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Magnetic Resonance Materials in Physics, Biology and Medicine

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Open Access 06-02-2023 | Research Article

Extra-axonal contribution to double diffusion encoding-based pore size estimates in the corticospinal tract

Authors: Patricia Ulloa, Vincent Methot, Viktor Wottschel, Martin A. Koch

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 4/2023

Abstract

Objective

To study the origin of compartment size overestimation in double diffusion encoding MRI (DDE) in vivo experiments in the human corticospinal tract. Here, the extracellular space is hypothesized to be the origin of the DDE signal. By exploiting the DDE sensitivity to pore shape, it could be possible to identify the origin of the measured signal. The signal difference between parallel and perpendicular diffusion gradient orientation can indicate if a compartment is regular or eccentric in shape. As extracellular space can be considered an eccentric compartment, a positive difference would mean a high contribution to the compartment size estimates.

Materials and methods

Computer simulations using MISST and in vivo experiments in eight healthy volunteers were performed. DDE experiments using a double spin-echo preparation with eight perpendicular directions were measured in vivo. The difference between parallel and perpendicular gradient orientations was analyzed using a Wilcoxon signed-rank test and a Mann–Whitney U test.

Results

Simulations and MR experiments showed a statistically significant difference between parallel and perpendicular diffusion gradient orientation signals (\(\alpha =0.05\)).

Conclusion

The results suggest that the DDE-based size estimate may be considerably influenced by the extra-axonal compartment. However, the experimental results are also consistent with purely intra-axonal contributions in combination with a large fiber orientation dispersion.

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Title: Extra-axonal contribution to double diffusion encoding-based pore size estimates in the corticospinal tract
Authors: Patricia Ulloa
Vincent Methot
Viktor Wottschel
Martin A. Koch
Publication date: 06-02-2023
Publisher: Springer International Publishing
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 4/2023
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-022-01058-8

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Extra-axonal contribution to double diffusion encoding-based pore size estimates in the corticospinal tract

Abstract

Objective

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Materials and methods

Results

Conclusion

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