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Journal of Assisted Reproduction and Genetics
Published in: Journal of Assisted Reproduction and Genetics 2/2019

01-02-2019 | Review

Extracellular vesicle mediated embryo-endometrial cross talk during implantation and in pregnancy

Authors: Noble K. Kurian, Deepak Modi

Published in: Journal of Assisted Reproduction and Genetics | Issue 2/2019

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Abstract

Extracellular vesicles are lipoproteinaceous membrane-enclosed nanometer-sized structures produced by cells and are thought to mediate cellular communications. Loaded with a specific set of miRNA and protein depending on their tissue of origin, these extracellular vesicles modulate diverse set of biological processes in their target tissues. In recent years, data has gathered on the roles of extracellular vesicles in embryo implantation and pregnancy. Embryo, oviduct, endometrial epithelium and stroma/decidua derived vesicles interact with trophoblast cells and promote their growth and differentiation to aid in embryo implantation. The placental vesicles are detected in maternal circulation that aids in feto-maternal immune tolerance, their levels vary in women with pregnancy-related complications like preeclampsia. Beyond the host, the microbes in the genital tract are also reported to produce extracellular vesicles which are thought to be responsible for inflammation and preterm births. This review focuses on the extracellular vesicular trafficking involved in success of pregnancy.
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Metadata
Title
Extracellular vesicle mediated embryo-endometrial cross talk during implantation and in pregnancy
Authors
Noble K. Kurian
Deepak Modi
Publication date
01-02-2019
Publisher
Springer US
Published in
Journal of Assisted Reproduction and Genetics / Issue 2/2019
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI
https://doi.org/10.1007/s10815-018-1343-x

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