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EJNMMI Research
Published in: EJNMMI Research 1/2013

Open Access 01-12-2013 | Original research

Evaluation of the biodistribution and radiation dosimetry of the 18F-labelled amyloid imaging probe [18F]FACT in humans

Authors: Miho Shidahara, Manabu Tashiro, Nobuyuki Okamura, Shozo Furumoto, Katsutoshi Furukawa, Shoichi Watanuki, Kotaro Hiraoka, Masayasu Miyake, Ren Iwata, Hajime Tamura, Hiroyuki Arai, Yukitsuka Kudo, Kazuhiko Yanai

Published in: EJNMMI Research | Issue 1/2013

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Abstract

Background

The biodistribution and radiation dosimetry of the 18F-labelled amyloid imaging probe ([18F] FACT) was investigated in humans.

Methods

Six healthy subjects (three males and three females) were enrolled in this study. An average of 160.8 MBq of [18F] FACT was intravenously administered, and then a series of whole-body PET scans were performed. Nineteen male and 20 female source organs, and the remainder of the body, were studied to estimate time-integrated activity coefficients. The mean absorbed dose in each target organ and the effective dose were estimated from the time-integrated activity coefficients in the source organs. Biodistribution data from [18F] FACT in mice were also used to estimate absorbed doses and the effective dose in human subjects; this was compared with doses of [18F] FACT estimated from human PET data.

Results

The highest mean absorbed doses estimated using human PET data were observed in the gallbladder (333 ± 251 μGy/MBq), liver (77.5 ± 14.5 μGy/MBq), small intestine (33.6 ± 30.7 μGy/MBq), upper large intestine (29.8 ± 15.0 μGy/MBq) and lower large intestine (25.2 ± 12.6 μGy/MBq). The average effective dose estimated from human PET data was 18.6 ± 3.74 μSv/MBq. The highest mean absorbed dose value estimated from the mouse data was observed in the small intestine (38.5 μGy/MBq), liver (25.5 μGy/MBq) and urinary bladder wall (43.1 μGy/MBq). The effective dose estimated from the mouse data was 14.8 μSv/MBq for [18F] FACT.

Conclusions

The estimated effective dose from the human PET data indicated that the [18F] FACT PET study was acceptable for clinical purposes.
Appendix
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Metadata
Title
Evaluation of the biodistribution and radiation dosimetry of the 18F-labelled amyloid imaging probe [18F]FACT in humans
Authors
Miho Shidahara
Manabu Tashiro
Nobuyuki Okamura
Shozo Furumoto
Katsutoshi Furukawa
Shoichi Watanuki
Kotaro Hiraoka
Masayasu Miyake
Ren Iwata
Hajime Tamura
Hiroyuki Arai
Yukitsuka Kudo
Kazuhiko Yanai
Publication date
01-12-2013
Publisher
Springer Berlin Heidelberg
Published in
EJNMMI Research / Issue 1/2013
Electronic ISSN: 2191-219X
DOI
https://doi.org/10.1186/2191-219X-3-32

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