Skip to main content
Top
Published in: BMC Primary Care 1/2004

Open Access 01-12-2004 | Research article

Evidence-based cardiovascular care in the community: A population-based cross-sectional study

Authors: Wayne Putnam, Frederick I Burge, Beverley Lawson, Jafna L Cox, Ingrid Sketris, Gordon Flowerdew, David Zitner

Published in: BMC Primary Care | Issue 1/2004

Login to get access

Abstract

Background

Ischaemic heart disease and congestive heart failure are common and important conditions in family practice. Effective treatments may be underutilized, particularly in women and the elderly. The objective of the study was to determine the rate of prescribing of evidence-based cardiovascular medications and determine if these differed by patient age or sex.

Methods

We conducted a two-year cross-sectional study involving all hospitals in the province of Nova Scotia, Canada. Subjects were all patients admitted with ischaemic heart disease with or without congestive heart failure between 15 October 1997 and 14 October 1999. The main measure was the previous outpatient use of recommended medications. Chi-square analyses followed by multivariate logistic regression analyses were used to examine age-sex differences.

Results

Usage of recommended medications varied from approximately 60% for beta-blockers and angiotensin converting enzyme (ACE) inhibitors to 90% for antihypertensive agents. Patients aged 75 and over were significantly less likely than younger patients to be taking any of the medication classes. Following adjustment for age, there were no significant differences in medication use by sex except among women aged 75 and older who were more likely to be taking beta-blockers than men in the same age group.

