Skip to main content
Top
Published in: General Thoracic and Cardiovascular Surgery 3/2018

01-03-2018 | Current Topics Review Article

Extracorporeal lung support for advanced lung failure: a new era in thoracic surgery and translational science

Author: Norihisa Shigemura

Published in: General Thoracic and Cardiovascular Surgery | Issue 3/2018

Login to get access

Abstract

For the patients with progressively decompensating acute or acute-on-chronic respiratory failure, the first-choice treatment remains as mechanical ventilation. Despite the consistent value of mechanical ventilation, the majority of lung specialists are aware of its limitations, in particular for the patients with advanced lung failure, and inherent drawbacks that augment disease progression. More recently, the concept of allowing the lungs to ‘rest and recover’ has been supported by quite a few clinical studies. The pressure and volume of gas delivered to the lungs are reduced compared with mechanical ventilation. Based on recent remarkable evidence and experiences using extracorporeal lung support (ECLS) before, during and after lung transplant, there is growing interest in and expectations for the use of ECLS beyond lung transplant to encompass the entire field of pulmonary medicine. The purpose of this review article is to provide an update on evolving ECLS technologies and their effectiveness and discuss the future of ECLS for advanced lung failure as a new subspecialty in cardiothoracic surgery.
Literature
1.
go back to reference Van Raemdonck D, Neyrinck A, Cypel M, Keshavjee S. Ex-vivo lung perfusion. Transplant Int. 2015;28:643–56.CrossRef Van Raemdonck D, Neyrinck A, Cypel M, Keshavjee S. Ex-vivo lung perfusion. Transplant Int. 2015;28:643–56.CrossRef
2.
go back to reference Cypel M, Yeung JC, Liu M, et al. Normothermic ex vivo lung perfusion in clinical lung transplantation. N Engl J Med. 2011;364:1431–40.CrossRefPubMed Cypel M, Yeung JC, Liu M, et al. Normothermic ex vivo lung perfusion in clinical lung transplantation. N Engl J Med. 2011;364:1431–40.CrossRefPubMed
3.
go back to reference Tane S, Noda K, Shigemura N. Ex vivo lung perfusion: A key tool for translational science in the lungs. Chest. 2017;151:1220–8.CrossRefPubMed Tane S, Noda K, Shigemura N. Ex vivo lung perfusion: A key tool for translational science in the lungs. Chest. 2017;151:1220–8.CrossRefPubMed
4.
go back to reference Toyoda Y, Bhama JK, Shigemura N, et al. Efficacy of extracorporeal membrane oxygenation as a bridge to lung transplantation. J Thorac Cardiovasc Surg. 2013;145:1065–70.CrossRefPubMed Toyoda Y, Bhama JK, Shigemura N, et al. Efficacy of extracorporeal membrane oxygenation as a bridge to lung transplantation. J Thorac Cardiovasc Surg. 2013;145:1065–70.CrossRefPubMed
5.
go back to reference Bermudez CA, Shiose A, Esper SA, et al. Outcomes of intraoperative venoarterial extracorporeal membrane oxygenation versus cardiopulmonary bypass during lung transplantation. Ann Thorac Surg. 2014;98:1936–42.CrossRefPubMed Bermudez CA, Shiose A, Esper SA, et al. Outcomes of intraoperative venoarterial extracorporeal membrane oxygenation versus cardiopulmonary bypass during lung transplantation. Ann Thorac Surg. 2014;98:1936–42.CrossRefPubMed
6.
go back to reference Mulvihill MS, Yerokun BA, Davis RP, et al. Extracorporeal membrane oxygenation following lung transplantation: indications and survival. J Heart Lung Transplant 2017 (Epub ahead of print). Mulvihill MS, Yerokun BA, Davis RP, et al. Extracorporeal membrane oxygenation following lung transplantation: indications and survival. J Heart Lung Transplant 2017 (Epub ahead of print).
7.
go back to reference Valapour M, Skeans MA, Smith JM, et al. OPTN/SRTR 2015 Annual Data Report: Lung. Am J Transplant. 2017 (Epub ahead of print). Valapour M, Skeans MA, Smith JM, et al. OPTN/SRTR 2015 Annual Data Report: Lung. Am J Transplant. 2017 (Epub ahead of print).
