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Published in: Current Geriatrics Reports 3/2016

01-09-2016 | Physical Therapy and Rehabilitation (O Addison, Section Editor)

Exercise in Type 2 Diabetic Peripheral Neuropathy

Authors: Arwen A. Fuller, J. Robinson Singleton, A. Gordon Smith, Robin L. Marcus

Published in: Current Geriatrics Reports | Issue 3/2016

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Abstract

Approximately half of all patients with type 2 diabetes develop peripheral neuropathy, which contributes to functional decline and significantly reduces quality of life. Type 2 diabetes and consequent diabetic peripheral neuropathy share several pathogenic mechanisms and are both positively influenced by increased physical activity and exercise even prior to disease diagnosis. Successful exercise interventions in individuals with diabetic peripheral neuropathy have employed continuous endurance, resistance, balance and agility, and high-intensity interval training protocols and have been associated with improvement in stability, gait, sensory function, nerve regeneration rates, pain, mood, and quality of life. Recent evidence has shown no increased prevalence of foot trauma in those with diabetic peripheral neuropathy suggesting that weight-bearing exercise is safe in the absence of active ulceration. While exercise is often associated with improved glycemic control, several studies suggest improvement in neuropathy is independent of improved glycemic control or weight reduction, suggesting other metabolic effects, or exercise-related physiologic changes are important.
Literature
1.
go back to reference Corriveau H et al. Evaluation of postural stability in elderly with diabetic neuropathy. Diabetes Care. 2000;23(8):1187–91.PubMedCrossRef Corriveau H et al. Evaluation of postural stability in elderly with diabetic neuropathy. Diabetes Care. 2000;23(8):1187–91.PubMedCrossRef
2.
go back to reference Gordois A et al. The health care costs of diabetic peripheral neuropathy in the US. Diabetes Care. 2003;26(6):1790–5.PubMedCrossRef Gordois A et al. The health care costs of diabetic peripheral neuropathy in the US. Diabetes Care. 2003;26(6):1790–5.PubMedCrossRef
3.
go back to reference Mueller MJ et al. Insensitivity, limited joint mobility, and plantar ulcers in patients with diabetes mellitus. Phys Ther. 1989;69(6):453–9. discussion 459–62.PubMed Mueller MJ et al. Insensitivity, limited joint mobility, and plantar ulcers in patients with diabetes mellitus. Phys Ther. 1989;69(6):453–9. discussion 459–62.PubMed
4.••
go back to reference Singleton JR et al. Supervised exercise improves cutaneous reinnervation capacity in metabolic syndrome patients. Ann Neurol. 2015;77(1):146–53. Exercise induced changes in metabolic syndrome features affect changes in cutaneous regenerative capacity. PubMedCrossRef Singleton JR et al. Supervised exercise improves cutaneous reinnervation capacity in metabolic syndrome patients. Ann Neurol. 2015;77(1):146–53. Exercise induced changes in metabolic syndrome features affect changes in cutaneous regenerative capacity. PubMedCrossRef
5.
6.
go back to reference Dubois SG et al. Decreased expression of adipogenic genes in obese subjects with type 2 diabetes. Obesity (Silver Spring). 2006;14(9):1543–52.CrossRef Dubois SG et al. Decreased expression of adipogenic genes in obese subjects with type 2 diabetes. Obesity (Silver Spring). 2006;14(9):1543–52.CrossRef
7.
go back to reference Pasarica M et al. Differential effect of weight loss on adipocyte size subfractions in patients with type 2 diabetes. Obesity (Silver Spring). 2009;17(10):1976–8.CrossRef Pasarica M et al. Differential effect of weight loss on adipocyte size subfractions in patients with type 2 diabetes. Obesity (Silver Spring). 2009;17(10):1976–8.CrossRef
8.
go back to reference Ye J. Emerging role of adipose tissue hypoxia in obesity and insulin resistance. Int J Obes (Lond). 2009;33(1):54–66.CrossRef Ye J. Emerging role of adipose tissue hypoxia in obesity and insulin resistance. Int J Obes (Lond). 2009;33(1):54–66.CrossRef
9.
go back to reference Zhou QG et al. Advanced oxidation protein products induce inflammatory response and insulin resistance in cultured adipocytes via induction of endoplasmic reticulum stress. Cell Physiol Biochem. 2010;26(4–5):775–86.PubMedCrossRef Zhou QG et al. Advanced oxidation protein products induce inflammatory response and insulin resistance in cultured adipocytes via induction of endoplasmic reticulum stress. Cell Physiol Biochem. 2010;26(4–5):775–86.PubMedCrossRef
10.
