head and neck-long term outcome analysis of 68 cases. Head Neck. 2008;30:1012–9.PubMedCrossRef
3.
go back to reference Reyhan M, Rercan F, Ergin M, Sukan A, Aydin M, Yapar F. Sonographic diagnosis of a tracheal extramedullary plasmacytoma. J Ultrasound Med. 2005;24:1031–4.PubMed Reyhan M, Rercan F, Ergin M, Sukan A, Aydin M, Yapar F. Sonographic diagnosis of a tracheal extramedullary plasmacytoma. J Ultrasound Med. 2005;24:1031–4.PubMed
4.
go back to reference Papadopoulou A, Froudarakis M, Abatzoglou I, Koukourakis MI. Tracheal cancer treated with a short course of external and endoluminal radio-chemotherapy combined with cetuximab—a case report. J Contemp Brachyther. 2010;2:160–2.CrossRef Papadopoulou A, Froudarakis M, Abatzoglou I, Koukourakis MI. Tracheal cancer treated with a short course of external and endoluminal radio-chemotherapy combined with cetuximab—a case report. J Contemp Brachyther. 2010;2:160–2.CrossRef
5.
go back to reference Rai SP, Kumar R, Bharadwaj R, Panda BN. Solitary tracheal plasmacytoma. Indian J Chest Dis Allied Sci. 2003;45:269–72.PubMed Rai SP, Kumar R, Bharadwaj R, Panda BN. Solitary tracheal plasmacytoma. Indian J Chest Dis Allied Sci. 2003;45:269–72.PubMed
6.
go back to reference Lomeo PE, McDonald JE, Finneman J. Shoreline. Extramedullary plasmacytoma of nasal sinus cavities. Am J Otolaryngol. 2007;28:50–1.PubMedCrossRef Lomeo PE, McDonald JE, Finneman J. Shoreline. Extramedullary plasmacytoma of nasal sinus cavities. Am J Otolaryngol. 2007;28:50–1.PubMedCrossRef
7.
go back to reference Seegmiller AC, Xu Y, McKenna RW, Karandikar NJ. Immunophenotypic differentiation between neoplastic plasma cells in mature B cell lymphoma vs plasma cell myeloma. Am J Clin Pathol. 2007;127:176–81.PubMedCrossRef Seegmiller AC, Xu Y, McKenna RW, Karandikar NJ. Immunophenotypic differentiation between neoplastic plasma cells in mature B cell lymphoma vs plasma cell myeloma. Am J Clin Pathol. 2007;127:176–81.PubMedCrossRef
8.
go back to reference Ely SA, Knowles DM. Expression of CD56/neural cell adhesion molecule correlates with the presence of lytic bone lesions in multiple myeloma and distinguishes myeloma from monoclonal gammopathy of undetermined significance and lymphomas with plasmacytoid differentiation. Am J Pathol. 2002;160:1293–9.PubMedCentralPubMedCrossRef Ely SA, Knowles DM. Expression of CD56/neural cell adhesion molecule correlates with the presence of lytic bone lesions in multiple myeloma and distinguishes myeloma from monoclonal gammopathy of undetermined significance and lymphomas with plasmacytoid differentiation. Am J Pathol. 2002;160:1293–9.PubMedCentralPubMedCrossRef
9.
go back to reference Van Camp B, Durie BG, Spier C, De Waele M, Van Riet I, Vela E, et al. Plasma cells in multiple myeloma express a natural killer cell-associated antigen:cD56 (NKH_1;Leu-19). Blood. 1990;76:377–82.PubMed Van Camp B, Durie BG, Spier C, De Waele M, Van Riet I, Vela E, et al. Plasma cells in multiple myeloma express a natural killer cell-associated antigen:cD56 (NKH_1;Leu-19). Blood. 1990;76:377–82.PubMed
10.
go back to reference Kremer M, Ott G, Nathrath M, Specht K, Stecker K, Alexiou C, et al. Primary extramedullary plasmacytoma and multiple myeloma: phenotypic differences revealed by immunohistochemical analysis. J Pathol. 2005;205:92–101.PubMedCrossRef Kremer M, Ott G, Nathrath M, Specht K, Stecker K, Alexiou C, et al. Primary extramedullary plasmacytoma and multiple myeloma: phenotypic differences revealed by immunohistochemical analysis. J Pathol. 2005;205:92–101.PubMedCrossRef
11.
go back to reference Hussong JW, Perkins SL, Schnitzer B, Hargreaves H, Frizzera G. Extramedullary plasmacytoma : a form of marginal zone lymphoma ? Am J Clin Pathol. 1999;111:111–6.PubMed Hussong JW, Perkins SL, Schnitzer B, Hargreaves H, Frizzera G. Extramedullary plasmacytoma : a form of marginal zone lymphoma ? Am J Clin Pathol. 1999;111:111–6.PubMed
12.
go back to reference Bink K, Haralambieva E, Kremer M, Ott G, Beham-Schmid C, de Leval L, et al. Primary extramedullary plasmacytoma: similarities with and differences from multiple myeloma revealed by interphase cytogenetics. Heamatologica. 2008;93:623–6.CrossRef Bink K, Haralambieva E, Kremer M, Ott G, Beham-Schmid C, de Leval L, et al. Primary extramedullary plasmacytoma: similarities with and differences from multiple myeloma revealed by interphase cytogenetics. Heamatologica. 2008;93:623–6.CrossRef
13.
go back to reference Dimopoulos MA, Hamilos G. Solitary bone plasmacytoma and extramedullary plasmacytoma. Curr Treat Options Oncol. 2002;3:255–9.PubMedCrossRef Dimopoulos MA, Hamilos G. Solitary bone plasmacytoma and extramedullary plasmacytoma. Curr Treat Options Oncol. 2002;3:255–9.PubMedCrossRef
14.
go back to reference Alexiou C, Kau RJ, Dietzfelbinger H, Kremer M, Spiess JC, Schratzenstaller B, et al. Extramedullary plasmacytoma: tumor occurrence and therapeutic concepts. Cancer. 1999;85:2305–14.PubMedCrossRef Alexiou C, Kau RJ, Dietzfelbinger H, Kremer M, Spiess JC, Schratzenstaller B, et al. Extramedullary plasmacytoma: tumor occurrence and therapeutic concepts. Cancer. 1999;85:2305–14.PubMedCrossRef
Metadata
Title
Extramedullary Plasmacytoma of the Trachea
Authors
Renu Sukumaran
Rekha A. Nair
Priya Mary Jacob
Sumod Mathew Koshy
Arun Peter Mathew
Publication date
01-06-2014
Publisher
Springer US
Published in
Head and Neck Pathology / Issue 2/2014
Electronic ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-013-0491-7

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