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Published in: Current Osteoporosis Reports 2/2014

01-06-2014 | Nutrition, Exercise, and Lifestyle in Osteoporosis (C Weaver and S Ferrari, Section Editors)

Evidence for an Interaction Between Exercise and Nutrition for Improving Bone and Muscle Health

Authors: Robin M. Daly, Rachel L. Duckham, Jenny Gianoudis

Published in: Current Osteoporosis Reports | Issue 2/2014

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Abstract

Regular exercise and adequate nutrition, particularly dietary calcium, vitamin D, and protein, are prescribed as strategies to optimize peak bone mass and maintain bone and muscle health throughout life. Although the mechanism of action of exercise and nutrition on bone and muscle health are different—exercise has a site-specific modifying effect, whereas nutrition has a permissive generalized effect—there is evidence that combining calcium (or calcium rich dairy foods) or dietary protein with exercise can have a synergetic effect on bone mass and muscle health, respectively. However, many questions still remain as to whether there is a threshold level for these nutrients to optimize the exercise-induced gains. Further studies are also needed to investigate whether other dietary factors, such as vitamin D, soy isoflavones or omega-3 fatty acids, or a multinutrient supplement, can enhance the effects of exercise on bone and muscle health.
Literature
1.
go back to reference Bijlsma AY, Meskers CGM, Westendorp RGJ, et al. Chronology of age-related disease definitions: osteoporosis and sarcopenia. Ageing Res Rev. 2012;11(2):320–4.PubMedCrossRef Bijlsma AY, Meskers CGM, Westendorp RGJ, et al. Chronology of age-related disease definitions: osteoporosis and sarcopenia. Ageing Res Rev. 2012;11(2):320–4.PubMedCrossRef
2.
go back to reference Binkley N, Buehring B. Beyond FRAX: it’s time to consider “sarco-osteopenia.”. J Clin Densitom. 2009;12(4):413–6.PubMedCrossRef Binkley N, Buehring B. Beyond FRAX: it’s time to consider “sarco-osteopenia.”. J Clin Densitom. 2009;12(4):413–6.PubMedCrossRef
3.
go back to reference Cruz-Jentoft AJ, Baeyens JP, Bauer JM, et al. Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People. Age Ageing. 2010;39(4):412–23.PubMedCentralPubMedCrossRef Cruz-Jentoft AJ, Baeyens JP, Bauer JM, et al. Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People. Age Ageing. 2010;39(4):412–23.PubMedCentralPubMedCrossRef
4.
go back to reference Sirola J, Kroger H. Similarities in acquired factors related to postmenopausal osteoporosis and sarcopenia. J Osteoporos. 2011;2011:536735.PubMedCentralPubMed Sirola J, Kroger H. Similarities in acquired factors related to postmenopausal osteoporosis and sarcopenia. J Osteoporos. 2011;2011:536735.PubMedCentralPubMed
5.
go back to reference Specker B, Vukovich M. Evidence for an interaction between exercise and nutrition for improved bone health during growth. Med Sport Sci. 2007;51:50–63.PubMedCrossRef Specker B, Vukovich M. Evidence for an interaction between exercise and nutrition for improved bone health during growth. Med Sport Sci. 2007;51:50–63.PubMedCrossRef
6.
go back to reference Koopman R, Saris WH, Wagenmakers AJ, et al. Nutritional interventions to promote post-exercise muscle protein synthesis. Sports Med. 2007;37(10):895–906.PubMedCrossRef Koopman R, Saris WH, Wagenmakers AJ, et al. Nutritional interventions to promote post-exercise muscle protein synthesis. Sports Med. 2007;37(10):895–906.PubMedCrossRef
7.
