Published in:
Open Access
01-12-2015 | Meeting abstract
Experimental model of type 2 diabetes induced by fat diet consumption and low dose of streptozotocin in C57BL/6J mice
Authors:
Mariana de Freitas Moreira, Natalia do Vale Canabrava, Sandra Machado Lira, Tatiane Rodrigues Oliveira, José Ytalo Gomes da Silva, Marcelo Oliveira Holanda, Carla Laíne Silva Lima, Julianne do Nascimento Sales, Arnaldo Solheiro Bezerra, Bruno Bezerra da Silva, Erlândia Alves Magalhães Queiroz, Paula Alves Salmito Rodrigues, Raquel Teixeira Terceiro Paim, Lia Magalhães de Almeida, Maria Izabel Florindo Guedes
Published in:
Diabetology & Metabolic Syndrome
|
Special Issue 1/2015
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Excerpt
Studies with murine model have been extensively used as a tool in the understanding of mechanisms involved in diseases such as diabetes (Correia-Santos et al, 2012; Chorilli, 2007). Diabetes is characterized as a heterogeneous group of metabolic disorders having in common hyperglycemia, which may result from defects in insulin action or secretion or even in both. The same can be divided into four groups: type 1 diabetes mellitus (DM1), type 2 diabetes mellitus (DM2), gestational diabetes mellitus, and other specific types of diabetes (SBD, 2014). It is known that DM2 is associated with overweight and obesity, physical inactivity, metabolic syndrome, diet high in saturated and animal fat, among others. (Paulweber et al., 2010). …