go back to reference Mootha VK et al. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet. 2003;34(3):267–73.PubMedCrossRef Mootha VK et al. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet. 2003;34(3):267–73.PubMedCrossRef
12.
go back to reference Lowell BB, Shulman GI. Mitochondrial dysfunction and type 2 diabetes. Science. 2005;307(5708):384–7.PubMedCrossRef Lowell BB, Shulman GI. Mitochondrial dysfunction and type 2 diabetes. Science. 2005;307(5708):384–7.PubMedCrossRef
13.
go back to reference DeFronzo RA, Bonadonna RC, Ferrannini E. Pathogenesis of NIDDM. A balanced overview. Diabetes Care. 1992;15(3):318–68.PubMedCrossRef DeFronzo RA, Bonadonna RC, Ferrannini E. Pathogenesis of NIDDM. A balanced overview. Diabetes Care. 1992;15(3):318–68.PubMedCrossRef
14.
go back to reference Gulli G et al. The metabolic profile of NIDDM is fully established in glucose-tolerant offspring of two Mexican-American NIDDM parents. Diabetes. 1992;41(12):1575–86.PubMedCrossRef Gulli G et al. The metabolic profile of NIDDM is fully established in glucose-tolerant offspring of two Mexican-American NIDDM parents. Diabetes. 1992;41(12):1575–86.PubMedCrossRef
15.
go back to reference Vaag A, Henriksen JE, Beck-Nielsen H. Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus. J Clin Invest. 1992;89(3):782–8.PubMedPubMedCentralCrossRef Vaag A, Henriksen JE, Beck-Nielsen H. Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus. J Clin Invest. 1992;89(3):782–8.PubMedPubMedCentralCrossRef
16.
go back to reference Weyer C et al. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest. 1999;104(6):787–94.PubMedPubMedCentralCrossRef Weyer C et al. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest. 1999;104(6):787–94.PubMedPubMedCentralCrossRef
17.
go back to reference Kim B et al. Hyperglycemia-induced tau cleavage in vitro and in vivo: a possible link between diabetes and Alzheimer’s disease. J Alzheimers Dis. 2013;34(3):727–39.PubMed Kim B et al. Hyperglycemia-induced tau cleavage in vitro and in vivo: a possible link between diabetes and Alzheimer’s disease. J Alzheimers Dis. 2013;34(3):727–39.PubMed
20.
go back to reference Vincent AM et al. Mitochondrial biogenesis and fission in axons in cell culture and animal models of diabetic neuropathy. Acta Neuropathol. 2010;120(4):477–89.PubMedPubMedCentralCrossRef Vincent AM et al. Mitochondrial biogenesis and fission in axons in cell culture and animal models of diabetic neuropathy. Acta Neuropathol. 2010;120(4):477–89.PubMedPubMedCentralCrossRef
22.
go back to reference Bays HE. Adiposopathy is “sick fat” a cardiovascular disease? J Am Coll Cardiol. 2011;57(25):2461–73.PubMedCrossRef Bays HE. Adiposopathy is “sick fat” a cardiovascular disease? J Am Coll Cardiol. 2011;57(25):2461–73.PubMedCrossRef
23.
go back to reference Wong KL et al. Palmitic acid-induced lipotoxicity and protection by (+)-catechin in rat cortical astrocytes. Pharmacol Rep. 2014;66(6):1106–13.PubMedCrossRef Wong KL et al. Palmitic acid-induced lipotoxicity and protection by (+)-catechin in rat cortical astrocytes. Pharmacol Rep. 2014;66(6):1106–13.PubMedCrossRef
24.
go back to reference Pratipanawatr W et al. Skeletal muscle insulin resistance in normoglycemic subjects with a strong family history of type 2 diabetes is associated with decreased insulin-stimulated insulin receptor substrate-1 tyrosine phosphorylation. Diabetes. 2001;50(11):2572–8.PubMedCrossRef Pratipanawatr W et al. Skeletal muscle insulin resistance in normoglycemic subjects with a strong family history of type 2 diabetes is associated with decreased insulin-stimulated insulin receptor substrate-1 tyrosine phosphorylation. Diabetes. 2001;50(11):2572–8.PubMedCrossRef
25.
go back to reference Petersen KF, Dufour S, Shulman GI. Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents. PLoS Med. 2005;2(9):e233.PubMedPubMedCentralCrossRef Petersen KF, Dufour S, Shulman GI. Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents. PLoS Med. 2005;2(9):e233.PubMedPubMedCentralCrossRef
26.
