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01-09-2015 | Case Report

Expression of nNOS in the human larynx

Authors: Mircea Şelaru, Mugurel Constantin Rusu, Adelina Maria Jianu

Published in: Anatomical Science International | Issue 4/2015

Abstract

Although intrinsic laryngeal neurons and ganglia have been studied in various species, they have been overlooked in humans. We aimed to investigate the presence of intrinsic laryngeal neurons in humans and, if present, to analyze their neuronal nitric oxide synthase (nNOS) expression. An immunohistochemical study using anti-nNOS antibodies was performed on samples obtained from four cadavers. Intrinsic laryngeal nNOS+ neurons were assessed in the submucosal layer, but nNOS+ nerves were found in all histological layers of the larynx. nNOS expression was also found in striated muscle fibers of larynx. This might reveal the anatomical basis of an upwards extension of the nonadrenergic noncholinergic system in human airways, but further experiments are needed to assess an exact role of NO influence on neural transmission and muscular functions of human larynx.

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Title: Expression of nNOS in the human larynx
Authors: Mircea Şelaru
Mugurel Constantin Rusu
Adelina Maria Jianu
Publication date: 01-09-2015
Publisher: Springer Japan
Published in: Anatomical Science International / Issue 4/2015
Print ISSN: 1447-6959
Electronic ISSN: 1447-073X
DOI: https://doi.org/10.1007/s12565-015-0272-3

At a glance: The STEP trials

Springer Medicine

Expression of nNOS in the human larynx

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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