Conclusions

The use of evidence-based cardiovascular medications is rising and perhaps approaching reasonable levels for some drug classes. Family physicians should ensure that all eligible patients (prior myocardial infarction, congestive failure) are offered beta-blockers or ACE inhibitors.
Appendix
Available only for authorised users
Literature
1.
go back to reference Canadian Cardiovascular Society: 1997 Consensus Conference on the Evaluation and Management of Chronic Ischemic Heart Disease. Can J Cardiol. 1998, 14 Suppl: 1C-23C. Canadian Cardiovascular Society: 1997 Consensus Conference on the Evaluation and Management of Chronic Ischemic Heart Disease. Can J Cardiol. 1998, 14 Suppl: 1C-23C.
2.
go back to reference Rochon PA, Anderson GM, Tu JV, Clark JP, Gurwitz JH, Szalai JP, Lau P: Use of beta-blocker therapy in older patients after acute myocardial infarction in Ontario. CMAJ. 1999, 161: 1403-1408.PubMedPubMedCentral Rochon PA, Anderson GM, Tu JV, Clark JP, Gurwitz JH, Szalai JP, Lau P: Use of beta-blocker therapy in older patients after acute myocardial infarction in Ontario. CMAJ. 1999, 161: 1403-1408.PubMedPubMedCentral
3.
go back to reference Rochon PA, Anderson GM, Tu JV, Gurwitz JH, Clark JP, Shear NH, Lau P: Age- and gender-related use of low-dose drug therapy: The need to manufacture low-dose therapy and evaluate the minimum effective dose. J Am Geriatr Soc. 1999, 47: 954-959.CrossRefPubMed Rochon PA, Anderson GM, Tu JV, Gurwitz JH, Clark JP, Shear NH, Lau P: Age- and gender-related use of low-dose drug therapy: The need to manufacture low-dose therapy and evaluate the minimum effective dose. J Am Geriatr Soc. 1999, 47: 954-959.CrossRefPubMed
4.
go back to reference Rojas-Fernandez CH, Kephart GC, Sketris IS, Kass K: Underuse of acetylsalicylic acid in individuals with myocardial infarction, ischemic heart disease or stroke: data from the 1995 population-based Nova Scotia Health Survey. Can J Cardiol. 1999, 15: 291-296.PubMed Rojas-Fernandez CH, Kephart GC, Sketris IS, Kass K: Underuse of acetylsalicylic acid in individuals with myocardial infarction, ischemic heart disease or stroke: data from the 1995 population-based Nova Scotia Health Survey. Can J Cardiol. 1999, 15: 291-296.PubMed
5.
go back to reference Khan N, Chockalingam A, Campbell NRC: Lack of control of high blood pressure and treatment recommendations in Canada. Can J Cardiol. 2002, 18: 657-661.PubMed Khan N, Chockalingam A, Campbell NRC: Lack of control of high blood pressure and treatment recommendations in Canada. Can J Cardiol. 2002, 18: 657-661.PubMed
6.
go back to reference Cox JL: Optimizing disease management at a health care system level: The improving Cardiovascular Outcomes in Nova Scotia (ICONS) Study. Can J Cardiol. 1999, 15: 787-796.PubMed Cox JL: Optimizing disease management at a health care system level: The improving Cardiovascular Outcomes in Nova Scotia (ICONS) Study. Can J Cardiol. 1999, 15: 787-796.PubMed
7.
go back to reference Methodology World Health Organization Collaborating Centre for Drug Statistics: ATC Index with DDDs. 2001, Oslo, Norway, World Health Organization Methodology World Health Organization Collaborating Centre for Drug Statistics: ATC Index with DDDs. 2001, Oslo, Norway, World Health Organization
8.
go back to reference Cohn JN, Tognoni G: A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure. N Engl J Med. 2001, 345: 1667-1675. 10.1056/NEJMoa010713.CrossRefPubMed Cohn JN, Tognoni G: A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure. N Engl J Med. 2001, 345: 1667-1675. 10.1056/NEJMoa010713.CrossRefPubMed
9.
go back to reference Anand SS, Yusuf S: Oral anticoagulant therapy in patients with coronary artery disease: A meta-analysis. JAMA. 1999, 282: 2058-2067. 10.1001/jama.282.21.2058.CrossRefPubMed Anand SS, Yusuf S: Oral anticoagulant therapy in patients with coronary artery disease: A meta-analysis. JAMA. 1999, 282: 2058-2067. 10.1001/jama.282.21.2058.CrossRefPubMed
10.
go back to reference Inc. SAS Institute: SAS/STAT Version 8.2. 1999, Cary (NC), SAS Institute Inc Inc. SAS Institute: SAS/STAT Version 8.2. 1999, Cary (NC), SAS Institute Inc
11.
go back to reference Ko DT, Lee DS, Newman AM, Austin PC, Wang JT, Donovan LR, Tu JV: Improving trends in the use of evidence-based therapies in patients with acute myocardial infarction. Can J Cardiol. 2003, 19: 159A- Ko DT, Lee DS, Newman AM, Austin PC, Wang JT, Donovan LR, Tu JV: Improving trends in the use of evidence-based therapies in patients with acute myocardial infarction. Can J Cardiol. 2003, 19: 159A-