go back to reference Kashyap SR et al. Discordant effects of a chronic physiological increase in plasma FFA on insulin signaling in healthy subjects with or without a family history of type 2 diabetes. Am J Physiol Endocrinol Metab. 2004;287(3):E537–46.PubMedCrossRef Kashyap SR et al. Discordant effects of a chronic physiological increase in plasma FFA on insulin signaling in healthy subjects with or without a family history of type 2 diabetes. Am J Physiol Endocrinol Metab. 2004;287(3):E537–46.PubMedCrossRef
27.
go back to reference Goodpaster BH, Thaete FL, Kelley DE. Composition of skeletal muscle evaluated with computed tomography. Ann N Y Acad Sci. 2000;904:18–24.PubMedCrossRef Goodpaster BH, Thaete FL, Kelley DE. Composition of skeletal muscle evaluated with computed tomography. Ann N Y Acad Sci. 2000;904:18–24.PubMedCrossRef
28.
go back to reference Bittel AJ et al. Explanators of sarcopenia in individuals with diabesity: a cross-sectional analysis. J Geriatr Phys Ther. 2015 [Epub ahead of print]. Bittel AJ et al. Explanators of sarcopenia in individuals with diabesity: a cross-sectional analysis. J Geriatr Phys Ther. 2015 [Epub ahead of print].
29.
go back to reference Hilton TN et al. Excessive adipose tissue infiltration in skeletal muscle in individuals with obesity, diabetes mellitus, and peripheral neuropathy: association with performance and function. Phys Ther. 2008;88(11):1336–44.PubMedPubMedCentralCrossRef Hilton TN et al. Excessive adipose tissue infiltration in skeletal muscle in individuals with obesity, diabetes mellitus, and peripheral neuropathy: association with performance and function. Phys Ther. 2008;88(11):1336–44.PubMedPubMedCentralCrossRef
30.
go back to reference Tuttle LJ, Hastings MK, Mueller MJ. A moderate-intensity weight-bearing exercise program for a person with type 2 diabetes and peripheral neuropathy. Phys Ther. 2012;92(1):133–41.PubMedCrossRef Tuttle LJ, Hastings MK, Mueller MJ. A moderate-intensity weight-bearing exercise program for a person with type 2 diabetes and peripheral neuropathy. Phys Ther. 2012;92(1):133–41.PubMedCrossRef
31.
go back to reference Tuttle LJ et al. Lower physical activity is associated with higher intermuscular adipose tissue in people with type 2 diabetes and peripheral neuropathy. Phys Ther. 2011;91(6):923–30.PubMedPubMedCentralCrossRef Tuttle LJ et al. Lower physical activity is associated with higher intermuscular adipose tissue in people with type 2 diabetes and peripheral neuropathy. Phys Ther. 2011;91(6):923–30.PubMedPubMedCentralCrossRef
32.
go back to reference Sugimoto K, Yasujima M, Yagihashi S. Role of advanced glycation end products in diabetic neuropathy. Curr Pharm Des. 2008;14(10):953–61.PubMedCrossRef Sugimoto K, Yasujima M, Yagihashi S. Role of advanced glycation end products in diabetic neuropathy. Curr Pharm Des. 2008;14(10):953–61.PubMedCrossRef
33.
go back to reference Juranek JK et al. Increased expression of the receptor for advanced glycation end-products in human peripheral neuropathies. Brain Behav. 2013;3(6):701–9.PubMedPubMedCentralCrossRef Juranek JK et al. Increased expression of the receptor for advanced glycation end-products in human peripheral neuropathies. Brain Behav. 2013;3(6):701–9.PubMedPubMedCentralCrossRef
35.
36.
go back to reference Yoo M et al. Pilot study of exercise therapy on painful diabetic peripheral neuropathy. Pain Med. 2015;16(8):1482–9.PubMedCrossRef Yoo M et al. Pilot study of exercise therapy on painful diabetic peripheral neuropathy. Pain Med. 2015;16(8):1482–9.PubMedCrossRef
37.
39.
go back to reference Ziegler D et al. Near-normoglycaemia and development of neuropathy: a 24-year prospective study from diagnosis of type 1 diabetes. BMJ Open. 2015;5(6):e006559.PubMedPubMedCentralCrossRef Ziegler D et al. Near-normoglycaemia and development of neuropathy: a 24-year prospective study from diagnosis of type 1 diabetes. BMJ Open. 2015;5(6):e006559.PubMedPubMedCentralCrossRef
40.
go back to reference Kennedy JM, Zochodne DW. Impaired peripheral nerve regeneration in diabetes mellitus. J Peripher Nerv Syst. 2005;10(2):144–57.PubMedCrossRef Kennedy JM, Zochodne DW. Impaired peripheral nerve regeneration in diabetes mellitus. J Peripher Nerv Syst. 2005;10(2):144–57.PubMedCrossRef
41.
