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International Journal of Hematology
Published in: International Journal of Hematology 5/2017

01-05-2017 | Original Article

Evaluation of the safety and efficacy of recombinant soluble thrombomodulin for patients with disseminated intravascular coagulation associated with acute leukemia: multicenter prospective study by the Tohoku Hematology Forum

Authors: Hisayuki Yokoyama, Naoto Takahashi, Yuna Katsuoka, Mitsue Inomata, Toshihiro Ito, Kuniaki Meguro, Yoshihiro Kameoka, Riko Tsumanuma, Kazunori Murai, Hideyoshi Noji, Kenichi Ishizawa, Shigeki Ito, Yasushi Onishi, Hideo Harigae, On behalf of the Tohoku Hematology Forum

Published in: International Journal of Hematology | Issue 5/2017

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Abstract

It has been suggested that use of recombinant soluble thrombomodulin (rTM) is superior to conventional drugs in treatment of disseminated intravascular coagulation (DIC) complicating acute leukemia. However, its safety and efficacy have not been fully examined in prospective studies. Here, we performed a multicenter prospective study to examine outcomes of rTM treatment for DIC in patients with acute leukemia. Of 33 patients registered in this study, 13 had acute myeloid leukemia (AML), three had acute lymphoblastic leukemia (ALL), and 17 had acute promyelocytic leukemia (APL). The cumulative rates of DIC resolution at day 7 and day 35 were 56 and 81% in AML/ALL and 53 and 77% in APL, respectively. The median time from the initiation of rTM to DIC resolution was 4 days in AML/ALL and 6 days in APL patients. Adverse events related to hemorrhage occurred in two AML/ALL patients (13%) and three APL patients (18%). Of these, one AML/ALL patient died with intracranial hemorrhage, and two APL patients died with intracranial hemorrhage and pulmonary hemorrhage. These results suggest that rTM may improve the survival of acute leukemia patients with DIC by inhibiting early death related to hemorrhagic events, as reported previously.
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Metadata
Title
Evaluation of the safety and efficacy of recombinant soluble thrombomodulin for patients with disseminated intravascular coagulation associated with acute leukemia: multicenter prospective study by the Tohoku Hematology Forum
Authors
Hisayuki Yokoyama
Naoto Takahashi
Yuna Katsuoka
Mitsue Inomata
Toshihiro Ito
Kuniaki Meguro
Yoshihiro Kameoka
Riko Tsumanuma
Kazunori Murai
Hideyoshi Noji
Kenichi Ishizawa
Shigeki Ito
Yasushi Onishi
Hideo Harigae
On behalf of the Tohoku Hematology Forum
Publication date
01-05-2017
Publisher
Springer Japan
Published in
International Journal of Hematology / Issue 5/2017
Print ISSN: 0925-5710
Electronic ISSN: 1865-3774
DOI
https://doi.org/10.1007/s12185-017-2190-8

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