12.
go back to reference Pilote L, Beck CA, Karp I, Alter D, Austin P, Cox J, Humphries K, Jackevicius C, Richard H, Tu JV: Secondary prevention after acute myocardial infarction in four Canadian provinces, 1997-2000. Can J Cardiol. 2004, 20: 61-67.PubMed Pilote L, Beck CA, Karp I, Alter D, Austin P, Cox J, Humphries K, Jackevicius C, Richard H, Tu JV: Secondary prevention after acute myocardial infarction in four Canadian provinces, 1997-2000. Can J Cardiol. 2004, 20: 61-67.PubMed
13.
go back to reference Tu K, Mamdani MM, Jacka RM, Forde NJ, Rothwell DM, Tu JV: The striking effect of the Heart Outcomes Prevention Evaluation (HOPE) on ramipril prescribing in Ontario. CMAJ. 2003, 168: 553-557.PubMedPubMedCentral Tu K, Mamdani MM, Jacka RM, Forde NJ, Rothwell DM, Tu JV: The striking effect of the Heart Outcomes Prevention Evaluation (HOPE) on ramipril prescribing in Ontario. CMAJ. 2003, 168: 553-557.PubMedPubMedCentral
14.
go back to reference Klungel OH, Heckbert SR, de Boer A, Leufkens HGM, Sullivan SD, Fishman PA, Veenstra DL, Psaty BM: Lipid-lowering drug use and cardiovascular events after myocardial infarction. Ann Pharmacother. 2002, 36: 751-757. 10.1345/aph.1A308.CrossRefPubMed Klungel OH, Heckbert SR, de Boer A, Leufkens HGM, Sullivan SD, Fishman PA, Veenstra DL, Psaty BM: Lipid-lowering drug use and cardiovascular events after myocardial infarction. Ann Pharmacother. 2002, 36: 751-757. 10.1345/aph.1A308.CrossRefPubMed
15.
go back to reference Yarzebski J, Spencer F, Goldberg RJ, Lessard D, Gore JM: Temporal trends (1986-1997) in cholesterol level assessment and management practices in patients with acute myocardial infarction: A population-based perspective. Arch Intern Med. 2001, 161: 1521-1528. 10.1001/archinte.161.12.1521.CrossRefPubMed Yarzebski J, Spencer F, Goldberg RJ, Lessard D, Gore JM: Temporal trends (1986-1997) in cholesterol level assessment and management practices in patients with acute myocardial infarction: A population-based perspective. Arch Intern Med. 2001, 161: 1521-1528. 10.1001/archinte.161.12.1521.CrossRefPubMed
16.
17.
go back to reference Jackevicius CA, Anderson GM, Leiter L, Tu JV: Use of the statins in patients after acute myocardial infarction: Does evidence change practice?. Arch Intern Med. 2001, 161: 183-188. 10.1001/archinte.161.2.183.CrossRefPubMed Jackevicius CA, Anderson GM, Leiter L, Tu JV: Use of the statins in patients after acute myocardial infarction: Does evidence change practice?. Arch Intern Med. 2001, 161: 183-188. 10.1001/archinte.161.2.183.CrossRefPubMed
18.
go back to reference Julius S, Kjeldsen SE, Brunner H, Hansson L, Platt F, Ekman S, Laragh JH, McInnes G, Schork AM, Smith B, Weber M, Zanchetti A: VALUE Trial: Long-term blood pressure trends in 13,449 patients with hypertension and high cardiovascular risk. Am J Hypertens. 2003, 16: 544-548. 10.1016/S0895-7061(03)00904-X.CrossRefPubMed Julius S, Kjeldsen SE, Brunner H, Hansson L, Platt F, Ekman S, Laragh JH, McInnes G, Schork AM, Smith B, Weber M, Zanchetti A: VALUE Trial: Long-term blood pressure trends in 13,449 patients with hypertension and high cardiovascular risk. Am J Hypertens. 2003, 16: 544-548. 10.1016/S0895-7061(03)00904-X.CrossRefPubMed
19.
go back to reference Gasse C, Hense HW, Stieber J, Doring A, Liese AD, Heller G, Keil U: Factors associated with differences in antihypertensive drug treatment: results from the MONICA Augsburg Population Surveys 1989/90 and 1994/95. Soz Praventivmed. 2002, 47: 128-142.CrossRefPubMed Gasse C, Hense HW, Stieber J, Doring A, Liese AD, Heller G, Keil U: Factors associated with differences in antihypertensive drug treatment: results from the MONICA Augsburg Population Surveys 1989/90 and 1994/95. Soz Praventivmed. 2002, 47: 128-142.CrossRefPubMed
20.
go back to reference Steyn K, Gaziano TA, Bradshaw D, Laubscher R, Fourie J: Hypertension in South African adults: Results from the Demographic and Health Survey, 1998. J Hypertens. 2001, 19: 1717-1725. 10.1097/00004872-200110000-00004.CrossRefPubMed Steyn K, Gaziano TA, Bradshaw D, Laubscher R, Fourie J: Hypertension in South African adults: Results from the Demographic and Health Survey, 1998. J Hypertens. 2001, 19: 1717-1725. 10.1097/00004872-200110000-00004.CrossRefPubMed
21.