8.
go back to reference Mason DP, Thuita L, Nowicki ER, et al. Should lung transplantation be performed for patients on mechanical respiratory support? The US experience. J Thorac Cardiovasc Surg. 2010;139:765–73.CrossRefPubMed Mason DP, Thuita L, Nowicki ER, et al. Should lung transplantation be performed for patients on mechanical respiratory support? The US experience. J Thorac Cardiovasc Surg. 2010;139:765–73.CrossRefPubMed
9.
go back to reference Hayes DJ, Tobias JD, Tumin D. Center volume and extracorporeal membrane oxygenation support at lung transplantation in the lung allocation score era. Am J Respir Crit Care Med. 2016;194:317–26.CrossRefPubMed Hayes DJ, Tobias JD, Tumin D. Center volume and extracorporeal membrane oxygenation support at lung transplantation in the lung allocation score era. Am J Respir Crit Care Med. 2016;194:317–26.CrossRefPubMed
10.
go back to reference Hayanga AJ, Du AL, Joubert K, et al. Mechanical ventilation and extracorporeal membrane oxygenation as a bridging strategy to lung transplantation: Significant gains in survival. Am J Transplant 2017 [Epub ahead of print]. Hayanga AJ, Du AL, Joubert K, et al. Mechanical ventilation and extracorporeal membrane oxygenation as a bridging strategy to lung transplantation: Significant gains in survival. Am J Transplant 2017 [Epub ahead of print].
11.
go back to reference Tong MZ. Con: extracorporeal membrane oxygenation should not routinely replace cardiopulmonary bypass as the preferred method of support during lung transplantation. J Cardiothorac Vasc Anesth. 2017;31:1509–10.CrossRefPubMed Tong MZ. Con: extracorporeal membrane oxygenation should not routinely replace cardiopulmonary bypass as the preferred method of support during lung transplantation. J Cardiothorac Vasc Anesth. 2017;31:1509–10.CrossRefPubMed
12.
go back to reference Machuca TN, Collaud S, Mercier O, et al. Outcomes of intraoperative extracorporeal membrane oxygenation versus cardiopulmonary bypass for lung transplantation. J Thorac Cardiovasc Surg. 2015;149:1152–7.CrossRefPubMed Machuca TN, Collaud S, Mercier O, et al. Outcomes of intraoperative extracorporeal membrane oxygenation versus cardiopulmonary bypass for lung transplantation. J Thorac Cardiovasc Surg. 2015;149:1152–7.CrossRefPubMed
13.
go back to reference Biscottti M, Yang J, Sonett J, et al. Comparison of extracorporeal membrane oxygenation versus cardiopulmonary bypass for lung transplantation. J Thorac Cardiovasc Surg. 2014;148:2410–5.CrossRef Biscottti M, Yang J, Sonett J, et al. Comparison of extracorporeal membrane oxygenation versus cardiopulmonary bypass for lung transplantation. J Thorac Cardiovasc Surg. 2014;148:2410–5.CrossRef
14.
go back to reference Fischer S, Bohn D, Rycus P, et al. Extracorporeal membrane oxygenation for primary graft dysfunction after lung transplantation: analysis of the Extracorporeal Life Support Organization (ELSO) registry. J Heart Lung Transplant. 2007;26:472–7.CrossRefPubMed Fischer S, Bohn D, Rycus P, et al. Extracorporeal membrane oxygenation for primary graft dysfunction after lung transplantation: analysis of the Extracorporeal Life Support Organization (ELSO) registry. J Heart Lung Transplant. 2007;26:472–7.CrossRefPubMed
15.
go back to reference Hartwig MG, Walczak R, Lin SS, et al. Improved survival but marginal allograft function in patients treated with extracorporeal membrane oxygenation after lung transplantation. Ann Thorac Surg. 2012;93:366–71.CrossRefPubMed Hartwig MG, Walczak R, Lin SS, et al. Improved survival but marginal allograft function in patients treated with extracorporeal membrane oxygenation after lung transplantation. Ann Thorac Surg. 2012;93:366–71.CrossRefPubMed
