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Head & Neck Oncology
Published in: Head & Neck Oncology 1/2012

Open Access 01-12-2012 | Case report

Expression of Glut-1, HIF-1α, PI3K and p-Akt in a case of ceruminous adenoma

Authors: Wan-Qin Shen, Ke-Jia Cheng, Yang-Yang Bao, Shui-Hong Zhou, Hong-Tian Yao

Published in: Head & Neck Oncology | Issue 1/2012

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Abstract

Objectives

Ceruminous adenoma of the external auditory canal (EAC) is a rare type of tumour that is diagnosed histologically. However, the clinical behaviour of these tumours remains controversial. Here, we report a case of ceruminous adenoma of the EAC and expression of a hypoxia marker.

Case report

A 78-year-old man presented with a 6-month history of recurrent otorrhoea in the right ear. Surgery was performed by the transmeatal approach with total removal of the mass. Histopathology revealed a ceruminous adenoma. Tumour cells were positive for CK, S-100 protein, Glut-1, HIF-1α, PI3K and p-Akt. There was no evidence of recurrence at last follow-up 27 months after the operation.

Conclusions

Ceruminous adenoma of the EAC is a rare tumour. The treatment of choice is wide local excision with clear margins. To our knowledge, this is the first report of Glut-1 expression and the PI3K/Akt pathway in ceruminous adenoma of the EAC.
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Metadata
Title
Expression of Glut-1, HIF-1α, PI3K and p-Akt in a case of ceruminous adenoma
Authors
Wan-Qin Shen
Ke-Jia Cheng
Yang-Yang Bao
Shui-Hong Zhou
Hong-Tian Yao
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Head & Neck Oncology / Issue 1/2012
Electronic ISSN: 1758-3284
DOI
https://doi.org/10.1186/1758-3284-4-18

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