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Published in: Child's Nervous System 4/2024

19-12-2023 | Review

Evolution of neurosurgical advances and nuances in medulloblastoma therapy

Authors: Julian S. Rechberger, Erica A. Power, Michael DeCuypere, David J. Daniels

Published in: Child's Nervous System | Issue 4/2024

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Abstract

Medulloblastoma, the most common malignant brain tumor in children, presents a complex treatment challenge due to its propensity for infiltrative growth within the posterior fossa and its potential attachment to critical anatomical structures. Central to the management of medulloblastoma is the surgical resection of the tumor, which is a key determinant of patient prognosis. However, the extent of surgical resection (EOR), ranging from gross total resection (GTR) to subtotal resection (STR) or even biopsy, has been the subject of extensive debate and investigation within the medical community. Today, the impact of neurosurgical EOR on the prognosis of medulloblastoma patients remains a complex and evolving area of investigation. The conflicting findings in the literature, the challenges posed by critical surrounding anatomical structures, the potential for surgical complications and neurologic morbidity, and the nuanced interactions with molecular subgroups all contribute to the complexity of this issue. As the field continues to advance, the imperative to strike a delicate balance between maximizing resection and preserving quality of life remains central to the management of medulloblastoma patients.
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Metadata
Title
Evolution of neurosurgical advances and nuances in medulloblastoma therapy
Authors
Julian S. Rechberger
Erica A. Power
Michael DeCuypere
David J. Daniels
Publication date
19-12-2023
Publisher
Springer Berlin Heidelberg
Published in
Child's Nervous System / Issue 4/2024
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-023-06239-x

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