16.
go back to reference Morelli A, Sorbo LD, Pesenti A, Ranieri M, Fan E. Extracorporeal carbon dioxide removal (ECCO2R) in patients with acute respiratory failure. Intensive Care Med 2017; 43: 519–30.CrossRefPubMed Morelli A, Sorbo LD, Pesenti A, Ranieri M, Fan E. Extracorporeal carbon dioxide removal (ECCO2R) in patients with acute respiratory failure. Intensive Care Med 2017; 43: 519–30.CrossRefPubMed
17.
go back to reference Kluge S, Braune SA, Engel M, Nierhaus A, Frings D, Ebelt H, Uhrig A, Metschke M, Wegscheider K, Suttorp N. Simone Rousseau. Avoiding invasive mechanical ventilation by extracorporeal carbon dioxide removal in patients failing noninvasive ventilation. Intensive Care Med 2012; 38: 1632–9.CrossRefPubMed Kluge S, Braune SA, Engel M, Nierhaus A, Frings D, Ebelt H, Uhrig A, Metschke M, Wegscheider K, Suttorp N. Simone Rousseau. Avoiding invasive mechanical ventilation by extracorporeal carbon dioxide removal in patients failing noninvasive ventilation. Intensive Care Med 2012; 38: 1632–9.CrossRefPubMed
18.
go back to reference Fischer S, Simon AR, Welte T, Hoeper MM, Meyer A, Tessmann R, Gohrbandt B, Gottlieb J, Haverich A, Strueber M. Bridge to lung transplantation with the novel pumpless interventional lung assist device NovaLung. J Thorac Cardiovasc Surg 2006; 131: 719–23.CrossRefPubMed Fischer S, Simon AR, Welte T, Hoeper MM, Meyer A, Tessmann R, Gohrbandt B, Gottlieb J, Haverich A, Strueber M. Bridge to lung transplantation with the novel pumpless interventional lung assist device NovaLung. J Thorac Cardiovasc Surg 2006; 131: 719–23.CrossRefPubMed
19.
go back to reference Bartosik W, Egan JJ, Wood AE. The Novalung interventional lung assist as bridge to lung transplantation for self-ventilating patients – initial experience. Interact CardioVasc Thorac Surg. 2011;13:198–200.CrossRefPubMed Bartosik W, Egan JJ, Wood AE. The Novalung interventional lung assist as bridge to lung transplantation for self-ventilating patients – initial experience. Interact CardioVasc Thorac Surg. 2011;13:198–200.CrossRefPubMed
20.
go back to reference Wearden PD, Federspiel WJ, Morley SW, Rosenberg M, Bieniek PD, Lund LW, Ochs BD. Respiratory dialysis with an active-mixing extracorporeal carbon dioxide removal system in a chronic sheep study. Intensive Care Med. 2012;38:1705–11.CrossRefPubMedPubMedCentral Wearden PD, Federspiel WJ, Morley SW, Rosenberg M, Bieniek PD, Lund LW, Ochs BD. Respiratory dialysis with an active-mixing extracorporeal carbon dioxide removal system in a chronic sheep study. Intensive Care Med. 2012;38:1705–11.CrossRefPubMedPubMedCentral
21.
go back to reference Cove ME, MacLaren G, Federspiel WJ, Kellum JA. Bench to bedside review: Extracorporeal carbon dioxide removal, past present and future. Crit Care. 2012;16:232.CrossRefPubMedPubMedCentral Cove ME, MacLaren G, Federspiel WJ, Kellum JA. Bench to bedside review: Extracorporeal carbon dioxide removal, past present and future. Crit Care. 2012;16:232.CrossRefPubMedPubMedCentral
22.
go back to reference Burki NK, Mani RK, Herth FJF, Schmidt W, Teschler H, Bonin F, Becker H, Randerath WJ, Stieglitz S, Hagmeyer L, Priegnitz C, Pfeifer M, Quintel M, Moerer O. A novel extracorporeal CO2 removal system. Chest 2013; 143: 678–86.CrossRefPubMed Burki NK, Mani RK, Herth FJF, Schmidt W, Teschler H, Bonin F, Becker H, Randerath WJ, Stieglitz S, Hagmeyer L, Priegnitz C, Pfeifer M, Quintel M, Moerer O. A novel extracorporeal CO2 removal system. Chest 2013; 143: 678–86.CrossRefPubMed
23.
24.
go back to reference Jirsch DW, Fisk RL, Couves CM. Ex vivo evaluation of stored lungs. Ann Thorac Surg. 1970;10:163–8.CrossRefPubMed Jirsch DW, Fisk RL, Couves CM. Ex vivo evaluation of stored lungs. Ann Thorac Surg. 1970;10:163–8.CrossRefPubMed
25.