go back to reference Daly RM. Independent and combined effects of exercise and vitamin d on muscle morphology, function and falls in the elderly. Nutrients. 2010;2(9):1005–17.PubMedCentralPubMedCrossRef Daly RM. Independent and combined effects of exercise and vitamin d on muscle morphology, function and falls in the elderly. Nutrients. 2010;2(9):1005–17.PubMedCentralPubMedCrossRef
8.
go back to reference Iuliano-Burns S, Saxon L, Naughton G, et al. Regional specificity of exercise and calcium during skeletal growth in girls: a randomized controlled trial. J Bone Miner Res. 2003;18(1):156–62.PubMedCrossRef Iuliano-Burns S, Saxon L, Naughton G, et al. Regional specificity of exercise and calcium during skeletal growth in girls: a randomized controlled trial. J Bone Miner Res. 2003;18(1):156–62.PubMedCrossRef
9.
go back to reference Bass SL, Naughton G, Saxon L, et al. Exercise and calcium combined results in a greater osteogenic effect than either factor alone: a blinded randomized placebo-controlled trial in boys. J Bone Miner Res. 2007;22(3):458–64.PubMedCrossRef Bass SL, Naughton G, Saxon L, et al. Exercise and calcium combined results in a greater osteogenic effect than either factor alone: a blinded randomized placebo-controlled trial in boys. J Bone Miner Res. 2007;22(3):458–64.PubMedCrossRef
10.
go back to reference Aoe S, Toba Y, Yamamura J, et al. Controlled trial of the effects of milk basic protein (MBP) supplementation on bone metabolism in healthy adult women. Biosci Biotechnol Biochem. 2001;65(4):913–8.PubMedCrossRef Aoe S, Toba Y, Yamamura J, et al. Controlled trial of the effects of milk basic protein (MBP) supplementation on bone metabolism in healthy adult women. Biosci Biotechnol Biochem. 2001;65(4):913–8.PubMedCrossRef
11.
go back to reference Toba Y, Takada Y, Matsuoka Y, et al. Milk basic protein promotes bone formation and suppresses bone resorption in healthy adult men. Biosci Biotechnol Biochem. 2001;65(6):1353–7.PubMedCrossRef Toba Y, Takada Y, Matsuoka Y, et al. Milk basic protein promotes bone formation and suppresses bone resorption in healthy adult men. Biosci Biotechnol Biochem. 2001;65(6):1353–7.PubMedCrossRef
12.
go back to reference Specker B, Binkley T. Randomized trial of physical activity and calcium supplementation on bone mineral content in 3- to 5-year-old children. J Bone Miner Res. 2003;18(5):885–92.PubMedCrossRef Specker B, Binkley T. Randomized trial of physical activity and calcium supplementation on bone mineral content in 3- to 5-year-old children. J Bone Miner Res. 2003;18(5):885–92.PubMedCrossRef
13.
go back to reference Stear SJ, Prentice A, Jones SC, et al. Effect of a calcium and exercise intervention on the bone mineral status of 16-18-y-old adolescent girls. Am J Clin Nutr. 2003;77(4):985–92.PubMed Stear SJ, Prentice A, Jones SC, et al. Effect of a calcium and exercise intervention on the bone mineral status of 16-18-y-old adolescent girls. Am J Clin Nutr. 2003;77(4):985–92.PubMed
14.
go back to reference Specker BL. Evidence for an interaction between calcium intake and physical activity on changes in bone mineral density. J Bone Miner Res. 1996;11(10):1539–44.PubMedCrossRef Specker BL. Evidence for an interaction between calcium intake and physical activity on changes in bone mineral density. J Bone Miner Res. 1996;11(10):1539–44.PubMedCrossRef
15.
go back to reference Kelley GA. Aerobic exercise and bone density at the hip in postmenopausal women: a meta-analysis. Prev Med. 1998;27(6):798–807.PubMedCrossRef Kelley GA. Aerobic exercise and bone density at the hip in postmenopausal women: a meta-analysis. Prev Med. 1998;27(6):798–807.PubMedCrossRef
16.
