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01-04-2005 | Regular Paper

Expression of 8-oxoguanine DNA glycosylase (OGG1) in Parkinson’s disease and related neurodegenerative disorders

Authors: Jiro Fukae, Masashi Takanashi, Shin-ichiro Kubo, Ken-ichi Nishioka, Yusaku Nakabeppu, Hideo Mori, Yoshikuni Mizuno, Nobutaka Hattori

Published in: Acta Neuropathologica | Issue 3/2005

Abstract

Oxidative stress including DNA oxidation is implicated in Parkinson’s disease (PD). We postulated that DNA repair enzymes such as 8-oxoguanosine DNA glycosylase (OGG1) are involved in the PD process. We performed immunohistochemical and biochemical studies on brains of patients with PD and those of patients with progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) as disease controls, and control subjects. We found higher expression levels of mitochondrial isoforms of OGG1 enzymes in the substantia nigra (SN) in cases of PD. Furthermore, Western blot analysis revealed high OGG1 levels in the SN of the patients with PD. Our results indicate the importance of oxidative stress within the susceptible lesions in the pathogenesis of PD.

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Title: Expression of 8-oxoguanine DNA glycosylase (OGG1) in Parkinson’s disease and related neurodegenerative disorders
Authors: Jiro Fukae
Masashi Takanashi
Shin-ichiro Kubo
Ken-ichi Nishioka
Yusaku Nakabeppu
Hideo Mori
Yoshikuni Mizuno
Nobutaka Hattori
Publication date: 01-04-2005
Publisher: Springer-Verlag
Published in: Acta Neuropathologica / Issue 3/2005
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-004-0937-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Expression of 8-oxoguanine DNA glycosylase (OGG1) in Parkinson’s disease and related neurodegenerative disorders

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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