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European Journal of Nuclear Medicine and Molecular Imaging

Published in:

01-11-2014 | Editorial

Evaluation of response to immunotherapy: new challenges and opportunities for PET imaging

Authors: Laura Gilardi, Chiara Maria Grana, Giovanni Paganelli

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 11/2014

Excerpt

Cancer immunotherapy focuses on the development of agents that can activate the immune system to recognize and kill tumour cells. It encompasses different strategies, the first of which is the activation of innate and adaptive immune effector mechanisms, such as vaccination with tumour antigens, treatment with cytokines (for example, interleukin 2 or interferon α) and enhancement of antigen presentation. Another important strategy involves neutralizing the inhibitory and suppressive mechanisms and includes the use of antibodies to deplete the regulatory T cells and the use of antibodies against immune-checkpoint molecules, for example cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and programmed cell death (PD1) [1]. …

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Title: Evaluation of response to immunotherapy: new challenges and opportunities for PET imaging
Authors: Laura Gilardi
Chiara Maria Grana
Giovanni Paganelli
Publication date: 01-11-2014
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 11/2014
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-014-2848-x

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Evaluation of response to immunotherapy: new challenges and opportunities for PET imaging

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