go back to reference Devine A, Dhaliwal SS, Dick IM, et al. Physical activity and calcium consumption are important determinants of lower limb bone mass in older women. J Bone Miner Res. 2004;19(10):1634–9.PubMedCrossRef Devine A, Dhaliwal SS, Dick IM, et al. Physical activity and calcium consumption are important determinants of lower limb bone mass in older women. J Bone Miner Res. 2004;19(10):1634–9.PubMedCrossRef
17.
go back to reference Nurzenski MK, Briffa NK, Price RI, et al. Geometric indices of bone strength are associated with physical activity and dietary calcium intake in healthy older women. J Bone Miner Res. 2007;22(3):416–24.PubMedCrossRef Nurzenski MK, Briffa NK, Price RI, et al. Geometric indices of bone strength are associated with physical activity and dietary calcium intake in healthy older women. J Bone Miner Res. 2007;22(3):416–24.PubMedCrossRef
18.
go back to reference Uusi-Rasi K, Sievanen H, Pasanen M, et al. Influence of calcium intake and physical activity on proximal femur bone mass and structure among pre- and postmenopausal women. A 10-year prospective study. Calcif Tissue Int. 2008;82(3):171–81.PubMedCrossRef Uusi-Rasi K, Sievanen H, Pasanen M, et al. Influence of calcium intake and physical activity on proximal femur bone mass and structure among pre- and postmenopausal women. A 10-year prospective study. Calcif Tissue Int. 2008;82(3):171–81.PubMedCrossRef
19.
go back to reference Uusi-Rasi K, Sievanen H, Pasanen M, et al. Associations of calcium intake and physical activity with bone density and size in premenopausal and postmenopausal women: a peripheral quantitative computed tomography study. J Bone Miner Res. 2002;17(3):544–52.PubMedCrossRef Uusi-Rasi K, Sievanen H, Pasanen M, et al. Associations of calcium intake and physical activity with bone density and size in premenopausal and postmenopausal women: a peripheral quantitative computed tomography study. J Bone Miner Res. 2002;17(3):544–52.PubMedCrossRef
20.
go back to reference Uusi-Rasi K, Sievanen H, Vuori I, et al. Associations of physical activity and calcium intake with bone mass and size in healthy women at different ages. J Bone Miner Res. 1998;13(1):133–42.PubMedCrossRef Uusi-Rasi K, Sievanen H, Vuori I, et al. Associations of physical activity and calcium intake with bone mass and size in healthy women at different ages. J Bone Miner Res. 1998;13(1):133–42.PubMedCrossRef
21.
go back to reference Lau EM, Woo J, Leung PC, et al. The effects of calcium supplementation and exercise on bone density in elderly Chinese women. Osteoporos Int. 1992;2(4):168–73.PubMedCrossRef Lau EM, Woo J, Leung PC, et al. The effects of calcium supplementation and exercise on bone density in elderly Chinese women. Osteoporos Int. 1992;2(4):168–73.PubMedCrossRef
22.
go back to reference Prince R, Devine A, Dick I, et al. The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women. J Bone Miner Res. 1995;10(7):1068–75.PubMedCrossRef Prince R, Devine A, Dick I, et al. The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women. J Bone Miner Res. 1995;10(7):1068–75.PubMedCrossRef
23.
go back to reference Prince RL, Smith M, Dick IM, et al. Prevention of postmenopausal osteoporosis. A comparative study of exercise, calcium supplementation, and hormone-replacement therapy. N Engl J Med. 1991;325(17):1189–95.PubMedCrossRef Prince RL, Smith M, Dick IM, et al. Prevention of postmenopausal osteoporosis. A comparative study of exercise, calcium supplementation, and hormone-replacement therapy. N Engl J Med. 1991;325(17):1189–95.PubMedCrossRef
24.