go back to reference Steen S, Sjoberg T, Pierre L, et al. Transplantation of lungs from a non-heart-beating donor. Lancet. 2001;357:825–9.CrossRefPubMed Steen S, Sjoberg T, Pierre L, et al. Transplantation of lungs from a non-heart-beating donor. Lancet. 2001;357:825–9.CrossRefPubMed
26.
go back to reference Zych B, Popov AF, Stavri G, et al. Early outcomes of bilateral sequential single lung transplantation after ex-vivo lung evaluation and reconditioning. J Heart Lung Transplant. 2012;31:274–81.CrossRefPubMed Zych B, Popov AF, Stavri G, et al. Early outcomes of bilateral sequential single lung transplantation after ex-vivo lung evaluation and reconditioning. J Heart Lung Transplant. 2012;31:274–81.CrossRefPubMed
27.
go back to reference Valenza F, Rosso L, Coppola S, et al. Ex vivo lung perfusion to improve donor lung function and increase the number of organs available for transplantation. Transplant Int. 2014;27:553–61.CrossRef Valenza F, Rosso L, Coppola S, et al. Ex vivo lung perfusion to improve donor lung function and increase the number of organs available for transplantation. Transplant Int. 2014;27:553–61.CrossRef
28.
go back to reference Stefan MS, Shieh MS, Pekow PS, et al. Epidermology and outcomes of acute respiratory failure in the United States, 2001 to 2009: A national survey. J Hosp Med. 2013;8:76–82.CrossRefPubMedPubMedCentral Stefan MS, Shieh MS, Pekow PS, et al. Epidermology and outcomes of acute respiratory failure in the United States, 2001 to 2009: A national survey. J Hosp Med. 2013;8:76–82.CrossRefPubMedPubMedCentral
29.
go back to reference The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000; 342: 1301–8.CrossRef The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000; 342: 1301–8.CrossRef
30.
go back to reference Brodie D, Bacchetta M. Extracorporeal membrane oxygenation for ARDS in adults. N Engl J Med. 2011;365:1905–14.CrossRefPubMed Brodie D, Bacchetta M. Extracorporeal membrane oxygenation for ARDS in adults. N Engl J Med. 2011;365:1905–14.CrossRefPubMed
31.
go back to reference Peek GJ, Tiruvoipati R, Wilson A, Allen E, Thalanany MM, Hibbert CL, Truesdale A, Clemens F, Cooper N, Firmin RK, Elbourne D, CESAR trial collaboration. Efficacy and economic assess ment of conventional ventilator support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomized controlled trial. Lancet. 2009;374:1351–63.CrossRefPubMed Peek GJ, Tiruvoipati R, Wilson A, Allen E, Thalanany MM, Hibbert CL, Truesdale A, Clemens F, Cooper N, Firmin RK, Elbourne D, CESAR trial collaboration. Efficacy and economic assess ment of conventional ventilator support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomized controlled trial. Lancet. 2009;374:1351–63.CrossRefPubMed
32.
go back to reference Wong JK, Melvin AL, Joshi DJ, Lee CY, Archibald WJ, Angona RE, Tchantchaleishvili V, Massey HT, Hicks GL, Knight PA. Cannulation-related complications on veno-arterial extracorporeal membrane oxygenation: prevalence and effect on mortality. Artif Organs. 2017; (Epub ahead of print). Wong JK, Melvin AL, Joshi DJ, Lee CY, Archibald WJ, Angona RE, Tchantchaleishvili V, Massey HT, Hicks GL, Knight PA. Cannulation-related complications on veno-arterial extracorporeal membrane oxygenation: prevalence and effect on mortality. Artif Organs. 2017; (Epub ahead of print).
33.
go back to reference Strueber M, Hoeper MM, Fischer S, Cypel M, Warnecke G, Gottlieb J, Pierre A, Welte T, Haverich A, Simon AR, Keshavjee S. Bridge to thoracic organ transplantation in patients with pulmonary arterial hypertension using a pumpless lung assist device. Am J Transplant. 2009;4:853–7.CrossRef Strueber M, Hoeper MM, Fischer S, Cypel M, Warnecke G, Gottlieb J, Pierre A, Welte T, Haverich A, Simon AR, Keshavjee S. Bridge to thoracic organ transplantation in patients with pulmonary arterial hypertension using a pumpless lung assist device. Am J Transplant. 2009;4:853–7.CrossRef
