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Open Access 01-10-2017 | Original Research

Experiences of Pre-Implantation Genetic Diagnosis (PGD) in Sweden: a Three-Year Follow-Up of Men and Women

Authors: Stina Järvholm, Ann Thurin-Kjellberg, Malin Broberg

Published in: Journal of Genetic Counseling | Issue 5/2017

Abstract

Men and women with a hereditary genetic disease are faced with different options when they wish to become parents. One is pre-implantation genetic diagnosis (PGD) which is a combination of in vitro fertilization (IVF) and genetic analysis of the embryo before implantation. The present study focused on men and women’s psychological experiences of PGD three years after applying for PGD. Nineteen women and seventeen men (i.e. seventeen couples and two women) participated. The interviews were analysed by thematic method. It is better to have tried was identified as a master theme, under which came three underlying sub-themes, which had the following headings: Practical experience of PGD, Psychological experience of PGD and Goals of PGD. The results show that men and women three years after PGD are still psychologically affected by their experience. The men and women raised concerns that their relationship had been affected, both positively and negatively, and feelings of anxiety and depression still remained. Healthcare services should recognize the heterogeneous nature of the group being studied and therefore the need for counselling can arise at different times and in relation to different areas, regardless of the outcome of the PGD.

Bayat, N., Alishiri, G. H., Salimzadeh, A., Izadi, M., Saleh, D. K., Lankarani, M. M., & Assari, S. (2011). Symptoms of anxiety and depression: a comparison among patients with different chronic conditions. Journal of Research in Medical Sciences, 16(11), 1441–1447.PubMedPubMedCentral

Braun, V., & Clarke, V. (2006). Using thematic analysis in psychology. Qualitative Research in Psychology, 3(2), 77–101.CrossRef

El Kissi, Y., Romdhane, A. B., Hidar, S., Bannour, S., Idrissi, K. A., Khairi, H., & Ali, B. B. H. (2013). General psychopathology, anxiety, depression and self-esteem in couples undergoing infertility treatment: a comparative study between men and women. European Journal of Obstetrics & Gynecology and Reproductive Biology, 167(2), 185–189.CrossRef

Ferraretti, A. P., Goossens, V., Kupka, M., Bhattacharya, S., de Mouzon, J., Castilla, J. A.,… Embryology. (2013). Assisted reproductive technology in Europe, 2009: results generated from European registers by ESHRE. Human reproduction (Oxford, England), 28(9), 2318.

Gourounti, K., Anagnostopoulos, F., Potamianos, G., Lykeridou, K., Schmidt, L., & Vaslamatzis, G. (2012). Perception of control, coping and psychological stress of infertile women undergoing IVF. Reproductive Biomedicine Online, 24(6), 670–679.CrossRefPubMed

Hershberger, P. E., & Pierce, P. F. (2010). Conceptualizing couples’ decision making in PGD: emerging cognitive, emotional, and moral dimensions. Patient Education and Counseling, 81(1), 53–62.CrossRefPubMedPubMedCentral

Hershberger, P. E., Gallo, A. M., Kavanaugh, K., Olshansky, E., Schwartz, A., & Tur-Kaspa, I. (2012). The decision-making process of genetically at-risk couples considering preimplantation genetic diagnosis: initial findings from a grounded theory study. Social Science & Medicine, 74(10), 1536–1543.CrossRef

Huppelschoten, A., Van Dongen, A., Verhaak, C., Smeenk, J., Kremer, J., & Nelen, W. (2013). Differences in quality of life and emotional status between infertile women and their partners. Human Reproduction. doi:10.1093/humrep/det239.

Järvholm, S., Broberg, M., & Thurin-Kjellberg, A. (2014). The choice of pre-implantation genetic diagnosis (PGD), a qualitative study among men and women. Journal of Reproductive and Infant Psychology, 32(1), 57–69.CrossRef

Järvholm, S., Broberg, M., & Thurin-Kjellberg, A. (2016). Risk factors for depression and anxiety among men and women planning for pre-implantation genetic diagnosis. Journal of Reproductive and Infant Psychology, 34(3), 282.CrossRef

Karatas, J. C., Strong, K. A., Barlow-Stewart, K., McMahon, C., Meiser, B., & Roberts, C. (2010). Psychological impact of preimplantation genetic diagnosis: a review of the literature. Reproductive Biomedicine Online, 20(1), 83–91.CrossRefPubMed

Karatas, J. C., Barlow-Stewart, K., Meiser, B., McMahon, C., Strong, K. A., Hill, W., et al. (2011). A prospective study assessing anxiety, depression and maternal-fetal attachment in women using PGD. Human Reproduction, 26(1), 148–156.CrossRefPubMed

Korenromp, M. J. (2009). Adjustment to termination of pregnancy for fetal anomaly: a longitudinal study in women at 4, 8, and 16 months. Am J Obstet Gynecol, 201(2), 160.e161–160.e167.CrossRef

Liebaers, I., Desmyttere, S., Verpoest, W., De Rycke, M., Staessen, C., Sermon, K., et al. (2010). Report on a consecutive series of 581 children born after blastomere biopsy for preimplantation genetic diagnosis. Human Reproduction, 25(1), 275–282.CrossRefPubMed

Lok, I. H., & Neugebauer, R. (2007). Psychological morbidity following miscarriage. Best Practice & Research Clinical Obstetrics & Gynaecology, 21(2), 229–247.CrossRef

Peterson, B. D., Newton, C. R., Rosen, K. H., & Skaggs, G. E. (2006). Gender differences in how men and women who are referred for IVF cope with infertility stress. Human Reproduction (Oxford, England), 21(9), 2443–2449.CrossRef

Preedy, V. R., & Watson, R. R. (2010). Handbook of disease burdens and quality of life measures. New York: Springer.CrossRef

Verpoest, W., Haentjens, P., De Rycke, M., Staessen, C., Sermon, K., Bonduelle, M., et al. (2009). Cumulative reproductive outcome after preimplantation genetic diagnosis: a report on 1498 couples. Human Reproduction, 24(11), 2951–2959.CrossRefPubMed

Wichman, C. L., Ehlers, S. L., Wichman, S. E., Weaver, A. L., & Coddington, C. (2011). Comparison of multiple psychological distress measures between men and women preparing for in vitro fertilization. Fertility and Sterility, 95(2), 717–721.CrossRefPubMed

Zeiler, K. (2007). Shared decision-making, gender and new technologies. Medicine, Health Care and Philosophy, 10(3), 279–287.CrossRef

Title: Experiences of Pre-Implantation Genetic Diagnosis (PGD) in Sweden: a Three-Year Follow-Up of Men and Women
Authors: Stina Järvholm
Ann Thurin-Kjellberg
Malin Broberg
Publication date: 01-10-2017
Publisher: Springer US
Published in: Journal of Genetic Counseling / Issue 5/2017
Print ISSN: 1059-7700
Electronic ISSN: 1573-3599
DOI: https://doi.org/10.1007/s10897-017-0078-7

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Experiences of Pre-Implantation Genetic Diagnosis (PGD) in Sweden: a Three-Year Follow-Up of Men and Women

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