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BMC Urology
Published in: BMC Urology 1/2009

Open Access 01-12-2009 | Research article

Expression of multidrug resistance markers ABCB1 (MDR-1/P-gp) and ABCC1 (MRP-1) in renal cell carcinoma

Authors: Naomi Walsh, Annemarie Larkin, Susan Kennedy, Lisa Connolly, Jo Ballot, Wei Ooi, Giuseppe Gullo, John Crown, Martin Clynes, Lorraine O'Driscoll

Published in: BMC Urology | Issue 1/2009

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Abstract

Background

Renal cell carcinoma patients respond poorly to conventional chemotherapy, this unresponsiveness may be attributable to multidrug resistance (MDR). The mechanisms of MDR in renal cancer are not fully understood and the specific contribution of ABC transporter proteins which have been implicated in the chemoresistance of various cancers has not been fully defined in this disease.

Methods

In this retrospective study the expression of two of these transporter efflux pumps, namely MDR-1 P-gp (ABCB1) and MRP-1 (ABCC1) were studied by immunohistochemistry in archival material from 95 renal cell carcinoma patients.

Results

In the first study investigating MDR-1 P-gp and MRP-1 protein expression patterns in renal cell carcinoma patients, high levels of expression of both efflux pumps are observed with 100% of tumours studied showing MDR-1 P-gp and MRP-1 positivity.

Conclusion

Although these findings do not prove a causal role, the high frequency of tumours expressing these efflux pumps suggests that they may be important contributors to the chemoresistance of this tumour type.
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Metadata
Title
Expression of multidrug resistance markers ABCB1 (MDR-1/P-gp) and ABCC1 (MRP-1) in renal cell carcinoma
Authors
Naomi Walsh
Annemarie Larkin
Susan Kennedy
Lisa Connolly
Jo Ballot
Wei Ooi
Giuseppe Gullo
John Crown
Martin Clynes
Lorraine O'Driscoll
Publication date
01-12-2009
Publisher
BioMed Central
Published in
BMC Urology / Issue 1/2009
Electronic ISSN: 1471-2490
DOI
https://doi.org/10.1186/1471-2490-9-6

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