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Trials
Published in: Trials 2/2015

Open Access 01-12-2015 | Poster presentation

External validity of rct evidence in cost-effectiveness analyses. A review of recent technology appraisals for nice and proposed methods of adjustment

Authors: Theodoros Mantopoulos, Sofia Dias, Antony Ades, Nicky Welton

Published in: Trials | Special Issue 2/2015

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Excerpt

Randomised Controlled Trials (RCTs) produce relative treatment effects that have high internal validity. However they may suffer from lack of external validity when used as inputs to cost-effectiveness analyses (CEA). If differences in RCT and CEA populations can be described by a set of observed covariates, then it is possible to adjust for these differences. A common approach is to estimate effects at the mean covariate values. For non-linear models this introduces bias, even if the RCT and CEA populations are comparable. …
Metadata
Title
External validity of rct evidence in cost-effectiveness analyses. A review of recent technology appraisals for nice and proposed methods of adjustment
Authors
Theodoros Mantopoulos
Sofia Dias
Antony Ades
Nicky Welton
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Trials / Issue Special Issue 2/2015
Electronic ISSN: 1745-6215
DOI
https://doi.org/10.1186/1745-6215-16-S2-P25

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