go back to reference Lanyon LE, Rubin CT, Baust G. Modulation of bone loss during calcium insufficiency by controlled dynamic loading. Calcif Tissue Int. 1986;38(4):209–16.PubMedCrossRef Lanyon LE, Rubin CT, Baust G. Modulation of bone loss during calcium insufficiency by controlled dynamic loading. Calcif Tissue Int. 1986;38(4):209–16.PubMedCrossRef
25.
go back to reference Girgis CM, Clifton-Bligh RJ, Hamrick MW, et al. The roles of vitamin D in skeletal muscle: form, function, and metabolism. Endocr Rev. 2013;34(1):33–83.PubMedCrossRef Girgis CM, Clifton-Bligh RJ, Hamrick MW, et al. The roles of vitamin D in skeletal muscle: form, function, and metabolism. Endocr Rev. 2013;34(1):33–83.PubMedCrossRef
26.
go back to reference Bischoff-Ferrari HA, Willett WC, Orav EJ, et al. A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med. 2012;367(1):40–9.PubMedCrossRef Bischoff-Ferrari HA, Willett WC, Orav EJ, et al. A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med. 2012;367(1):40–9.PubMedCrossRef
27.
go back to reference Tang BM, Eslick GD, Nowson C, et al. Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis. Lancet. 2007;370(9588):657–66.PubMedCrossRef Tang BM, Eslick GD, Nowson C, et al. Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis. Lancet. 2007;370(9588):657–66.PubMedCrossRef
28.
go back to reference Bischoff-Ferrari HA, Dawson-Hughes B, Staehelin HB, et al. Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials. BMJ. 2009;339:b3692.PubMedCentralPubMedCrossRef Bischoff-Ferrari HA, Dawson-Hughes B, Staehelin HB, et al. Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials. BMJ. 2009;339:b3692.PubMedCentralPubMedCrossRef
29.
go back to reference Bunout D, Barrera G, Leiva L, et al. Effects of vitamin D supplementation and exercise training on physical performance in Chilean vitamin D deficient elderly subjects. Exp Geront. 2006;41(8):746–52.CrossRef Bunout D, Barrera G, Leiva L, et al. Effects of vitamin D supplementation and exercise training on physical performance in Chilean vitamin D deficient elderly subjects. Exp Geront. 2006;41(8):746–52.CrossRef
30.
go back to reference Kukuljan S, Nowson CA, Bass SL, et al. Effects of a multi-component exercise program and calcium-vitamin-D3-fortified milk on bone mineral density in older men: a randomised controlled trial. Osteoporos Int. 2009;20(7):1241–51.PubMedCrossRef Kukuljan S, Nowson CA, Bass SL, et al. Effects of a multi-component exercise program and calcium-vitamin-D3-fortified milk on bone mineral density in older men: a randomised controlled trial. Osteoporos Int. 2009;20(7):1241–51.PubMedCrossRef
31.••
go back to reference Kukuljan S, Nowson CA, Sanders KM, et al. Independent and combined effects of calcium-vitamin D3 and exercise on bone structure and strength in older men: an 18-month factorial design randomized controlled trial. J Clin Endocrinol Metab. 2011;96(4):955–63. This study demonstrates that a multi-modal exercise program incorporating resistance training and weight-bearing impact exercises enhanced bone health in older men, but providing additional calcium-Vitamin D to these replete men did not enhance the osteogenic response.PubMedCrossRef Kukuljan S, Nowson CA, Sanders KM, et al. Independent and combined effects of calcium-vitamin D3 and exercise on bone structure and strength in older men: an 18-month factorial design randomized controlled trial. J Clin Endocrinol Metab. 2011;96(4):955–63. This study demonstrates that a multi-modal exercise program incorporating resistance training and weight-bearing impact exercises enhanced bone health in older men, but providing additional calcium-Vitamin D to these replete men did not enhance the osteogenic response.PubMedCrossRef
32.
