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European Archives of Oto-Rhino-Laryngology

Published in:

01-07-2018 | Head and Neck

Expression of cancer stem cell markers CD44, ALDH1 and p75NTR in actinic cheilitis and lip cancer

Authors: Marcos Custódio, Cibele Pelissari, Thalita Santana, Marília Trierveiler

Published in: European Archives of Oto-Rhino-Laryngology | Issue 7/2018

Abstract

Purpose

The aim of this work was to evaluate the expression of the cancer stem cell (CSC) markers CD44, ALDH1 and p75NTR in the ultraviolet-induced lesions actinic cheilitis (AC) and lip squamous cell carcinoma (LSCC), and to correlate it with p53 expression.

Methods

Immunohistochemistry was performed in 4 cases of normal lip (NL), 43 of AC and 20 of LSCC.

Results

All cases were positive for CD44, showing a membranous staining without differences between the groups. ALDH1 showed cytoplasmic staining and it was invariable amongst the grades of epithelial dysplasia and between AC and LSCC. p75NTR presented membranous/cytoplasmic staining in the basal and parabasal layer of NL and AC, while LSCC presented cytoplasmic staining in the peripheral layers of the tumor islands. p75NTR showed different expression amongst the dysplasia grades (p < 0.001) but no differences between AC and LSCC. p53 expression was similar amongst the dysplasia grades and between AC and LSCC. CD44, ALDH1 and p75NTR were unrelated amongst themselves and to p53 expression.

Conclusions

CSC markers are expressed in potentially malignant and malignant lesions of the lip. Their expressions were invariable between AC and LSCC and unrelated to p53. p75NTR expression increased with the worsening of epithelial dysplasia grade.

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Title: Expression of cancer stem cell markers CD44, ALDH1 and p75NTR in actinic cheilitis and lip cancer
Authors: Marcos Custódio
Cibele Pelissari
Thalita Santana
Marília Trierveiler
Publication date: 01-07-2018
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Oto-Rhino-Laryngology / Issue 7/2018
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-018-5002-8

At a glance: The STEP trials

Springer Medicine

Expression of cancer stem cell markers CD44, ALDH1 and p75NTR in actinic cheilitis and lip cancer

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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