go back to reference Griffin JW, Thompson WJ. Biology and pathology of nonmyelinating Schwann cells. Glia. 2008;56(14):1518–31.PubMedCrossRef Griffin JW, Thompson WJ. Biology and pathology of nonmyelinating Schwann cells. Glia. 2008;56(14):1518–31.PubMedCrossRef
42.
go back to reference Tesfaye S et al. Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments. Diabetes Care. 2010;33(10):2285–93.PubMedPubMedCentralCrossRef Tesfaye S et al. Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments. Diabetes Care. 2010;33(10):2285–93.PubMedPubMedCentralCrossRef
43.
go back to reference Kaprio J et al. Concordance for type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland. Diabetologia. 1992;35(11):1060–7.PubMedCrossRef Kaprio J et al. Concordance for type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland. Diabetologia. 1992;35(11):1060–7.PubMedCrossRef
44.
go back to reference Groop L et al. Metabolic consequences of a family history of NIDDM (the Botnia study): evidence for sex-specific parental effects. Diabetes. 1996;45(11):1585–93.PubMedCrossRef Groop L et al. Metabolic consequences of a family history of NIDDM (the Botnia study): evidence for sex-specific parental effects. Diabetes. 1996;45(11):1585–93.PubMedCrossRef
47.
go back to reference Weinstein AR et al. Relationship of physical activity vs body mass index with type 2 diabetes in women. JAMA. 2004;292(10):1188–94.PubMedCrossRef Weinstein AR et al. Relationship of physical activity vs body mass index with type 2 diabetes in women. JAMA. 2004;292(10):1188–94.PubMedCrossRef
48.
49.
go back to reference Al-Kaabi, J, Maskari, FA, Zoubeidi, T, Abdulle, A, Shah, SM. Prevalence and determinants of peripheral neuropathy in patients with type 2 diabetes attending a tertiary care center in the United Arab Emirates. J Diabetes Metab, 2014;5(346). doi:10.4172/2155-6156.1000346. Al-Kaabi, J, Maskari, FA, Zoubeidi, T, Abdulle, A, Shah, SM. Prevalence and determinants of peripheral neuropathy in patients with type 2 diabetes attending a tertiary care center in the United Arab Emirates. J Diabetes Metab, 2014;5(346). doi:10.​4172/​2155-6156.​1000346.
50.
go back to reference Diabetes Prevention Program Research, G et al. 10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study. Lancet. 2009;374(9702):1677–86.CrossRef Diabetes Prevention Program Research, G et al. 10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study. Lancet. 2009;374(9702):1677–86.CrossRef
51.
go back to reference Tuomilehto J et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med. 2001;344(18):1343–50.PubMedCrossRef Tuomilehto J et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med. 2001;344(18):1343–50.PubMedCrossRef
52.
go back to reference Pan XR et al. Prevalence of diabetes and its risk factors in China, 1994. National Diabetes Prevention and Control Cooperative Group. Diabetes Care. 1997;20(11):1664–9.PubMedCrossRef Pan XR et al. Prevalence of diabetes and its risk factors in China, 1994. National Diabetes Prevention and Control Cooperative Group. Diabetes Care. 1997;20(11):1664–9.PubMedCrossRef
53.
go back to reference Balducci S et al. Exercise training can modify the natural history of diabetic peripheral neuropathy. J Diabetes Complications. 2006;20(4):216–23.PubMedCrossRef Balducci S et al. Exercise training can modify the natural history of diabetic peripheral neuropathy. J Diabetes Complications. 2006;20(4):216–23.PubMedCrossRef
54.
go back to reference Smith AG et al. Lifestyle intervention for pre-diabetic neuropathy. Diabetes Care. 2006;29(6):1294–9.PubMedCrossRef Smith AG et al. Lifestyle intervention for pre-diabetic neuropathy. Diabetes Care. 2006;29(6):1294–9.PubMedCrossRef
55.••
go back to reference Kluding PM et al. The effect of exercise on neuropathic symptoms, nerve function, and cutaneous innervation in people with diabetic peripheral neuropathy. J Diabetes Complications. 2012;26(5):424–9. Describes changes in neuropathic and cutaneous nerve fiber branching following exercise in persons with diabetic peripheral neuropathy. PubMedPubMedCentralCrossRef Kluding PM et al. The effect of exercise on neuropathic symptoms, nerve function, and cutaneous innervation in people with diabetic peripheral neuropathy. J Diabetes Complications. 2012;26(5):424–9. Describes changes in neuropathic and cutaneous nerve fiber branching following exercise in persons with diabetic peripheral neuropathy. PubMedPubMedCentralCrossRef
56.
