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Behavioral and Brain Functions
Published in: Behavioral and Brain Functions 1/2015

Open Access 01-12-2015 | Review

Expanding the toolbox of ADHD genetics. How can we make sense of parent of origin effects in ADHD and related behavioral phenotypes?

Authors: Tetyana Zayats, Stefan Johansson, Jan Haavik

Published in: Behavioral and Brain Functions | Issue 1/2015

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Abstract

Genome-wide association (GWA) studies have shown that many different genetic variants cumulatively contribute to the risk of psychiatric disorders. It has also been demonstrated that various parent-of-origin effects (POE) may differentially influence the risk of these disorders. Together, these observations have provided important new possibilities to uncover the genetic underpinnings of such complex phenotypes. As POE so far have received little attention in neuropsychiatric disorders, there is still much progress to be made. Here, we mainly focus on the new and emerging role of POE in attention-deficit hyperactivity disorder (ADHD). We review the current evidence that POE play an imperative role in vulnerability to ADHD and related disorders. We also discuss how POE can be assessed using statistical genetics tools, expanding the resources of modern psychiatric genetics. We propose that better comprehension and inspection of POE may offer new insight into the molecular basis of ADHD and related phenotypes, as well as the potential for preventive and therapeutic interventions.
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Metadata
Title
Expanding the toolbox of ADHD genetics. How can we make sense of parent of origin effects in ADHD and related behavioral phenotypes?
Authors
Tetyana Zayats
Stefan Johansson
Jan Haavik
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Behavioral and Brain Functions / Issue 1/2015
Electronic ISSN: 1744-9081
DOI
https://doi.org/10.1186/s12993-015-0078-4

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