go back to reference Kukuljan S, Nowson CA, Sanders K, et al. Effects of resistance exercise and fortified milk on skeletal muscle mass, muscle size, and functional performance in middle-aged and older men: an 18-mo randomized controlled trial. J Appl Physiol (1985). 2009;107(6):1864–73.CrossRef Kukuljan S, Nowson CA, Sanders K, et al. Effects of resistance exercise and fortified milk on skeletal muscle mass, muscle size, and functional performance in middle-aged and older men: an 18-mo randomized controlled trial. J Appl Physiol (1985). 2009;107(6):1864–73.CrossRef
33.
go back to reference Verschueren SM, Bogaerts A, Delecluse C, et al. The effects of whole-body vibration training and vitamin D supplementation on muscle strength, muscle mass, and bone density in institutionalized elderly women: a 6-month randomized, controlled trial. J Bone Miner Res. 2011;26(1):42–9.PubMedCrossRef Verschueren SM, Bogaerts A, Delecluse C, et al. The effects of whole-body vibration training and vitamin D supplementation on muscle strength, muscle mass, and bone density in institutionalized elderly women: a 6-month randomized, controlled trial. J Bone Miner Res. 2011;26(1):42–9.PubMedCrossRef
34.••
go back to reference Bischoff-Ferrari HA, Dawson-Hughes B, Platz A, et al. Effect of high-dosage cholecalciferol and extended physiotherapy on complications after hip fracture: a randomized controlled trial. Arch Int Med. 2010;170(9):813–20. This factorial design trial in patients with acute hip fracture demonstrated that an extended physiotherapy program reduced falls and treatment with 2000 IU vitamin D reduced hospital re-admissions, but there was no synergetic interaction between the 2 therapies.CrossRef Bischoff-Ferrari HA, Dawson-Hughes B, Platz A, et al. Effect of high-dosage cholecalciferol and extended physiotherapy on complications after hip fracture: a randomized controlled trial. Arch Int Med. 2010;170(9):813–20. This factorial design trial in patients with acute hip fracture demonstrated that an extended physiotherapy program reduced falls and treatment with 2000 IU vitamin D reduced hospital re-admissions, but there was no synergetic interaction between the 2 therapies.CrossRef
35.
go back to reference Kerstetter JE, Allen LH. Dietary protein increases urinary calcium. J Nutr. 1990;120(1):134–6.PubMed Kerstetter JE, Allen LH. Dietary protein increases urinary calcium. J Nutr. 1990;120(1):134–6.PubMed
36.
go back to reference Darling AL, Millward DJ, Torgerson DJ, et al. Dietary protein and bone health: a systematic review and meta-analysis. Am J Clin Nutr. 2009;90(6):1674–92.PubMedCrossRef Darling AL, Millward DJ, Torgerson DJ, et al. Dietary protein and bone health: a systematic review and meta-analysis. Am J Clin Nutr. 2009;90(6):1674–92.PubMedCrossRef
37.
go back to reference Mangano KM, Sahni S, Kerstetter JE. Dietary protein is beneficial to bone health under conditions of adequate calcium intake: an update on clinical research. Curr Opin Clin Nutr Metab Care. 2014;17(1):69–74.PubMed Mangano KM, Sahni S, Kerstetter JE. Dietary protein is beneficial to bone health under conditions of adequate calcium intake: an update on clinical research. Curr Opin Clin Nutr Metab Care. 2014;17(1):69–74.PubMed
38.
go back to reference Calvez J, Poupin N, Chesneau C, et al. Protein intake, calcium balance and health consequences. Eur J Clin Nutr. 2012;66(3):281–95.PubMedCrossRef Calvez J, Poupin N, Chesneau C, et al. Protein intake, calcium balance and health consequences. Eur J Clin Nutr. 2012;66(3):281–95.PubMedCrossRef
39.
