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Endocrine
Published in: Endocrine 3/2011

01-12-2011 | Original Article

Expression of galanin and galanin receptor mRNA in skin during the formation of granulation tissue

Authors: Hiroyuki Yamamoto, Takeo Arai, Shinta Ben, Kazuaki Iguchi, Minoru Hoshino

Published in: Endocrine | Issue 3/2011

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Abstract

Galanin is a neuropeptide widely distributed in the central and peripheral nervous systems. Although its role in non-neural cells is poorly understood, it is known that during inflammation, the dermis layer of the skin produces and releases galanin. The aim of this report is to study the expression of galanin in granulation tissue. After inducing inflammation by cotton thread implantation, galanin-like immunoreactivity (galanin-LI) in plasma reached a maximum on the third day. Galanin-LI was observed in fibroblast-like cells occurring close to collagen fibers in developing granulation tissue. Furthermore, galanin receptor subtypes 1 and 2 (GALR1 and GALR2)-expressing cells were observed around microvessels and were found to produce desmin. Galanin was injected along the cotton threads immediately after implantation, resulting in rapid formation of granulation tissue, and an increase in the contents of microvessels, indicating a stimulatory effect of galanin on the process of angiogenesis in granulation tissue. The results demonstrate that some galanin was released from fibroblast-like cells during the formation of granulation tissue, and that it stimulated angiogenesis.
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Metadata
Title
Expression of galanin and galanin receptor mRNA in skin during the formation of granulation tissue
Authors
Hiroyuki Yamamoto
Takeo Arai
Shinta Ben
Kazuaki Iguchi
Minoru Hoshino
Publication date
01-12-2011
Publisher
Springer US
Published in
Endocrine / Issue 3/2011
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-011-9529-3

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