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01-06-2013 | Clinical Study

Expression of RACGAP1 in high grade meningiomas: a potential role in cancer progression

Authors: Hong-Lin Ke, Rong-Hu Ke, Shi-Ting Li, Bin Li, Hai-Tao Lu, Xiao-Qiang Wang

Published in: Journal of Neuro-Oncology | Issue 2/2013

Abstract

Recently, Rac GTPase-activating protein 1 (RACGAP1) has been shown to have a critical role in various tumors. The aim of the present study was to investigate the expression of RACGAP1 in human meningiomas and to compare these results with the clinicopathological parameters. Thirty-two cases, classified as 13 World Health Organization grade I (40.6 %), 10 grade II (31.3 %) and 9 grade III (28.1 %) primary meningiomas, were selected from our pathological files. Clinico-pathological data, including survival data, were also available. RACGAP1 expression in the meningiomas was measured by real-time quantitative PCR and western blot. Our results showed the level of RACGAP1 expression in grade III meningioma is higher than that of grade I. Higher levels of RACGAP1 mRNA were significantly correlated with tumor size, higher Simpson grade, histological type and clinical course (P < 0.05). Furthermore, the level of RACGAP1 expression mRNA was positively correlated with MIB-1 labeling index in different meningiomas tissue (r ² = 0.3237, P = 0.0007). Additionally, Kaplan–Meier curves demonstrated a significantly worse survival in patients with high levels of RACGAP1 mRNA (P = 0.008). In conclusion, these findings suggest that RACGAP1 may be used as a potential predictor for tumor proliferative and patient prognosis in meningiomas.

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Title: Expression of RACGAP1 in high grade meningiomas: a potential role in cancer progression
Authors: Hong-Lin Ke
Rong-Hu Ke
Shi-Ting Li
Bin Li
Hai-Tao Lu
Xiao-Qiang Wang
Publication date: 01-06-2013
Publisher: Springer US
Published in: Journal of Neuro-Oncology / Issue 2/2013
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-013-1121-7

At a glance: The STEP trials

Springer Medicine

Expression of RACGAP1 in high grade meningiomas: a potential role in cancer progression

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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