go back to reference Morrison S et al. Exercise improves gait, reaction time and postural stability in older adults with type 2 diabetes and neuropathy. J Diabetes Complications. 2014;28(5):715–22.PubMedCrossRef Morrison S et al. Exercise improves gait, reaction time and postural stability in older adults with type 2 diabetes and neuropathy. J Diabetes Complications. 2014;28(5):715–22.PubMedCrossRef
57.••
go back to reference Dixit S, Maiya AG, Shastry BA. Effect of aerobic exercise on peripheral nerve functions of population with diabetic peripheral neuropathy in type 2 diabetes: a single blind, parallel group randomized controlled trial. J Diabetes Complications. 2014;28(3):332–9. Compares moderate intensity aerobic exercise and standard care on nerve conduction velocity and Michigan Diabetic Neuropathy Score. PubMedCrossRef Dixit S, Maiya AG, Shastry BA. Effect of aerobic exercise on peripheral nerve functions of population with diabetic peripheral neuropathy in type 2 diabetes: a single blind, parallel group randomized controlled trial. J Diabetes Complications. 2014;28(3):332–9. Compares moderate intensity aerobic exercise and standard care on nerve conduction velocity and Michigan Diabetic Neuropathy Score. PubMedCrossRef
58.
go back to reference Ahn S, Song R. Effects of Tai Chi exercise on glucose control, neuropathy scores, balance, and quality of life in patients with type 2 diabetes and neuropathy. J Altern Complement Med. 2012;18(12):1172–8.PubMedPubMedCentralCrossRef Ahn S, Song R. Effects of Tai Chi exercise on glucose control, neuropathy scores, balance, and quality of life in patients with type 2 diabetes and neuropathy. J Altern Complement Med. 2012;18(12):1172–8.PubMedPubMedCentralCrossRef
59.
go back to reference Healy GN et al. Objectively measured sedentary time, physical activity, and metabolic risk: the Australian Diabetes, Obesity and Lifestyle Study (AusDiab). Diabetes Care. 2008;31(2):369–71.PubMedCrossRef Healy GN et al. Objectively measured sedentary time, physical activity, and metabolic risk: the Australian Diabetes, Obesity and Lifestyle Study (AusDiab). Diabetes Care. 2008;31(2):369–71.PubMedCrossRef
60.
go back to reference Mueller MJ et al. Weight-bearing versus nonweight-bearing exercise for persons with diabetes and peripheral neuropathy: a randomized controlled trial. Arch Phys Med Rehabil. 2013;94(5):829–38.PubMedCrossRef Mueller MJ et al. Weight-bearing versus nonweight-bearing exercise for persons with diabetes and peripheral neuropathy: a randomized controlled trial. Arch Phys Med Rehabil. 2013;94(5):829–38.PubMedCrossRef
61.
go back to reference Lemaster JW et al. Daily weight-bearing activity does not increase the risk of diabetic foot ulcers. Med Sci Sports Exerc. 2003;35(7):1093–9.PubMedCrossRef Lemaster JW et al. Daily weight-bearing activity does not increase the risk of diabetic foot ulcers. Med Sci Sports Exerc. 2003;35(7):1093–9.PubMedCrossRef
62.
go back to reference Lemaster JW et al. Effect of weight-bearing activity on foot ulcer incidence in people with diabetic peripheral neuropathy: feet first randomized controlled trial. Phys Ther. 2008;88(11):1385–98.PubMedCrossRef Lemaster JW et al. Effect of weight-bearing activity on foot ulcer incidence in people with diabetic peripheral neuropathy: feet first randomized controlled trial. Phys Ther. 2008;88(11):1385–98.PubMedCrossRef
63.
go back to reference Mueller MJ, Maluf KS. Tissue adaptation to physical stress: a proposed “physical stress theory” to guide physical therapist practice, education, and research. Phys Ther. 2002;82(4):383–403.PubMed Mueller MJ, Maluf KS. Tissue adaptation to physical stress: a proposed “physical stress theory” to guide physical therapist practice, education, and research. Phys Ther. 2002;82(4):383–403.PubMed
64.
go back to reference Maluf KS, Mueller MJ. Novel Award 2002. Comparison of physical activity and cumulative plantar tissue stress among subjects with and without diabetes mellitus and a history of recurrent plantar ulcers. Clin Biomech (Bristol, Avon). 2003;18(7):567–75.CrossRef Maluf KS, Mueller MJ. Novel Award 2002. Comparison of physical activity and cumulative plantar tissue stress among subjects with and without diabetes mellitus and a history of recurrent plantar ulcers. Clin Biomech (Bristol, Avon). 2003;18(7):567–75.CrossRef
65.