go back to reference Sudano JJ, Baker DW: Antihypertensive medication use in hispanic adults: A comparison with black adults and white adults. Med Care. 2001, 39: 575-587. 10.1097/00005650-200106000-00006.CrossRefPubMed Sudano JJ, Baker DW: Antihypertensive medication use in hispanic adults: A comparison with black adults and white adults. Med Care. 2001, 39: 575-587. 10.1097/00005650-200106000-00006.CrossRefPubMed
22.
go back to reference Fagard RH, Van den Enden M, Leeman M, Warling X: Survey on treatment of hypertension and implementation of World Health Organization/International Society of Hypertension risk stratification in primary care in Belgium. J Hypertens. 2002, 20: 1297-1302. 10.1097/00004872-200207000-00015.CrossRefPubMed Fagard RH, Van den Enden M, Leeman M, Warling X: Survey on treatment of hypertension and implementation of World Health Organization/International Society of Hypertension risk stratification in primary care in Belgium. J Hypertens. 2002, 20: 1297-1302. 10.1097/00004872-200207000-00015.CrossRefPubMed
23.
go back to reference Krumholz HM, Radford MJ, Want Y, Chen J, Heiat A, Marciniak TA: National use and effectiveness of b-blockers for the treatment of elderly patients after acute myocardial infarction: National Cooperative Cardiovascular Project. JAMA. 1998, 280: 623-629. 10.1001/jama.280.7.623.CrossRefPubMed Krumholz HM, Radford MJ, Want Y, Chen J, Heiat A, Marciniak TA: National use and effectiveness of b-blockers for the treatment of elderly patients after acute myocardial infarction: National Cooperative Cardiovascular Project. JAMA. 1998, 280: 623-629. 10.1001/jama.280.7.623.CrossRefPubMed
24.
go back to reference Fuat A, Hungin APS, Murphy JJ: Barriers to accurate diagnosis and effective management of heart failure in primary care: qualitative study. BMJ. 2003, 326: 196-10.1136/bmj.326.7382.196.CrossRefPubMedPubMedCentral Fuat A, Hungin APS, Murphy JJ: Barriers to accurate diagnosis and effective management of heart failure in primary care: qualitative study. BMJ. 2003, 326: 196-10.1136/bmj.326.7382.196.CrossRefPubMedPubMedCentral
25.
go back to reference Putnam W, Twohig PL, Burge FI, Jackson LA, Cox JL: A qualitative study of evidence in primary care: what the practitioners are saying. CMAJ. 2002, 166: 1525-1530.PubMedPubMedCentral Putnam W, Twohig PL, Burge FI, Jackson LA, Cox JL: A qualitative study of evidence in primary care: what the practitioners are saying. CMAJ. 2002, 166: 1525-1530.PubMedPubMedCentral
26.
go back to reference Allen CA, Muhlestein JB, Horne BD, Carlquist JF, Bair TL, Pearson RR, Li Q, Anderson JL: Statin therapy is associated with reduced mortality across all age groups of individuals with significant coronary disease, including very elderly patients. J Am Coll Cardiol. 2002, 40: 1777-1785. 10.1016/S0735-1097(02)02477-4.CrossRef Allen CA, Muhlestein JB, Horne BD, Carlquist JF, Bair TL, Pearson RR, Li Q, Anderson JL: Statin therapy is associated with reduced mortality across all age groups of individuals with significant coronary disease, including very elderly patients. J Am Coll Cardiol. 2002, 40: 1777-1785. 10.1016/S0735-1097(02)02477-4.CrossRef
27.
go back to reference McLaughlin TJ, Soumerai SB, Willison DJ, Gurwitz JH, Borbas C, Guadagnoli E, McLaughlin B, Morris N, Cheng SC, Hauptman PJ, Antman E, Casey L, Asinger R, Fredarick G: Adherence to national guidelines for drug treatment of suspected acute myocardial infarction: Evidence for undertreatment in women and the elderly. Arch Intern Med. 1996, 156: 799-805. 10.1001/archinte.156.7.799.CrossRefPubMed McLaughlin TJ, Soumerai SB, Willison DJ, Gurwitz JH, Borbas C, Guadagnoli E, McLaughlin B, Morris N, Cheng SC, Hauptman PJ, Antman E, Casey L, Asinger R, Fredarick G: Adherence to national guidelines for drug treatment of suspected acute myocardial infarction: Evidence for undertreatment in women and the elderly. Arch Intern Med. 1996, 156: 799-805. 10.1001/archinte.156.7.799.CrossRefPubMed
28.
go back to reference Ganz DA, Lamas GA, Orav EJ, Goldman L, Gutierrez PR, Mangione CM: Age-related differences in management of heart disease: a study of cardiac medication use in an older cohort. Pacemaker Selection in the Elderly (PASE) Investigators. J Am Geriatr Soc. 1999, 47: 145-150.CrossRefPubMed Ganz DA, Lamas GA, Orav EJ, Goldman L, Gutierrez PR, Mangione CM: Age-related differences in management of heart disease: a study of cardiac medication use in an older cohort. Pacemaker Selection in the Elderly (PASE) Investigators. J Am Geriatr Soc. 1999, 47: 145-150.CrossRefPubMed
29.
