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Nuclear Medicine and Molecular Imaging
Published in: Nuclear Medicine and Molecular Imaging 3/2015

01-09-2015 | Original Article

Evaluation of Selective Arterial Embolization Effect by Chitosan Micro-Hydrogels in Hindlimb Sarcoma Rodent Models Using Various Imaging Modalities

Authors: Tai Kyoung Lee, JeongIl Kwon, Kyung Sook Na, Hwan-Seok Jeong, Hyosook Hwang, Phil-Sun Oh, Dong Hyun Kim, Kyu Yun Jang, Seok Tae Lim, Myung-Hee Sohn, Hwan-Jeong Jeong

Published in: Nuclear Medicine and Molecular Imaging | Issue 3/2015

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Abstract

Purpose

Embolization is mainly used to reduce the size of locally advanced tumors. In this study, selective arterial catheterization with chitosan micro-hydrogels (CMH) into the femoral artery was performed and the therapeutic effect was validated using different imaging methods.

Methods

Male SD rats (n = 18, 6 weeks old) were randomly assigned into three groups: Group 1 as control, Group 2 without any ligation of distal femoral artery, and Group 3 with temporary ligation of the distal femoral artery. RR1022 sarcoma cell lines were inoculated into thigh muscle. After 1 week, CMH was injected into the proximal femoral artery. Different imaging modalities were performed during a 3-week follow-up.

Results

The tumor size was significantly (P < 0.001) decreased in both Group 2 and Group 3 (P < 0.001) after selective arterial embolization therapy. 18F-FDG-PET/CT revealed decreased intensity of 18F-FDG uptake in tumors. The accumulation status of 125I-CMH near the tumor was verified by gamma camera.

Conclusions

Appropriate selective arterial embolization therapy with CMH was.
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Metadata
Title
Evaluation of Selective Arterial Embolization Effect by Chitosan Micro-Hydrogels in Hindlimb Sarcoma Rodent Models Using Various Imaging Modalities
Authors
Tai Kyoung Lee
JeongIl Kwon
Kyung Sook Na
Hwan-Seok Jeong
Hyosook Hwang
Phil-Sun Oh
Dong Hyun Kim
Kyu Yun Jang
Seok Tae Lim
Myung-Hee Sohn
Hwan-Jeong Jeong
Publication date
01-09-2015
Publisher
Springer Berlin Heidelberg
Published in
Nuclear Medicine and Molecular Imaging / Issue 3/2015
Print ISSN: 1869-3474
Electronic ISSN: 1869-3482
DOI
https://doi.org/10.1007/s13139-014-0316-y

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