go back to reference Breen L, Phillips SM. Nutrient interaction for optimal protein anabolism in resistance exercise. Curr Opin Clin Nutr Metab Care. 2012;15(3):226–32.PubMedCrossRef Breen L, Phillips SM. Nutrient interaction for optimal protein anabolism in resistance exercise. Curr Opin Clin Nutr Metab Care. 2012;15(3):226–32.PubMedCrossRef
40.•
go back to reference Cermak NM, Res PT, de Groot LC, et al. Protein supplementation augments the adaptive response of skeletal muscle to resistance-type exercise training: a meta-analysis. Am J Clin Nutr. 2012;96(6):1454–64. This meta-analysis provides further evidence that combining protein supplementation with resistance exercise training can enhance muscle mass and strength in young and older adults compared with resistance training alone.PubMedCrossRef Cermak NM, Res PT, de Groot LC, et al. Protein supplementation augments the adaptive response of skeletal muscle to resistance-type exercise training: a meta-analysis. Am J Clin Nutr. 2012;96(6):1454–64. This meta-analysis provides further evidence that combining protein supplementation with resistance exercise training can enhance muscle mass and strength in young and older adults compared with resistance training alone.PubMedCrossRef
41.
go back to reference Chevalley T, Bonjour JP, Ferrari S, et al. High-protein intake enhances the positive impact of physical activity on BMC in prepubertal boys. J Bone Miner Res. 2008;23(1):131–42.PubMedCrossRef Chevalley T, Bonjour JP, Ferrari S, et al. High-protein intake enhances the positive impact of physical activity on BMC in prepubertal boys. J Bone Miner Res. 2008;23(1):131–42.PubMedCrossRef
42.
go back to reference Ballard TL, Clapper JA, Specker BL, et al. Effect of protein supplementation during a 6-mo strength and conditioning program on insulin-like growth factor I and markers of bone turnover in young adults. Am J Clin Nutr. 2005;81(6):1442–8.PubMed Ballard TL, Clapper JA, Specker BL, et al. Effect of protein supplementation during a 6-mo strength and conditioning program on insulin-like growth factor I and markers of bone turnover in young adults. Am J Clin Nutr. 2005;81(6):1442–8.PubMed
43.
go back to reference Ballard TL, Specker BL, Binkley TL, et al. Effect of protein supplementation during a 6-month strength and conditioning program on areal and volumetric bone parameters. Bone. 2006;38(6):898–904.PubMedCrossRef Ballard TL, Specker BL, Binkley TL, et al. Effect of protein supplementation during a 6-month strength and conditioning program on areal and volumetric bone parameters. Bone. 2006;38(6):898–904.PubMedCrossRef
44.
go back to reference Holm L, Olesen JL, Matsumoto K, et al. Protein-containing nutrient supplementation following strength training enhances the effect on muscle mass, strength, and bone formation in postmenopausal women. J Appl Physiol (1985). 2008;105(1):274–81.CrossRef Holm L, Olesen JL, Matsumoto K, et al. Protein-containing nutrient supplementation following strength training enhances the effect on muscle mass, strength, and bone formation in postmenopausal women. J Appl Physiol (1985). 2008;105(1):274–81.CrossRef
45.
go back to reference Umland EM, Cauffield JS, Kirk JK, et al. Phytoestrogens as therapeutic alternatives to traditional hormone replacement in postmenopausal women. Pharmacotherapy. 2000;20(8):981–90.PubMedCrossRef Umland EM, Cauffield JS, Kirk JK, et al. Phytoestrogens as therapeutic alternatives to traditional hormone replacement in postmenopausal women. Pharmacotherapy. 2000;20(8):981–90.PubMedCrossRef
46.•
go back to reference Chilibeck PD, Vatanparast H, Pierson R, et al. Effect of exercise training combined with isoflavone supplementation on bone and lipids in postmenopausal women: a randomized clinical trial. J Bone Miner Res. 2013;28(4):780–93. This large-scale 2-year intervention demonstrated that isoflavone supplementation combined with exercise did not enhance bone health in postmenopausal women, and in fact combining the 2 therapies may have an adverse effect on bone.PubMedCrossRef Chilibeck PD, Vatanparast H, Pierson R, et al. Effect of exercise training combined with isoflavone supplementation on bone and lipids in postmenopausal women: a randomized clinical trial. J Bone Miner Res. 2013;28(4):780–93. This large-scale 2-year intervention demonstrated that isoflavone supplementation combined with exercise did not enhance bone health in postmenopausal women, and in fact combining the 2 therapies may have an adverse effect on bone.PubMedCrossRef
47.
