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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 1/2014

01-01-2014 | Hepatobiliary Tumors

Evaluation of the Usefulness of the Indocyanine Green Clearance Test for Chemotherapy-Associated Liver Injury in Patients with Colorectal Cancer Liver Metastasis

Authors: Taiichi Wakiya, MD, PhD, Daisuke Kudo, MD, PhD, Yoshikazu Toyoki, MD, PhD, Keinosuke Ishido, MD, PhD, Norihisa Kimura, MD, PhD, Shunji Narumi, MD, PhD, Hiroshi Kijima, MD, PhD, Kenichi Hakamada, MD, PhD

Published in: Annals of Surgical Oncology | Issue 1/2014

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Abstract

Background

The indocyanine green (ICG) clearance test is reported to be useful for the preoperative evaluation of hepatic functional reserve. However, the ICG clearance test has not been sufficiently investigated in patients with colorectal liver metastasis after chemotherapy. The aim of the present study was to evaluate whether the ICG clearance test is a useful parameter for the preoperative detection of chemotherapy-associated liver injury.

Methods

Ninety-four patients undergoing liver resection for colorectal liver metastasis after chemotherapy were studied. The medical records for each case were retrospectively reviewed. They underwent pathological assessment to clarify the degree of histopathological liver injury of the nontumoral liver parenchyma. In addition, the correlation between the pathological score and the ICG retention rate at 15 min (ICG-R15) was analyzed.

Results

Sinusoidal injury was observed in the 31 of 94 patients. Steatohepatitis was observed in the 40 of 94 patients. There was no strong correlation between the preoperative ICG-R15 value and the sinusoidal pathological score (r = 0.117, P = 0.261). There was no strong correlation between the ICG-R15 and the nonalcoholic fatty liver disease activity score (r = 0.215, P = 0.037).

Conclusions

It was difficult to predict the degree of chemotherapy-associated liver injury by the preoperative ICG-R15 value. It is necessary to estimate the hepatic functional reserve based on a combination of several clinical indicators without relying on the ICG test, in order to perform a safe radical liver resection.
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Metadata
Title
Evaluation of the Usefulness of the Indocyanine Green Clearance Test for Chemotherapy-Associated Liver Injury in Patients with Colorectal Cancer Liver Metastasis
Authors
Taiichi Wakiya, MD, PhD
Daisuke Kudo, MD, PhD
Yoshikazu Toyoki, MD, PhD
Keinosuke Ishido, MD, PhD
Norihisa Kimura, MD, PhD
Shunji Narumi, MD, PhD
Hiroshi Kijima, MD, PhD
Kenichi Hakamada, MD, PhD
Publication date
01-01-2014
Publisher
Springer US
Published in
Annals of Surgical Oncology / Issue 1/2014
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-013-3203-3

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