go back to reference Armstrong DG et al. Variability in activity may precede diabetic foot ulceration. Diabetes Care. 2004;27(8):1980–4.PubMedCrossRef Armstrong DG et al. Variability in activity may precede diabetic foot ulceration. Diabetes Care. 2004;27(8):1980–4.PubMedCrossRef
66.
go back to reference Hu FB et al. Television watching and other sedentary behaviors in relation to risk of obesity and type 2 diabetes mellitus in women. JAMA. 2003;289(14):1785–91.PubMedCrossRef Hu FB et al. Television watching and other sedentary behaviors in relation to risk of obesity and type 2 diabetes mellitus in women. JAMA. 2003;289(14):1785–91.PubMedCrossRef
67.
go back to reference Barone Gibbs B et al. Reducing sedentary behavior versus increasing moderate-to-vigorous intensity physical activity in older adults: a 12-week randomized, clinical trial. J Aging Health. 2016 [Epub ahead of print]. Barone Gibbs B et al. Reducing sedentary behavior versus increasing moderate-to-vigorous intensity physical activity in older adults: a 12-week randomized, clinical trial. J Aging Health. 2016 [Epub ahead of print].
68.
go back to reference Boucher P et al. Postural stability in diabetic polyneuropathy. Diabetes Care. 1995;18(5):638–45.PubMedCrossRef Boucher P et al. Postural stability in diabetic polyneuropathy. Diabetes Care. 1995;18(5):638–45.PubMedCrossRef
69.
go back to reference Menz HB et al. Walking stability and sensorimotor function in older people with diabetic peripheral neuropathy. Arch Phys Med Rehabil. 2004;85(2):245–52.PubMedCrossRef Menz HB et al. Walking stability and sensorimotor function in older people with diabetic peripheral neuropathy. Arch Phys Med Rehabil. 2004;85(2):245–52.PubMedCrossRef
70.
go back to reference Pan X, Bai J. Balance training in the intervention of fall risk in elderly with diabetic peripheral neuropathy: a review. Int J Nurs Sci. 2014;1(4):441–5. Pan X, Bai J. Balance training in the intervention of fall risk in elderly with diabetic peripheral neuropathy: a review. Int J Nurs Sci. 2014;1(4):441–5.
71.
go back to reference Gregg EW et al. Diabetes and physical disability among older U.S. adults. Diabetes Care. 2000;23(9):1272–7.PubMedCrossRef Gregg EW et al. Diabetes and physical disability among older U.S. adults. Diabetes Care. 2000;23(9):1272–7.PubMedCrossRef
72.
go back to reference Miller DK et al. Reported and measured physical functioning in older inner-city diabetic African Americans. J Gerontol A Biol Sci Med Sci. 1999;54(5):M230–6.PubMedCrossRef Miller DK et al. Reported and measured physical functioning in older inner-city diabetic African Americans. J Gerontol A Biol Sci Med Sci. 1999;54(5):M230–6.PubMedCrossRef
73.
go back to reference DeMott TK et al. Falls and gait characteristics among older persons with peripheral neuropathy. Am J Phys Med Rehabil. 2007;86(2):125–32.PubMedCrossRef DeMott TK et al. Falls and gait characteristics among older persons with peripheral neuropathy. Am J Phys Med Rehabil. 2007;86(2):125–32.PubMedCrossRef
74.
go back to reference Cavanagh PR et al. Problems with gait and posture in neuropathic patients with insulin-dependent diabetes mellitus. Diabet Med. 1992;9(5):469–74.PubMedCrossRef Cavanagh PR et al. Problems with gait and posture in neuropathic patients with insulin-dependent diabetes mellitus. Diabet Med. 1992;9(5):469–74.PubMedCrossRef
75.
go back to reference Lee K, Lee S, Song C. Whole-body vibration training improves balance, muscle strength and glycosylated hemoglobin in elderly patients with diabetic neuropathy. Tohoku J Exp Med. 2013;231(4):305–14.PubMedCrossRef Lee K, Lee S, Song C. Whole-body vibration training improves balance, muscle strength and glycosylated hemoglobin in elderly patients with diabetic neuropathy. Tohoku J Exp Med. 2013;231(4):305–14.PubMedCrossRef
76.
go back to reference Akbari M et al. Do diabetic neuropathy patients benefit from balance training? J Rehabil Res Dev. 2012;49(2):333–8.PubMedCrossRef Akbari M et al. Do diabetic neuropathy patients benefit from balance training? J Rehabil Res Dev. 2012;49(2):333–8.PubMedCrossRef
77.