go back to reference Choquette S, Riesco E, Cormier E, et al. Effects of soya isoflavones and exercise on body composition and clinical risk factors of cardiovascular diseases in overweight postmenopausal women: a 6-month double-blind controlled trial. Br J Nutr. 2011;105(8):1199–209.PubMedCrossRef Choquette S, Riesco E, Cormier E, et al. Effects of soya isoflavones and exercise on body composition and clinical risk factors of cardiovascular diseases in overweight postmenopausal women: a 6-month double-blind controlled trial. Br J Nutr. 2011;105(8):1199–209.PubMedCrossRef
48.
go back to reference Evans EM, Racette SB, Van Pelt RE, et al. Effects of soy protein isolate and moderate exercise on bone turnover and bone mineral density in postmenopausal women. Menopause. 2007;14(3 Pt 1):481–8.PubMedCentralPubMedCrossRef Evans EM, Racette SB, Van Pelt RE, et al. Effects of soy protein isolate and moderate exercise on bone turnover and bone mineral density in postmenopausal women. Menopause. 2007;14(3 Pt 1):481–8.PubMedCentralPubMedCrossRef
49.
go back to reference Wu J, Oka J, Tabata I, et al. Effects of isoflavone and exercise on BMD and fat mass in postmenopausal Japanese women: a 1-year randomized placebo-controlled trial. J Bone Miner Res. 2006;21(5):780–9.PubMedCrossRef Wu J, Oka J, Tabata I, et al. Effects of isoflavone and exercise on BMD and fat mass in postmenopausal Japanese women: a 1-year randomized placebo-controlled trial. J Bone Miner Res. 2006;21(5):780–9.PubMedCrossRef
50.
go back to reference Calder PC, Ahluwalia N, Brouns F, et al. Dietary factors and low-grade inflammation in relation to overweight and obesity. Br J Nutr. 2011;106 Suppl 3:S5–78.PubMedCrossRef Calder PC, Ahluwalia N, Brouns F, et al. Dietary factors and low-grade inflammation in relation to overweight and obesity. Br J Nutr. 2011;106 Suppl 3:S5–78.PubMedCrossRef
51.
go back to reference Kruger MC, Horrobin DF. Calcium metabolism, osteoporosis and essential fatty acids: a review. Prog Lipid Res. 1997;36(2–3):131–51.PubMedCrossRef Kruger MC, Horrobin DF. Calcium metabolism, osteoporosis and essential fatty acids: a review. Prog Lipid Res. 1997;36(2–3):131–51.PubMedCrossRef
52.•
go back to reference Barbour KE, Boudreau R, Danielson ME, et al. Inflammatory markers and the risk of hip fracture: the Women’s Health Initiative. J Bone Miner Res. 2012;27(5):1167–76. This nested case control prospective study is one of the first to demonstrate that an increase in inflammatory markers is associated with an increased risk of hip fracture in older women.PubMedCentralPubMedCrossRef Barbour KE, Boudreau R, Danielson ME, et al. Inflammatory markers and the risk of hip fracture: the Women’s Health Initiative. J Bone Miner Res. 2012;27(5):1167–76. This nested case control prospective study is one of the first to demonstrate that an increase in inflammatory markers is associated with an increased risk of hip fracture in older women.PubMedCentralPubMedCrossRef
53.
