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Open Access 01-12-2006 | Research article

Evidence for association between the HLA-DQA locus and abdominal aortic aneurysms in the Belgian population: a case control study

Authors: Toru Ogata, Lucie Gregoire, Katrina AB Goddard, Magdalena Skunca, Gerard Tromp, Wayne D Lancaster, Antonio R Parrado, Qing Lu, Hidenori Shibamura, Natzi Sakalihasan, Raymond Limet, Gerald L MacKean, Claudette Arthur, Taijiro Sueda, Helena Kuivaniemi

Published in: BMC Medical Genetics | Issue 1/2006

Abstract

Background

Chronic inflammation and autoimmunity likely contribute to the pathogenesis of abdominal aortic aneurysms (AAAs). The aim of this study was to investigate the role of autoimmunity in the etiology of AAAs using a genetic association study approach with HLA polymorphisms.

Methods

HLA-DQA1, -DQB1, -DRB1 and -DRB3-5 alleles were determined in 387 AAA cases (180 Belgian and 207 Canadian) and 426 controls (269 Belgian and 157 Canadian) by a PCR and single-strand oligonucleotide probe hybridization assay.

Results

We observed a potential association with the HLA-DQA1 locus among Belgian males (empirical p = 0.027, asymptotic p = 0.071). Specifically, there was a significant difference in the HLA-DQA1*0102 allele frequencies between AAA cases (67/322 alleles, 20.8%) and controls (44/356 alleles, 12.4%) in Belgian males (empirical p = 0.019, asymptotic p = 0.003). In haplotype analyses, marginally significant association was found between AAA and haplotype HLA-DQA1-DRB1 (p = 0.049 with global score statistics and p = 0.002 with haplotype-specific score statistics).

Conclusion

This study showed potential evidence that the HLA-DQA1 locus harbors a genetic risk factor for AAAs suggesting that autoimmunity plays a role in the pathogenesis of AAAs.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2350/7/67/prepub

Title: Evidence for association between the HLA-DQA locus and abdominal aortic aneurysms in the Belgian population: a case control study
Authors: Toru Ogata
Lucie Gregoire
Katrina AB Goddard
Magdalena Skunca
Gerard Tromp
Wayne D Lancaster
Antonio R Parrado
Qing Lu
Hidenori Shibamura
Natzi Sakalihasan
Raymond Limet
Gerald L MacKean
Claudette Arthur
Taijiro Sueda
Helena Kuivaniemi
Publication date: 01-12-2006
Publisher: BioMed Central
Published in: BMC Medical Genetics / Issue 1/2006
Electronic ISSN: 1471-2350
DOI: https://doi.org/10.1186/1471-2350-7-67

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Evidence for association between the HLA-DQA locus and abdominal aortic aneurysms in the Belgian population: a case control study

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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