go back to reference Song CH et al. Effects of an exercise program on balance and trunk proprioception in older adults with diabetic neuropathies. Diabetes Technol Ther. 2011;13(8):803–11.PubMedCrossRef Song CH et al. Effects of an exercise program on balance and trunk proprioception in older adults with diabetic neuropathies. Diabetes Technol Ther. 2011;13(8):803–11.PubMedCrossRef
78.
go back to reference Allet L et al. The gait and balance of patients with diabetes can be improved: a randomised controlled trial. Diabetologia. 2010;53(3):458–66.PubMedCrossRef Allet L et al. The gait and balance of patients with diabetes can be improved: a randomised controlled trial. Diabetologia. 2010;53(3):458–66.PubMedCrossRef
79.
go back to reference Richardson JK, Sandman D, Vela S. A focused exercise regimen improves clinical measures of balance in patients with peripheral neuropathy. Arch Phys Med Rehabil. 2001;82(2):205–9.PubMedCrossRef Richardson JK, Sandman D, Vela S. A focused exercise regimen improves clinical measures of balance in patients with peripheral neuropathy. Arch Phys Med Rehabil. 2001;82(2):205–9.PubMedCrossRef
80.
go back to reference Kelley DE, Goodpaster BH. Effects of physical activity on insulin action and glucose tolerance in obesity. Med Sci Sports Exerc. 1999;31(11 Suppl):S619–23.PubMedCrossRef Kelley DE, Goodpaster BH. Effects of physical activity on insulin action and glucose tolerance in obesity. Med Sci Sports Exerc. 1999;31(11 Suppl):S619–23.PubMedCrossRef
82.
go back to reference Mandroukas K et al. Physical training in obese women. Effects of muscle morphology, biochemistry and function. Eur J Appl Physiol Occup Physiol. 1984;52(4):355–61.PubMedCrossRef Mandroukas K et al. Physical training in obese women. Effects of muscle morphology, biochemistry and function. Eur J Appl Physiol Occup Physiol. 1984;52(4):355–61.PubMedCrossRef
83.
go back to reference Adamopoulos S et al. Physical training reduces peripheral markers of inflammation in patients with chronic heart failure. Eur Heart J. 2001;22(9):791–7.PubMedCrossRef Adamopoulos S et al. Physical training reduces peripheral markers of inflammation in patients with chronic heart failure. Eur Heart J. 2001;22(9):791–7.PubMedCrossRef
84.
go back to reference Menshikova EV et al. Effects of exercise on mitochondrial content and function in aging human skeletal muscle. J Gerontol A Biol Sci Med Sci. 2006;61(6):534–40.PubMedPubMedCentralCrossRef Menshikova EV et al. Effects of exercise on mitochondrial content and function in aging human skeletal muscle. J Gerontol A Biol Sci Med Sci. 2006;61(6):534–40.PubMedPubMedCentralCrossRef
85.
go back to reference Talanian JL et al. Two weeks of high-intensity aerobic interval training increases the capacity for fat oxidation during exercise in women. J Appl Physiol (1985). 2007;102(4):1439–47.CrossRef Talanian JL et al. Two weeks of high-intensity aerobic interval training increases the capacity for fat oxidation during exercise in women. J Appl Physiol (1985). 2007;102(4):1439–47.CrossRef
86.
go back to reference Dunn AL, Trivedi MH, O’Neal HA. Physical activity dose–response effects on outcomes of depression and anxiety. Med Sci Sports Exerc. 2001;33(6 Suppl):S587–97. discussion 609–10.PubMedCrossRef Dunn AL, Trivedi MH, O’Neal HA. Physical activity dose–response effects on outcomes of depression and anxiety. Med Sci Sports Exerc. 2001;33(6 Suppl):S587–97. discussion 609–10.PubMedCrossRef
87.
go back to reference Salmon P. Effects of physical exercise on anxiety, depression, and sensitivity to stress: a unifying theory. Clin Psychol Rev. 2001;21(1):33–61.PubMedCrossRef Salmon P. Effects of physical exercise on anxiety, depression, and sensitivity to stress: a unifying theory. Clin Psychol Rev. 2001;21(1):33–61.PubMedCrossRef
89.
go back to reference Dunstan DW et al. Too much sitting—a health hazard. Diabetes Res Clin Pract. 2012;97(3):368–76.PubMedCrossRef Dunstan DW et al. Too much sitting—a health hazard. Diabetes Res Clin Pract. 2012;97(3):368–76.PubMedCrossRef
90.