go back to reference Ding C, Parameswaran V, Udayan R, et al. Circulating levels of inflammatory markers predict change in bone mineral density and resorption in older adults: a longitudinal study. J Clin Endocrinol Metab. 2008;93(5):1952–8.PubMedCrossRef Ding C, Parameswaran V, Udayan R, et al. Circulating levels of inflammatory markers predict change in bone mineral density and resorption in older adults: a longitudinal study. J Clin Endocrinol Metab. 2008;93(5):1952–8.PubMedCrossRef
54.
go back to reference Schaap LA, Pluijm SM, Deeg DJ, et al. Higher inflammatory marker levels in older persons: associations with 5-year change in muscle mass and muscle strength. J Gerontol A Biol Sci Med Sci. 2009;64(11):1183–9.PubMedCrossRef Schaap LA, Pluijm SM, Deeg DJ, et al. Higher inflammatory marker levels in older persons: associations with 5-year change in muscle mass and muscle strength. J Gerontol A Biol Sci Med Sci. 2009;64(11):1183–9.PubMedCrossRef
55.
go back to reference Verghese J, Holtzer R, Oh-Park M, et al. Inflammatory markers and gait speed decline in older adults. J Gerontol A Biol Sci Med Sci. 2011;66(10):1083–9.PubMedCrossRef Verghese J, Holtzer R, Oh-Park M, et al. Inflammatory markers and gait speed decline in older adults. J Gerontol A Biol Sci Med Sci. 2011;66(10):1083–9.PubMedCrossRef
57.
go back to reference Petersen AM, Pedersen BK. The anti-inflammatory effect of exercise. J Appl Physiol. 2005;98(4):1154–62.PubMedCrossRef Petersen AM, Pedersen BK. The anti-inflammatory effect of exercise. J Appl Physiol. 2005;98(4):1154–62.PubMedCrossRef
58.
go back to reference Tartibian B, Hajizadeh Maleki B, Kanaley J, et al. Long-term aerobic exercise and omega-3 supplementation modulate osteoporosis through inflammatory mechanisms in post-menopausal women: a randomized, repeated measures study. Nutr Metab. 2011;8:71.CrossRef Tartibian B, Hajizadeh Maleki B, Kanaley J, et al. Long-term aerobic exercise and omega-3 supplementation modulate osteoporosis through inflammatory mechanisms in post-menopausal women: a randomized, repeated measures study. Nutr Metab. 2011;8:71.CrossRef
59.
go back to reference Tartibian B, Maleki BH, Abbasi A. The calciotropic hormone response to omega-3 supple-mentation during long-term weight-bearing exercise training in postmenopausal women. J Sports Sci Med. 2010;9(2):245–52.PubMedCentralPubMed Tartibian B, Maleki BH, Abbasi A. The calciotropic hormone response to omega-3 supple-mentation during long-term weight-bearing exercise training in postmenopausal women. J Sports Sci Med. 2010;9(2):245–52.PubMedCentralPubMed
60.
go back to reference Rodacki CL, Rodacki AL, Pereira G, et al. Fish-oil supplementation enhances the effects of strength training in elderly women. Am J Clin Nutr. 2012;95(2):428–36.PubMedCrossRef Rodacki CL, Rodacki AL, Pereira G, et al. Fish-oil supplementation enhances the effects of strength training in elderly women. Am J Clin Nutr. 2012;95(2):428–36.PubMedCrossRef
Metadata
Title
Evidence for an Interaction Between Exercise and Nutrition for Improving Bone and Muscle Health
Authors
Robin M. Daly
Rachel L. Duckham
Jenny Gianoudis
Publication date
01-06-2014
Publisher
Springer US
Published in
Current Osteoporosis Reports / Issue 2/2014
Print ISSN: 1544-1873
Electronic ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-014-0207-2

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