34.
go back to reference Schmid C, Philipp A, Hilker M, Arlt M, Trabold B, Pfeiffer M, Schmid FX. Bridge to lung transplantation through a pulmonary artery to left atrial oxygenator circuit. Ann Thorac Surg. 2008;85:1202–5.CrossRefPubMed Schmid C, Philipp A, Hilker M, Arlt M, Trabold B, Pfeiffer M, Schmid FX. Bridge to lung transplantation through a pulmonary artery to left atrial oxygenator circuit. Ann Thorac Surg. 2008;85:1202–5.CrossRefPubMed
35.
go back to reference Camboni D, Philipp A, Arlt M, Pfeiffer M, Hilker M, Schimid C. First experience with a paracorporeal artificial lung in humans. ASAIO J. 2009;55:304–6.CrossRefPubMed Camboni D, Philipp A, Arlt M, Pfeiffer M, Hilker M, Schimid C. First experience with a paracorporeal artificial lung in humans. ASAIO J. 2009;55:304–6.CrossRefPubMed
36.
go back to reference Muller T, Lubnow M, Philipp A, Bein T, Jeron A, Luchner A, Rupprecht L, Reng M, Langgartner J, Wrede CE, Zimmermann M, Birnbaum D, Schmid C, Riegger GA, Pfeifer M. Extracorporeal pumpless interventional lung assist in clinical practice: determinants of efficacy. Eur Respir J. 2009;33:551–8.CrossRefPubMed Muller T, Lubnow M, Philipp A, Bein T, Jeron A, Luchner A, Rupprecht L, Reng M, Langgartner J, Wrede CE, Zimmermann M, Birnbaum D, Schmid C, Riegger GA, Pfeifer M. Extracorporeal pumpless interventional lung assist in clinical practice: determinants of efficacy. Eur Respir J. 2009;33:551–8.CrossRefPubMed
37.
go back to reference Sato H, Hall CM, Lafayette NG, Pohlmann JR, Padiyar N, Toomasian JM, Haft JW, Cook KE. Thirty-day in parallel artificial lung testing in sheep. Ann Thorac Surg. 2007;84:1136–43.CrossRefPubMed Sato H, Hall CM, Lafayette NG, Pohlmann JR, Padiyar N, Toomasian JM, Haft JW, Cook KE. Thirty-day in parallel artificial lung testing in sheep. Ann Thorac Surg. 2007;84:1136–43.CrossRefPubMed
38.
go back to reference Skoog DJ, Pohlmann JR, Demos DS, Scipione CN, Iyengar A, Schewe RE, Suhaib AB, Koch KL, Cook KE. Fourteen day in vivo testing of a compliant thoracic artificial lung. ASAIO J. 2017;63:644–9.CrossRefPubMed Skoog DJ, Pohlmann JR, Demos DS, Scipione CN, Iyengar A, Schewe RE, Suhaib AB, Koch KL, Cook KE. Fourteen day in vivo testing of a compliant thoracic artificial lung. ASAIO J. 2017;63:644–9.CrossRefPubMed
39.
go back to reference Rose EA, Gelinjns AC, Moskowitz AJ, Heitjan DF, Stevenson LW, Dembitsky W, Long JW, Ascheim DD, Tierney AR, Levitan RG, Watson JT, Ronan NS, Shapiro PA, Lazar RM, Miller LW, Gupta L, Frazier H, Desvigne-Nickens P, Oz MC, Poirier VL, Meier P. Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure (REMATCH) Study Group. Long-term use of a left ventricular assist device for end-stage heart falure. N Engl J Med. 2001;345:1435–43.CrossRefPubMed Rose EA, Gelinjns AC, Moskowitz AJ, Heitjan DF, Stevenson LW, Dembitsky W, Long JW, Ascheim DD, Tierney AR, Levitan RG, Watson JT, Ronan NS, Shapiro PA, Lazar RM, Miller LW, Gupta L, Frazier H, Desvigne-Nickens P, Oz MC, Poirier VL, Meier P. Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure (REMATCH) Study Group. Long-term use of a left ventricular assist device for end-stage heart falure. N Engl J Med. 2001;345:1435–43.CrossRefPubMed
Metadata
Title
Extracorporeal lung support for advanced lung failure: a new era in thoracic surgery and translational science
Author
Norihisa Shigemura
Publication date
01-03-2018
Publisher
Springer Japan
Published in
General Thoracic and Cardiovascular Surgery / Issue 3/2018
Print ISSN: 1863-6705
Electronic ISSN: 1863-6713
DOI
https://doi.org/10.1007/s11748-017-0880-z

Other articles of this Issue 3/2018

General Thoracic and Cardiovascular Surgery 3/2018 Go to the issue