go back to reference Beddhu S et al. Light-intensity physical activities and mortality in the United States general population and CKD subpopulation. Clin J Am Soc Nephrol. 2015;10(7):1145–53.PubMedPubMedCentralCrossRef Beddhu S et al. Light-intensity physical activities and mortality in the United States general population and CKD subpopulation. Clin J Am Soc Nephrol. 2015;10(7):1145–53.PubMedPubMedCentralCrossRef
91.
go back to reference Jelleyman C et al. The effects of high-intensity interval training on glucose regulation and insulin resistance: a meta-analysis. Obes Rev. 2015;16(11):942–61.PubMedCrossRef Jelleyman C et al. The effects of high-intensity interval training on glucose regulation and insulin resistance: a meta-analysis. Obes Rev. 2015;16(11):942–61.PubMedCrossRef
92.•
go back to reference Hamed N, Raoof N. Effect of high intensity interval training on diabetic obese women with polyneuropathy: a randomized controlled clinical trial. Phys Ther Rehabil. 2014;1(4):1. Compares high intensity interval training and moderate intensity aerobic exercise on pain and glucose tolerance in patients with polyneuropathy. Hamed N, Raoof N. Effect of high intensity interval training on diabetic obese women with polyneuropathy: a randomized controlled clinical trial. Phys Ther Rehabil. 2014;1(4):1. Compares high intensity interval training and moderate intensity aerobic exercise on pain and glucose tolerance in patients with polyneuropathy.
93.
go back to reference Little JP et al. Low-volume high-intensity interval training reduces hyperglycemia and increases muscle mitochondrial capacity in patients with type 2 diabetes. J Appl Physiol (1985). 2011;111(6):1554–60.CrossRef Little JP et al. Low-volume high-intensity interval training reduces hyperglycemia and increases muscle mitochondrial capacity in patients with type 2 diabetes. J Appl Physiol (1985). 2011;111(6):1554–60.CrossRef
94.
go back to reference Iellamo F et al. Matched dose interval and continuous exercise training induce similar cardiorespiratory and metabolic adaptations in patients with heart failure. Int J Cardiol. 2013;167(6):2561–5.PubMedCrossRef Iellamo F et al. Matched dose interval and continuous exercise training induce similar cardiorespiratory and metabolic adaptations in patients with heart failure. Int J Cardiol. 2013;167(6):2561–5.PubMedCrossRef
95.
go back to reference Fu TC et al. Aerobic interval training improves oxygen uptake efficiency by enhancing cerebral and muscular hemodynamics in patients with heart failure. Int J Cardiol. 2013;167(1):41–50.PubMedCrossRef Fu TC et al. Aerobic interval training improves oxygen uptake efficiency by enhancing cerebral and muscular hemodynamics in patients with heart failure. Int J Cardiol. 2013;167(1):41–50.PubMedCrossRef
96.
go back to reference Conraads VM et al. Aerobic interval training and continuous training equally improve aerobic exercise capacity in patients with coronary artery disease: the SAINTEX-CAD study. Int J Cardiol. 2015;179:203–10.PubMedCrossRef Conraads VM et al. Aerobic interval training and continuous training equally improve aerobic exercise capacity in patients with coronary artery disease: the SAINTEX-CAD study. Int J Cardiol. 2015;179:203–10.PubMedCrossRef
97.
go back to reference Sigal RJ et al. Physical activity/exercise and type 2 diabetes: a consensus statement from the American Diabetes Association. Diabetes Care. 2006;29(6):1433–8.PubMedCrossRef Sigal RJ et al. Physical activity/exercise and type 2 diabetes: a consensus statement from the American Diabetes Association. Diabetes Care. 2006;29(6):1433–8.PubMedCrossRef
98.•
go back to reference Kluding PM et al. Safety of aerobic exercise in people with diabetic peripheral neuropathy: single-group clinical trial. Phys Ther. 2015;95(2):223–34. Examines adverse events during moderate-intensity, supervised aerobic exercise in people with diabetic peripheral neuropathy. PubMedCrossRef Kluding PM et al. Safety of aerobic exercise in people with diabetic peripheral neuropathy: single-group clinical trial. Phys Ther. 2015;95(2):223–34. Examines adverse events during moderate-intensity, supervised aerobic exercise in people with diabetic peripheral neuropathy. PubMedCrossRef
Metadata
Title
Exercise in Type 2 Diabetic Peripheral Neuropathy
Authors
Arwen A. Fuller
J. Robinson Singleton
A. Gordon Smith
Robin L. Marcus
Publication date
01-09-2016
Publisher
Springer US
Published in
Current Geriatrics Reports / Issue 3/2016
Electronic ISSN: 2196-7865
DOI
https://doi.org/10.1007/s13670-016-0177-6

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