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01-04-2004 | Review

Extra-osseous involvement of Langerhans’ cell histiocytosis in children

Authors: Sabine Schmidt, Georg Eich, Sylviane Hanquinet, Heinz Tschäppeler, Peter Waibel, François Gudinchet

Published in: Pediatric Radiology | Issue 4/2004

Abstract

The predominant clinical and radiological features of Langerhans’ cell histiocytosis (LCH) in children are due to osseous involvement. Extra-osseous disease is far less common, occurring in association with bone disease or in isolation; nearly all anatomical sites may be affected and in very various combinations. The following article is based on a multicentre review of 31 children with extra-osseous LCH. The objective is to summarise the diverse possibilities of organ involvement. The radiological manifestations using different imaging modalities are rarely pathognomonic on their own. Nevertheless, familiarity with the imaging findings, especially in children with systemic disease, may be essential for early diagnosis.

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Title: Extra-osseous involvement of Langerhans’ cell histiocytosis in children
Authors: Sabine Schmidt
Georg Eich
Sylviane Hanquinet
Heinz Tschäppeler
Peter Waibel
François Gudinchet
Publication date: 01-04-2004
Publisher: Springer-Verlag
Published in: Pediatric Radiology / Issue 4/2004
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-003-1118-z

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Extra-osseous involvement of Langerhans’ cell histiocytosis in children

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