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01-01-2007 | Original Paper

Evaluation of the antimalarial and antileishmanial activity of plants from the Greek island of Crete

Authors: N. Fokialakis, E. Kalpoutzakis, B. L. Tekwani, S. I. Khan, M. Kobaisy, A. L. Skaltsounis, S. O. Duke

Published in: Journal of Natural Medicines | Issue 1/2007

Abstract

Different parts of 65 plant species from the Greek island of Crete have been extracted and the 249 extracts obtained have been investigated for in-vitro antiprotozoal activity. Their activity against chloroquine-sensitive (D6) and resistant (W2) strains of Plasmodium falciparum and Leishmania donovani promastigotes was determined. Their cytotoxicity on a mammalian kidney fibroblast (Vero) cell line was also tested. Dichloromethane and methanol extracts of Berberis cretica and methanol extracts of Cytinus hypocistis subsp. hypocistis, C. hypocistis subsp. orientalis, and C. ruber had significant activity against both strains of P. falciparum (IC₅₀<10 μg mL⁻¹). Dichloromethane extracts of Eryngium ternatum, Origanum dictamnus, and Origanum microphyllum, and the methanolic extract of Eryngium amorginum had significant activity against Leishmania donovani (IC₅₀<10 μg mL⁻¹). None of the extracts was cytotoxic.

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Title: Evaluation of the antimalarial and antileishmanial activity of plants from the Greek island of Crete
Authors: N. Fokialakis
E. Kalpoutzakis
B. L. Tekwani
S. I. Khan
M. Kobaisy
A. L. Skaltsounis
S. O. Duke
Publication date: 01-01-2007
Publisher: Springer-Verlag
Published in: Journal of Natural Medicines / Issue 1/2007
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-006-0013-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Evaluation of the antimalarial and antileishmanial activity of plants from the Greek island of Crete

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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