go back to reference Mantel-Teeuwisse AK, Verschuren WM, Klungel OH, Kromhout D, Lindemans AD, Avorn J, Porsius AJ, de Boer A: Undertreatment of hypercholesterolaemia: a population-based study. BRJ Clin Pharmacol. 2003, 55: 389-397.CrossRef Mantel-Teeuwisse AK, Verschuren WM, Klungel OH, Kromhout D, Lindemans AD, Avorn J, Porsius AJ, de Boer A: Undertreatment of hypercholesterolaemia: a population-based study. BRJ Clin Pharmacol. 2003, 55: 389-397.CrossRef
30.
go back to reference Pears E, Hannaford PC, Taylor MW: Gender, age and deprivation differences in the primary care management of hypertension in Scotland: A cross-sectional database study. Fam Pract. 2003, 20: 22-31. 10.1093/fampra/20.1.22.CrossRefPubMed Pears E, Hannaford PC, Taylor MW: Gender, age and deprivation differences in the primary care management of hypertension in Scotland: A cross-sectional database study. Fam Pract. 2003, 20: 22-31. 10.1093/fampra/20.1.22.CrossRefPubMed
31.
go back to reference Dombrook-Lavender KA, Roth MT, Pieper JA: Secondary prevention of coronary heart disease in the elderly. Ann Pharmacother. 2003, 37: 1867-1876. 10.1345/aph.1D026.CrossRef Dombrook-Lavender KA, Roth MT, Pieper JA: Secondary prevention of coronary heart disease in the elderly. Ann Pharmacother. 2003, 37: 1867-1876. 10.1345/aph.1D026.CrossRef
32.
go back to reference Ayanian JZ, Landrum MB, McNeil BJ: Use of cholesterol-lowering therapy by elderly adults after myocardial infarction. Arch Intern Med. 2002, 162: 1013-1019. 10.1001/archinte.162.9.1013.CrossRefPubMed Ayanian JZ, Landrum MB, McNeil BJ: Use of cholesterol-lowering therapy by elderly adults after myocardial infarction. Arch Intern Med. 2002, 162: 1013-1019. 10.1001/archinte.162.9.1013.CrossRefPubMed
33.
go back to reference Jackevicius CA, Mamdani M, Tu JV: Adherence with statin therapy in elderly patients with and without acute coronary syndromes. JAMA. 2002, 288: 462-467. 10.1001/jama.288.4.462.CrossRefPubMed Jackevicius CA, Mamdani M, Tu JV: Adherence with statin therapy in elderly patients with and without acute coronary syndromes. JAMA. 2002, 288: 462-467. 10.1001/jama.288.4.462.CrossRefPubMed
34.
go back to reference Di Cecco R, Patel U, Upshur RE: Is there a clinically significant gender bias in post-myocardial infarction pharmacological management in the older (>60) population of a primary care practice?. BMC Fam Pract. 2002, 3: 8-10.1186/1471-2296-3-8.CrossRefPubMedPubMedCentral Di Cecco R, Patel U, Upshur RE: Is there a clinically significant gender bias in post-myocardial infarction pharmacological management in the older (>60) population of a primary care practice?. BMC Fam Pract. 2002, 3: 8-10.1186/1471-2296-3-8.CrossRefPubMedPubMedCentral
35.
go back to reference Weiss R, Buckley K, Clifford T: Changing patterns of initial drug therapy for the treatment of hypertension in a Medicaid population, 1997-2000. Clin Ther. 2002, 24: 1451-1462. 10.1016/S0149-2918(02)80048-0.CrossRefPubMed Weiss R, Buckley K, Clifford T: Changing patterns of initial drug therapy for the treatment of hypertension in a Medicaid population, 1997-2000. Clin Ther. 2002, 24: 1451-1462. 10.1016/S0149-2918(02)80048-0.CrossRefPubMed
36.
go back to reference Cox JL, Zitner D, Courtney KD, MacDonald DL, Paterson G, Cochrane B, Mathers J, Henry H, Flowerdew G, Johnstone DE: Undocumented patient information: An impediment to quality of care. Am J Med. 2003, 114: 211-216. 10.1016/S0002-9343(02)01481-X.CrossRefPubMed Cox JL, Zitner D, Courtney KD, MacDonald DL, Paterson G, Cochrane B, Mathers J, Henry H, Flowerdew G, Johnstone DE: Undocumented patient information: An impediment to quality of care. Am J Med. 2003, 114: 211-216. 10.1016/S0002-9343(02)01481-X.CrossRefPubMed
37.
go back to reference Heart Outcomes Prevention Evaluation Study Investigators: Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. N Engl J Med. 2000, 342: 145-153. 10.1056/NEJM200001203420301.CrossRef Heart Outcomes Prevention Evaluation Study Investigators: Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. N Engl J Med. 2000, 342: 145-153. 10.1056/NEJM200001203420301.CrossRef
Metadata
Title
Evidence-based cardiovascular care in the community: A population-based cross-sectional study
Authors
Wayne Putnam
Frederick I Burge
Beverley Lawson
Jafna L Cox
Ingrid Sketris
Gordon Flowerdew
David Zitner
Publication date
01-12-2004
Publisher
BioMed Central
Published in
BMC Primary Care / Issue 1/2004
Electronic ISSN: 2731-4553
DOI
https://doi.org/10.1186/1471-2296-5-6

Other articles of this Issue 1/2004

BMC Primary Care 1/2004 Go to the issue