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Cancer Causes & Control
Published in: Cancer Causes & Control 12/2015

01-12-2015 | Original paper

Excess body weight and colorectal cancer survival: the multiethnic cohort

Authors: Gertraud Maskarinec, Brook E. Harmon, Melissa A. Little, Nicholas J. Ollberding, Laurence N. Kolonel, Brian E. Henderson, Loic Le Marchand, Lynne R. Wilkens

Published in: Cancer Causes & Control | Issue 12/2015

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Abstract

Purpose

Excess body weight is a risk factor for colorectal cancer (CRC) and may also adversely affect survival in CRC patients.

Methods

This study examined the relation of body mass index (BMI), which was self-reported at cohort entry and after 5.7 ± 0.8 years, with CRC-specific and all-cause survival among 4,204 incident cases of invasive CRC in the multiethnic cohort. Cox regression analysis with age as time metric and BMI as time-varying exposure was applied to estimate hazard ratios (HR) and 95 % confidence intervals (CIs) while adjusting for relevant covariates.

Results

Over 6.0 ± 4.7 years of follow-up, 1,976 all-cause and 1,095 CRC-specific deaths were recorded. The mean time interval between cohort entry and diagnosis was 7.6 ± 4.7 years. No association with CRC-specific survival was detected in men (HR5units = 0.94; 95 %CI 0.84–1.04) or women (HR5units = 0.98; 95 %CI 0.89–1.08). In men, all-cause survival also showed no relation with BMI (HR5unit = 0.97; 95 %CI 0.90–1.06), whereas it was reduced in women (HR5units = 1.10; 95 %CI 1.03–1.18). Interactions of BMI with ethnicity were only significant for obesity. Obese Latino and overweight Native Hawaiian men as well as overweight African-American women experienced significantly better CRC-specific survival than whites. Overweight Japanese men and African-American women had better all-cause survival and obese Latino women had the lowest all-cause survival (HRobese = 1.74; 95 %CI 1.08–2.80).

Conclusions

This analysis detected little evidence for an adverse effect of excess body weight on CRC-specific survival, but all-cause survival was reduced in women. These findings suggest that adiposity may be less important for CRC survival than as an etiologic factor.
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Metadata
Title
Excess body weight and colorectal cancer survival: the multiethnic cohort
Authors
Gertraud Maskarinec
Brook E. Harmon
Melissa A. Little
Nicholas J. Ollberding
Laurence N. Kolonel
Brian E. Henderson
Loic Le Marchand
Lynne R. Wilkens
Publication date
01-12-2015
Publisher
Springer International Publishing
Published in
Cancer Causes & Control / Issue 12/2015
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-015-0664-7

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